scholarly journals Low-dose BMP-2 and MSC dual delivery onto coral scaffold for critical-size bone defect regeneration in sheep

2017 ◽  
Vol 35 (12) ◽  
pp. 2637-2645 ◽  
Author(s):  
Adeline Decambron ◽  
Alexandre Fournet ◽  
Morad Bensidhoum ◽  
Mathieu Manassero ◽  
Frédéric Sailhan ◽  
...  
Keyword(s):  
Bone Defect ◽  
Low Dose ◽  
Critical Size ◽  
Coral Scaffold

scholarly journals Leucocyte- and Platelet-Rich Fibrin Block: Its Use for the Treatment of a Large Cyst with Implant-Based Rehabilitation

Medicina ◽  
2021 ◽  
Vol 57 (2) ◽  
pp. 180 ◽  
Author(s):  
Rodolfo Mauceri ◽  
Denise Murgia ◽  
Orazio Cicero ◽  
Luigi Paternò ◽  
Luca Fiorillo ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Defect ◽  
Bone Healing ◽  
Bone Substitute ◽  
Alveolar Bone ◽  
Critical Size ◽  
Large Bone ◽  
Alveolar Bone Defect ◽  
Positive Results ◽  
Autologous Platelet

The management of critical-size bone defects is still demanding. Recently, autologous platelet concentrates in combination with bone substitute have been applied and reported in a few studies. Our aim is to report the healing of a critical-size alveolar bone defect treated with a new bone regeneration technique by means of L-PRF and L-PRF blocks. A 45-year-old woman presented a large cystic lesion; the extraction of three teeth, a cyst removal procedure, and bone regeneration procedures with L-PRF and L-PRF blocks were planned. The L-PRF block was prepared by mixing a bone substitute with a piece of L-PRF membrane and liquid fibrinogen. Additionally, after bone healing an implant-based rehabilitation was optimally performed. On the basis of the positive results, in terms of bone healing and tissue regeneration in a large bone defect, the application of L-PRF and L-PRF blocks, in agreement with the scarce literature, is suggested as a feasible procedure in selected cases.

Tissue‐Engineered Bone Functionalized with MoS 2 Nanosheets for Enhanced Repair of Critical‐Size Bone Defect in Rats

2021 ◽  
pp. 2109882
Author(s):  
Jie Zhang ◽  
Boyou Zhang ◽  
Zefeng Zheng ◽  
Qingyun Cai ◽  
Jingcheng Wang ◽  
...  
Keyword(s):  
Bone Defect ◽  
Critical Size

108 A CRITICAL-SIZE CRANIOFACIAL BONE DEFECT MODEL IN THE YORKSHIRE PIG

2011 ◽  
Vol 23 (1) ◽  
pp. 159 ◽  
Author(s):  
A. J. Maki ◽  
S. G. Clark ◽  
J. R. Woodard ◽  
M. Goldwasser ◽  
M. B. Wheeler
Keyword(s):  
Bone Defect ◽  
Critical Size ◽  
Rapid Development ◽  
Bone Defects ◽  
Defect Size ◽  
Posterior Region ◽  
Primate Species ◽  
Large Animal ◽  
Mineral Density ◽  
Calcified Tissue

Substantial and innovative developments in the field of bone tissue engineering have prompted increased demand for suitable pre-clinical large animal models. The pig has several advantages over other non-primate species, including availability, rapid growth, large litters, and similar anatomy and physiology to humans. These characteristics make them ideal models for research in diverse applications such as cardiovascular disease, pharmacological activity testing, and organ transplantation. There has been an increased interest in the use of swine as a model for bone healing and grafting techniques. Maxillofacial surgeons strive to develop the best therapy for large bone defects in the face resulting from tumour resection, congenital abnormalities, and traumatic injuries. Creating a model to study a critical-sized bone defect in the mandible, which does not spontaneously heal without clinical intervention, would be a method to test growth factors and synthetic bone graft therapies. However, the size of bone defect required to create this condition has not been ascertained. In the current study, we examined the in vivo healing response for 4, 8, and 16 weeks of surgically created bone defects in the posterior region of the pig mandible. Yorkshire barrows (n = 12) 6–7 months of age were used for the study. All animal experiments conformed to the University of Illinois Institutional Animal Care and Use Committee (IACUC) guidelines. Animals were maintained under general anaesthesia and transcortical, circular defects with diameters of 6, 10, 16, or 25 mm were created on both sides of the mandible. The presence and amount of calcified tissue was assessed using radiographs and dual energy x-ray absorptiometry (DEXA). Tissue morphology was examined using hard-tissue histological methods and a light microscope. Defect diameters of 6, 10, and 16 mm had completed healing or were in the process of healing within the 16-week timeframe of the study. Compared to controls, average percent differences in bone mineral density, in order of increasing defect size, were 0.62%, 28.1%, and 54.5%, respectively. In contrast, 25 mm diameter defects displayed limited collagenous tissue ingrowth, and the presence of calcified tissue was not detected, as indicated by radiographs and histological staining. As the defect size increased, the time required to heal was prolonged until a critical size was determined and normal bone was not completely regenerated. In conclusion, circular defects in the posterior region of the pig mandible with diameters equal or greater than 25 mm will result in limited healing without additional medical intervention and can be termed critical-sized defects. This porcine model will allow for the rapid development and testing of new approaches for the repair of damaged bone, which is especially prevalent in the craniofacial area. This work was partially supported by the Carle Foundation Hospital (#2007-04072) and the Illinois Regenerative Medicine Institute (IDPH #63080017).

Wharton's Jelly for Augmented Cleft Palate Repair in a Rat Critical-Size Alveolar Bone Defect Model

2020 ◽  
Vol 26 (11-12) ◽  
pp. 591-601 ◽  
Author(s):  
Suchit Sahai ◽  
Marysuna Wilkerson ◽  
Hasen Xue ◽  
Nicolas Moreno ◽  
Louis Carrillo ◽  
...  
Keyword(s):  
Cleft Palate ◽  
Bone Defect ◽  
Alveolar Bone ◽  
Critical Size ◽  
Wharton’S Jelly ◽  
Defect Model ◽  
Wharton's Jelly ◽  
Cleft Palate Repair ◽  
Palate Repair ◽  
Alveolar Bone Defect

The Number of Injury Events Associated With the Critical Size of Bipolar Bone Defects in Rugby Players With Traumatic Anterior Shoulder Instability

2019 ◽  
Vol 47 (12) ◽  
pp. 2803-2808 ◽  
Author(s):  
Yoshinori Hasegawa ◽  
Takayuki Kawasaki ◽  
Shuko Nojiri ◽  
Shogo Sobue ◽  
Takefumi Kaketa ◽  
...  
Keyword(s):  
Bone Defect ◽  
Shoulder Instability ◽  
Critical Size ◽  
Multiple Logistic Regression Analysis ◽  
Secondary Analysis ◽  
Bone Defects ◽  
Anterior Shoulder Instability ◽  
Primary Analysis ◽  
Cutoff Value ◽  
Rugby Players

Background: The size of a glenoid bone defect is responsible for reduction in shoulder stability and is correlated with the number of instability events. Biomechanical studies have suggested that it should be considered concomitantly with the Hill-Sachs lesion as “bipolar” bone defects for assessing structural degradation, but the definitive number of instability events associated with the critical size has not been investigated. Purpose: To (1) confirm that the number of instability events is the predictor of a critical size of bipolar bone defects and (2) demonstrate the cutoff value of the number of instability events for these defects in rugby players with traumatic anterior shoulder instability. Study Design: Cross-sectional study; Level of evidence, 3. Methods: One-hundred forty-four rugby players with anterior shoulder instability underwent morphologic evaluation for glenoid and Hill-Sachs lesions by computed tomography and determination of the critical (a glenoid bone defect of ≥25% or an off-track Hill-Sachs lesion) and subcritical (a glenoid bone defect of ≥13.5%) size of bipolar bone defects. In the primary analysis, the prevalence of the critical and subcritical size of bipolar bone defects was investigated. In the secondary analysis, the authors explored the predictors for these bone defects and determined the cutoff value correlating with the critical and subcritical size of bipolar bone defects by applying receiver operating characteristic curves. Results: The primary analysis revealed that the prevalence of critical and subcritical size of bipolar bone defects was 20.8% and 61.8% of 144 shoulders, respectively. In the secondary analysis, multiple logistic regression analysis demonstrated that the total number of shoulder instability events and dominant shoulder were the significant factors associated with the critical and subcritical size of bipolar bone defects. The cutoff value for the number of instability events that correlated with critical bipolar bone defects was 6 for the dominant and 9 for the nondominant shoulder, whereas it was 4 for the dominant and 5 for the nondominant shoulder for subcritical bipolar bone defects. Conclusion: The number of shoulder instability events and the dominant shoulder were the predictors for the critical and subcritical size of bipolar bone defects for a shoulder with traumatic instability. Four injury events should herald caution when treating rugby players with shoulder instability.

Thiol-acrylate nanocomposite foams for critical size bone defect repair: A novel biomaterial

2013 ◽  
Vol 101 (12) ◽  
pp. 3531-3541 ◽  
Author(s):  
Leah Garber ◽  
Cong Chen ◽  
Kameron V. Kilchrist ◽  
Christopher Bounds ◽  
John A. Pojman ◽  
...  
Keyword(s):  
Bone Defect ◽  
Critical Size ◽  
Bone Defect Repair ◽  
Nanocomposite Foams ◽  
Defect Repair

Critical-size bone defect repair using amniotic fluid stem cell/collagen constructs: Effect of oral ferutinin treatment in rats

Life Sciences ◽  
2015 ◽  
Vol 121 ◽  
pp. 174-183 ◽  
Author(s):  
Manuela Zavatti ◽  
Laura Bertoni ◽  
Tullia Maraldi ◽  
Elisa Resca ◽  
Francesca Beretti ◽  
...  
Keyword(s):  
Stem Cell ◽  
Amniotic Fluid ◽  
Bone Defect ◽  
Critical Size ◽  
Bone Defect Repair ◽  
Defect Repair ◽  
Amniotic Fluid Stem Cell
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