scholarly journals Effect of ACL graft material on anterior knee force during simulated in vivo ovine motion applied to the porcine knee: An in vitro examination of force during 2000 cycles

2015 ◽  
Vol 33 (12) ◽  
pp. 1789-1795 ◽  
Author(s):  
Daniel V. Boguszewski ◽  
Christopher T. Wagner ◽  
David L. Butler ◽  
Jason T. Shearn
Keyword(s):  
Graft Material ◽  
Acl Graft ◽  
Anterior Knee ◽  
Porcine Knee ◽  
In Vitro Examination

Effect of ACL graft material on joint forces during a simulated in vivo motion in the porcine knee: Examining force during the initial cycles

2014 ◽  
Vol 32 (11) ◽  
pp. 1458-1463 ◽  
Author(s):  
Daniel V. Boguszewski ◽  
Christopher T. Wagner ◽  
David L. Butler ◽  
Jason T. Shearn
Keyword(s):  
Graft Material ◽  
Acl Graft ◽  
Joint Forces ◽  
Porcine Knee

scholarly journals Tissue-engineered Oral Mucosa

2012 ◽  
Vol 91 (7) ◽  
pp. 642-650 ◽  
Author(s):  
K. Moharamzadeh ◽  
H. Colley ◽  
C. Murdoch ◽  
V. Hearnden ◽  
W.L. Chai ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Oral Mucosa ◽  
Dental Materials ◽  
Three Dimensional ◽  
Bacterial Invasion ◽  
Graft Material ◽  
Oral Diseases

Advances in tissue engineering have permitted the three-dimensional (3D) reconstruction of human oral mucosa for various in vivo and in vitro applications. Tissue-engineered oral mucosa have been further optimized in recent years for clinical applications as a suitable graft material for intra-oral and extra-oral repair and treatment of soft-tissue defects. Novel 3D in vitro models of oral diseases such as cancer, Candida, and bacterial invasion have been developed as alternatives to animal models for investigation of disease phenomena, their progression, and treatment, including evaluation of drug delivery systems. The introduction of 3D oral mucosal reconstructs has had a significant impact on the approaches to biocompatibility evaluation of dental materials and oral healthcare products as well as the study of implant-soft tissue interfaces. This review article discusses the recent advances in tissue engineering and applications of tissue-engineered human oral mucosa.

In vivo and in vitro Examination of the Tendinous Inscription of the Human Semitendinosus Muscle

2012 ◽  
Vol 195 (4) ◽  
pp. 365-376 ◽  
Author(s):  
Eleftherios Kellis ◽  
Nikiforos Galanis ◽  
Konstantinos Natsis ◽  
George Kapetanos
Keyword(s):  
Semitendinosus Muscle ◽  
In Vitro Examination

scholarly journals Enhanced BMP-2-Mediated Bone Repair Using an Anisotropic Silk Fibroin Scaffold Coated with Bone-like Apatite

2021 ◽  
Vol 23 (1) ◽  
pp. 283
Author(s):  
Christian Deininger ◽  
Andrea Wagner ◽  
Patrick Heimel ◽  
Elias Salzer ◽  
Xavier Monforte Vila ◽  
...  
Keyword(s):  
Bone Repair ◽  
Bone Morphogenetic Protein 2 ◽  
Great Promise ◽  
Calcium Phosphate Coating ◽  
Graft Material ◽  
Morphogenetic Protein ◽  
Silk Scaffolds ◽  
Cost Efficient

The repair of large bone defects remains challenging and often requires graft material due to limited availability of autologous bone. In clinical settings, collagen sponges loaded with excessive amounts of bone morphogenetic protein 2 (rhBMP-2) are occasionally used for the treatment of bone non-unions, increasing the risk of adverse events. Therefore, strategies to reduce rhBMP-2 dosage are desirable. Silk scaffolds show great promise due to their favorable biocompatibility and their utility for various biofabrication methods. For this study, we generated silk scaffolds with axially aligned pores, which were subsequently treated with 10× simulated body fluid (SBF) to generate an apatitic calcium phosphate coating. Using a rat femoral critical sized defect model (CSD) we evaluated if the resulting scaffold allows the reduction of BMP-2 dosage to promote efficient bone repair by providing appropriate guidance cues. Highly porous, anisotropic silk scaffolds were produced, demonstrating good cytocompatibility in vitro and treatment with 10× SBF resulted in efficient surface coating. In vivo, the coated silk scaffolds loaded with a low dose of rhBMP-2 demonstrated significantly improved bone regeneration when compared to the unmineralized scaffold. Overall, our findings show that this simple and cost-efficient technique yields scaffolds that enhance rhBMP-2 mediated bone healing.

scholarly journals Role of Stem Cells in Augmenting Dental Implant Osseointegration: A Systematic Review

Coatings ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1035
Author(s):  
Mohammed E. Sayed ◽  
Maryam H. Mugri ◽  
Mazen A. Almasri ◽  
Manea Musa Al-Ahmari ◽  
Shilpa Bhandi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Bone Formation ◽  
Dental Implants ◽  
Mesenchymal Cells ◽  
Graft Material ◽  
Implant Surface ◽  
Oral Rehabilitation

Dental implants are a widely used treatment modality for oral rehabilitation. Implant failures can be a result of many factors, with poor osseointegration being the main culprit. The present systematic review aimed to assess the effect of stem cells on the osseointegration of dental implants. An electronic search of the MEDLINE, LILACS, and EMBASE databases was conducted. We examined quantitative preclinical studies that reported on the effect of mesenchymal stem cells on bone healing after implant insertion. Eighteen studies that fulfilled the inclusion criteria were included. Various surface modification strategies, sites of placement, and cell origins were analyzed. The majority of the selected studies showed a high risk of bias, indicating that caution must be exercised in their interpretation. All the included studies reported that the stem cells used with graft material and scaffolds promoted osseointegration with higher levels of new bone formation. The mesenchymal cells attached to the implant surface facilitated the expression of bio-functionalized biomaterial surfaces, to boost bone formation and osseointegration at the bone–implant interfaces. There was a promotion of osteogenic differentiation of human mesenchymal cells and osseointegration of biomaterial implants, both in vitro and in vivo. These results highlight the significance of biomodified implant surfaces that can enhance osseointegration. These innovations can improve the stability and success rate of the implants used for oral rehabilitation.

Diameter and Pulsatile Oscillations of the Femoral Artery Recorded by Ultrasound

1984 ◽  
Vol 25 (4) ◽  
pp. 313-316 ◽  
Author(s):  
T. Christensen ◽  
J. Jørgensen ◽  
B. Neubauer
Keyword(s):  
Arterial Wall ◽  
External Iliac Artery ◽  
Non Invasive ◽  
Time Motion ◽  
Invasive Method ◽  
Inner Diameter ◽  
In Vitro Examination

A new non-invasive method for in vivo investigations of the inner diameter and pulsatile oscillations of large muscular arteries by means of an ultrasound time-motion technique is presented. Each histologic layer of the arterial wall is identified at in vitro examination of the external iliac artery. The method has been used for in vivo investigations of 16 long term diabetics and of 16 non-diabetics. A reduction of the lumen and decrement in pulse deflections were found in the diabetics when compared with those of the normal group.

Cardiovascular collapse induced by Echis ocellatus venom: an in vivo and in vitro examination

Toxicon ◽  
2019 ◽  
Vol 159 ◽  
pp. S14-S15
Author(s):  
Rahini Ragavan ◽  
Anjana Silva ◽  
Barbara Kemp-Harper ◽  
Sanjaya Kuruppu ◽  
Geoffrey K. Isbister ◽  
...  
Keyword(s):  
Cardiovascular Collapse ◽  
In Vitro Examination

scholarly journals In-vivo and In-Vitro Examination of the Effect of Lucilia Sericata Larvae and Secretions on the Bacteria in Open Wounds

2020 ◽  
Vol 5 (2) ◽  
pp. 113-116
Author(s):  
Erdal Polat ◽  
◽  
Dilek Bolaban ◽  
Serhat Sirekbasan ◽  
◽  
...  
Keyword(s):  
Lucilia Sericata ◽  
In Vitro Examination
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