scholarly journals Notch signaling components are upregulated during both endochondral and intramembranous bone regeneration

2011 ◽  
Vol 30 (2) ◽  
pp. 296-303 ◽  
Author(s):  
Michael I. Dishowitz ◽  
Shawn P. Terkhorn ◽  
Sandra A. Bostic ◽  
Kurt D. Hankenson
Keyword(s):  
Notch Signaling ◽  
Bone Regeneration ◽  
Intramembranous Bone ◽  
Signaling Components

scholarly journals Notch-Wnt signal crosstalk regulates proliferation and differentiation of osteoprogenitor cells during intramembranous bone healing

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
S. Lee ◽  
L. H. Remark ◽  
A. M. Josephson ◽  
K. Leclerc ◽  
E. Muiños Lopez ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Notch Signaling ◽  
Bone Regeneration ◽  
Bone Healing ◽  
Canonical Wnt Signaling ◽  
Osteoprogenitor Cells ◽  
Intramembranous Bone ◽  
Proliferation And Differentiation ◽  
Canonical Wnt ◽  
Wnt Signal

AbstractAdult bone regeneration is orchestrated by the precise actions of osteoprogenitor cells (OPCs). However, the mechanisms by which OPC proliferation and differentiation are linked and thereby regulated are yet to be defined. Here, we present evidence that during intramembranous bone formation OPC proliferation is controlled by Notch signaling, while differentiation is initiated by activation of canonical Wnt signaling. The temporospatial separation of Notch and Wnt signal activation during the early stages of bone regeneration suggests crosstalk between the two pathways. In vitro and in vivo manipulation of the two essential pathways demonstrate that Wnt activation leads to initiation of osteogenic differentiation and at the same time inhibits Notch signaling, which results in termination of the proliferative phase. Here, we establish canonical Wnt signaling as a key regulator that facilitates the crosstalk between OPC proliferation and differentiation during intramembranous, primary bone healing.

Effect of locally administered zoledronic acid on injury-induced intramembranous bone regeneration and osseointegration of a titanium implant in rats

2009 ◽  
Vol 14 (4) ◽  
pp. 431-436 ◽  
Author(s):  
Simo S.A. Miettinen ◽  
Jarkko Jaatinen ◽  
Alpo Pelttari ◽  
Reijo Lappalainen ◽  
Jukka Mönkkönen ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Bone Regeneration ◽  
Titanium Implant ◽  
Intramembranous Bone

scholarly journals JAGGED1 stimulates cranial neural crest cell osteoblast commitment pathways and bone regeneration independent of canonical NOTCH signaling

Bone ◽  
2021 ◽  
Vol 143 ◽  
pp. 115657
Author(s):  
Archana Kamalakar ◽  
Jay M. McKinney ◽  
Daniel Salinas Duron ◽  
Angelica M. Amanso ◽  
Samir A. Ballestas ◽  
...  
Keyword(s):  
Neural Crest ◽  
Notch Signaling ◽  
Bone Regeneration ◽  
Neural Crest Cell ◽  
Cranial Neural Crest ◽  
Cranial Neural Crest Cell ◽  
Crest Cell

Intramembranous bone regeneration differs among common inbred mouse strains following marrow ablation

2015 ◽  
Vol 33 (9) ◽  
pp. 1374-1381 ◽  
Author(s):  
Meghan M. Moran ◽  
Amarjit S. Virdi ◽  
Kotaro Sena ◽  
Steven R. Mazzone ◽  
Margaret A. McNulty ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Inbred Mouse ◽  
Mouse Strains ◽  
Inbred Mouse Strains ◽  
Intramembranous Bone ◽  
Marrow Ablation

Patterns and Localization of Gene Expression During Intramembranous Bone Regeneration in the Rat Femoral Marrow Ablation Model

2005 ◽  
Vol 77 (4) ◽  
pp. 212-225 ◽  
Author(s):  
Shinji Kuroda ◽  
Amarjit S. Virdi ◽  
Yang Dai ◽  
Susan Shott ◽  
Dale R. Sumner
Keyword(s):  
Gene Expression ◽  
Bone Regeneration ◽  
Intramembranous Bone ◽  
Marrow Ablation ◽  
Ablation Model

Biomaterial-Mediated Presentation of Jagged-1 Mimetic Ligand Enhances Cellular Activation of Notch Signaling and Bone Regeneration

ACS Nano ◽  
2021 ◽  
Author(s):  
Yingrui Deng ◽  
Rui Li ◽  
Haixing Wang ◽  
Boguang Yang ◽  
Peng Shi ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Bone Regeneration ◽  
Cellular Activation

scholarly journals Suppression of Notch Signaling in Osteoclasts Improves Bone Regeneration and Healing

2019 ◽  
Vol 37 (10) ◽  
pp. 2089-2103 ◽  
Author(s):  
Peeyush N. Goel ◽  
Yasaman Moharrer ◽  
John H. Hebb ◽  
Alexander J. Egol ◽  
Gurpreet Kaur ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Bone Regeneration
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