Thiol-acrylate nanocomposite foams for critical size bone defect repair: A novel biomaterial

2013 ◽  
Vol 101 (12) ◽  
pp. 3531-3541 ◽  
Author(s):  
Leah Garber ◽  
Cong Chen ◽  
Kameron V. Kilchrist ◽  
Christopher Bounds ◽  
John A. Pojman ◽  
...  
Keyword(s):  
Bone Defect ◽  
Critical Size ◽  
Bone Defect Repair ◽  
Nanocomposite Foams ◽  
Defect Repair

Critical-size bone defect repair using amniotic fluid stem cell/collagen constructs: Effect of oral ferutinin treatment in rats

Life Sciences ◽  
2015 ◽  
Vol 121 ◽  
pp. 174-183 ◽  
Author(s):  
Manuela Zavatti ◽  
Laura Bertoni ◽  
Tullia Maraldi ◽  
Elisa Resca ◽  
Francesca Beretti ◽  
...  
Keyword(s):  
Stem Cell ◽  
Amniotic Fluid ◽  
Bone Defect ◽  
Critical Size ◽  
Bone Defect Repair ◽  
Defect Repair ◽  
Amniotic Fluid Stem Cell

BMP-2, PDGF-BB, and bone marrow mesenchymal cells in a macroporous β -TCP scaffold for critical-size bone defect repair in rats

2015 ◽  
Vol 10 (4) ◽  
pp. 045008 ◽  
Author(s):  
Carlos del Rosario ◽  
María Rodríguez-Évora ◽  
Ricardo Reyes ◽  
Araceli Delgado ◽  
Carmen Évora
Keyword(s):  
Bone Marrow ◽  
Bone Defect ◽  
Critical Size ◽  
Mesenchymal Cells ◽  
Bone Defect Repair ◽  
Defect Repair ◽  
Bone Marrow Mesenchymal Cells

scholarly journals In-Vivo Efficacy of Compliant 3D Nano-Composite in Critical-Size Bone Defect Repair: a Six Month Preclinical Study in Rabbit

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e77578 ◽  
Author(s):  
Nitin Sagar ◽  
Alok K. Pandey ◽  
Deepak Gurbani ◽  
Kainat Khan ◽  
Dhirendra Singh ◽  
...  
Keyword(s):  
Bone Defect ◽  
Critical Size ◽  
Preclinical Study ◽  
Nano Composite ◽  
In Vivo Efficacy ◽  
Bone Defect Repair ◽  
Defect Repair

scholarly journals Large-Pore Platelet-Rich Fibrin with a Mg Ring to Allow MC3T3-E1 Preosteoblast Migration and to Improve Osteogenic Ability for Bone Defect Repair

2021 ◽  
Vol 22 (8) ◽  
pp. 4022
Author(s):  
Pei-Chun Wong ◽  
Chen-Yun Wang ◽  
Jason Shian-Ching Jang ◽  
Chian-Her Lee ◽  
Jia-Lin Wu
Keyword(s):  
Cell Migration ◽  
Growth Factors ◽  
Bone Defect ◽  
Critical Size ◽  
Cell Attachment ◽  
Calcium Deposition ◽  
Platelet Rich Fibrin ◽  
Bone Defect Repair ◽  
Large Pore ◽  
Defect Repair

Platelet-rich fibrin (PRF) is a natural fibrin meshwork material with multiple functions that are suitable for tissue engineering applications. PRF provides a suitable scaffold for critical-size bone defect treatment due to its platelet cytokines and rich growth factors. However, the structure of PRF not only promotes cell attachment but also, due to its density, provides a pool for cell migration into the PRF to facilitate regeneration. In our study, we used repeated freeze drying to enlarge the pores of PRF to engineer large-pore PRF (LPPRF), a type of PRF that has expanded pores for cell migration. Moreover, a biodegradable Mg ring was used to provide stability to bone defects and the release of Mg ions during degradation may enhance osteoconduction and osteoinduction. Our results revealed that cell migration was more extensive when LPPRF was used rather than when PRF was used and that LPPRF retained the growth factors present in PRF. Moreover, the Mg ions released from the Mg ring during degradation significantly enhanced the calcium deposition of MC3T3-E1 preosteoblasts. In the present study, a bone substitute comprising LPPRF combined with a Mg ring was demonstrated to have much potential for critical-size bone defect repair.

scholarly journals Bone defect repair on the alveolar wall of the maxillary sinus using collagen membranes and temporal fascia: an experimental study in monkeys

2011 ◽  
Vol 77 (4) ◽  
pp. 439-446 ◽  
Author(s):  
Adalberto Novaes Silva ◽  
José Américo de Oliveira ◽  
Maria Célia Jamur ◽  
José Ari Gualberto Junqueira ◽  
Vani Maria Correa ◽  
...  
Keyword(s):  
Experimental Study ◽  
Maxillary Sinus ◽  
Bone Defect ◽  
Alveolar Wall ◽  
Bone Defect Repair ◽  
Temporal Fascia ◽  
Defect Repair ◽  
Collagen Membranes

Clay-based nanocomposite hydrogel with attractive mechanical properties and sustained bioactive ion release for bone defect repair

2021 ◽  
Author(s):  
Xinyun Zhai ◽  
Changshun Ruan ◽  
Jie Shen ◽  
Chuping Zheng ◽  
Xiaoli Zhao ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Defect ◽  
Nanocomposite Hydrogel ◽  
Ion Release ◽  
Bone Defect Repair ◽  
Defect Repair ◽  
Gradual Release

Using nanoclay as the physical crosslinker, a novel clay-based nanocomposite hydrogel with attractive mechanical properties has be obtained, and the gradual release of intrinsic Mg2+ and Si4+ endows the system with excellent osteogenesis.

Injectable gel graft for bone defect repair

2014 ◽  
Vol 9 (1) ◽  
pp. 41-51 ◽  
Author(s):  
Josephine Fang ◽  
Zhi Yang ◽  
ShihJye Tan ◽  
Charisse Tayag ◽  
Marcel E Nimni ◽  
...  
Keyword(s):  
Bone Defect ◽  
Bone Defect Repair ◽  
Defect Repair
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