Effect of ACL graft material on joint forces during a simulated in vivo motion in the porcine knee: Examining force during the initial cycles

2014 ◽  
Vol 32 (11) ◽  
pp. 1458-1463 ◽  
Author(s):  
Daniel V. Boguszewski ◽  
Christopher T. Wagner ◽  
David L. Butler ◽  
Jason T. Shearn
Keyword(s):  
Graft Material ◽  
Acl Graft ◽  
Joint Forces ◽  
Porcine Knee

Platelet Adhesion in Polytetrafluoroethylene (PTFE) Vascular Grafts In Vivo and the Influence of Increased Intramuscular Pressure-An Experimental Model

1983 ◽  
Vol 50 (04) ◽  
pp. 881-884 ◽  
Author(s):  
J T Christenson ◽  
P Qvarfordt ◽  
S-E Strand ◽  
D Arvidsson ◽  
T Sjöberg ◽  
...  
Keyword(s):  
Blood Flow ◽  
Graft Failure ◽  
Small Diameter ◽  
Graft Material ◽  
Intramuscular Pressure ◽  
Initial Flow ◽  
Early Graft ◽  
Wick Technique ◽  
Early Graft Failure

SummaryThrombogenicity of graft material is involved in early graft failure in small diameter grafts. The frequently seen postoperative swelling of the leg after distal revascularization may cause an increased intramuscular pressure and early graft failure.Pairs of 4 mm polytetrafluoroethylene (PTFE) grafts were implanted. Autologous platelets were labeled with mIn-oxine. Platelet adhesiveness onto the grafts were analyzed from gamma camera images. Intramuscular pressures were measured with wick technique. Blood flow was measured. One graft served as control the other as test graft. Ninety minutes after declamping the i. m. pressure was increased in the test-leg to 30 mmHg, and later to 60 mmHg.In the control-graft platelet uptake increased to a maximum 60 min after declamping. Blood flow and i.m. pressure remained uneffected. The test-grafts were initially similar but when i.m. pressure was increased to 30 mmHg activity in the grafts increased significantly. Blood flow decreased with 12% of initial flow. When i. m. pressure was raised to 60 mmHg platelet uptake continued to increase.An increased intramuscular pressure of 30 mmHg or more significantly increase the amount of platelets adhering onto PTFE grafts, emphasizing the need for measuring intramuscular pressures after lower limb vascular revascularizations.

Assessment of α-calcium sulfate hemihydrate/nanocellulose composite bone graft material for bone healing in a rabbit femoral condyle model

2021 ◽  
Vol 11 (9) ◽  
pp. 1497-1504
Author(s):  
Jinlong Liu ◽  
Yicai Zhang ◽  
Lin Qiu ◽  
Yujuan Zhang ◽  
Bin Gao
Keyword(s):  
Bone Graft ◽  
Calcium Sulfate ◽  
Biological Activities ◽  
Femoral Condyle ◽  
Three Dimensional ◽  
Graft Material ◽  
Bone Graft Material ◽  
Calcium Sulfate Hemihydrate ◽  
Composite Bone

The material properties of nanocellulose (NC) can effectively enhance the structural stability of composite materials. However, the research related to NC/α-calcium sulfate hemihydrate (CSH) composites is largely lacking. In this paper, we explore the combination of these two materials and determine their elaborate biological activities in vivo. Using α-CSH as the matrix, the composite bone graft materials were produced according to different proportions of NC. Then the mechanical strength of the composite bone graft was measured, and the results were analyzed by X-ray diffraction and scanning electron microscopy (SEM). To conduct the material in vivo evaluation, 0% (CN0) and 0.75% (CN0.75) NC/α-CSH composite bone graft materials were implanted into a femoral condyle defect model. The results indicated that NC could significantly enhance the mechanical properties of α-CSH. The SEM analysis indicated that the NC shuttled between the crystal gaps and formed a three-dimensional network structure, which was firmly combined with the crystal structure. Meanwhile, the CN0.75 scaffold remained at 12 weeks postoperation, which provided a long-term framework for new bone formation. Overall, our findings demonstrate that, with a 0.75% NC/α-CSH composite demonstrating good potential as a bone graft material for clinical bone grafting.

IN VIVO SHOULDER JOINT FORCES AT ISOLATED MOTIONS

2008 ◽  
Vol 41 ◽  
pp. S144 ◽  
Author(s):  
Peter Westerhoff ◽  
Antonius Rohlmann ◽  
A. Bender ◽  
Friedmar Graichen ◽  
Georg Bergmann
Keyword(s):  
Shoulder Joint ◽  
Joint Forces

In Vivo Evaluation of Anterior Cervical Fusions with Hydroxylapatite Graft Material

Spine ◽  
1994 ◽  
Vol 19 (16) ◽  
pp. 1856-1866 ◽  
Author(s):  
Stephen D. Cook ◽  
Jeanette E. Dalton ◽  
Edward H. Tan ◽  
William V. Tejeiro ◽  
Michael J. Young ◽  
...  
Keyword(s):  
Graft Material ◽  
In Vivo Evaluation

Self-Expandable Thin Film Nitinol Endografts for Vascular Repair: Manufacturing and Short-Term Results in Swine

2009 ◽  
Author(s):  
Youngjae Chun ◽  
Daniel S. Levi ◽  
K. P. Mohanchandra ◽  
Gregory P. Carman
Keyword(s):  
Thin Film ◽  
Layer Growth ◽  
Sputter Deposition ◽  
In Vivo Studies ◽  
Graft Material ◽  
Vascular Repair ◽  
Short Term ◽  
Strain Behavior ◽  
Mems Technology

A thin film nitinol covered endograft for vessel treatment was manufactured and in vivo swine testing was performed. Thin film nitinol graft material was fabricated by DC sputter deposition and stress-strain behavior and DSC characteristics were investigated. Micro size patterns were fabricated by MEMS technology in order to promote endothelial layer growth. In-vivo studies in swine were conducted to evaluate deployment, placement and patency of the implanted stent device.

scholarly journals Tissue-engineered Oral Mucosa

2012 ◽  
Vol 91 (7) ◽  
pp. 642-650 ◽  
Author(s):  
K. Moharamzadeh ◽  
H. Colley ◽  
C. Murdoch ◽  
V. Hearnden ◽  
W.L. Chai ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Oral Mucosa ◽  
Dental Materials ◽  
Three Dimensional ◽  
Bacterial Invasion ◽  
Graft Material ◽  
Oral Diseases

Advances in tissue engineering have permitted the three-dimensional (3D) reconstruction of human oral mucosa for various in vivo and in vitro applications. Tissue-engineered oral mucosa have been further optimized in recent years for clinical applications as a suitable graft material for intra-oral and extra-oral repair and treatment of soft-tissue defects. Novel 3D in vitro models of oral diseases such as cancer, Candida, and bacterial invasion have been developed as alternatives to animal models for investigation of disease phenomena, their progression, and treatment, including evaluation of drug delivery systems. The introduction of 3D oral mucosal reconstructs has had a significant impact on the approaches to biocompatibility evaluation of dental materials and oral healthcare products as well as the study of implant-soft tissue interfaces. This review article discusses the recent advances in tissue engineering and applications of tissue-engineered human oral mucosa.

scholarly journals Bone-Forming Capabilities of a Newly Developed NanoHA Composite Alloplast Infused with Collagen: A Pilot Study in the Sheep Mandible

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Charles Marin ◽  
Ryo Jimbo ◽  
Fabio Cesar Lorenzoni ◽  
Lukasz Witek ◽  
Hellen Teixeira ◽  
...  
Keyword(s):  
Bone Ingrowth ◽  
Donor Site ◽  
Three Dimensional ◽  
Polyglycolic Acid ◽  
Autogenous Bone ◽  
Graft Material ◽  
Resorption Rate ◽  
Experimental Block ◽  
The Status

Lateral or vertical bone augmentation has always been a challenge, since the site is exposed to constant pressure from the soft tissue, and blood supply only exists from the donor site. Although, for such clinical cases, onlay grafting with autogenous bone is commonly selected, the invasiveness of the secondary surgical site and the relatively fast resorption rate have been reported as a drawback, which motivated the investigation of alternative approaches. This study evaluated the bone-forming capability of a novel nanoHA alloplast infused with collagen graft material made from biodegradable polylactic acid/polyglycolic acid versus a control graft material with the same synthesized alloplast without the nanoHA component and collagen infiltration. The status of newly formed bone and the resorption of the graft material were evaluated at 6 weeksin vivohistologically and three dimensionally by means of 3D microcomputed tomography. The histologic observation showed that newly formed bone ingrowth and internal resorption of the block were observed for the experimental blocks, whereas for the control blocks less bone ingrowth occurred along with lower resorption rate of the block material. The three-dimensional observation indicated that the experimental block maintained the external geometry, but at the same time successfully altered the graft material into bone. It is suggested that the combination of numerous factors contributed to the bone ingrowth and the novel development could be an alternative bone grafting choice.

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