P2X4 receptor in the dorsal horn partially contributes to brain-derived neurotrophic factor oversecretion and toll-like receptor-4 receptor activation associated with bone cancer pain

2014 ◽  
Vol 92 (12) ◽  
pp. 1690-1702 ◽  
Author(s):  
Xiao-hong Jin ◽  
Li-Na Wang ◽  
Jian-Ling Zuo ◽  
Jian-Ping Yang ◽  
Si-lan Liu
Keyword(s):  
Cancer Pain ◽  
Dorsal Horn ◽  
Neurotrophic Factor ◽  
Bone Cancer ◽  
Brain Derived Neurotrophic Factor ◽  
Receptor Activation ◽  
Bone Cancer Pain ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
P2x4 Receptor

scholarly journals Up-regulation of brain-derived neurotrophic factor in the dorsal root ganglion of the rat bone cancer pain model

2014 ◽  
pp. 415 ◽  
Author(s):  
Naoto Tomotsuka ◽  
Ryuji Kaku ◽  
Norihiko Obata ◽  
Yoshikazu Matsuoka ◽  
Hirotaka Kanzaki ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Cancer Pain ◽  
Neurotrophic Factor ◽  
Dorsal Root ◽  
Bone Cancer ◽  
Brain Derived Neurotrophic Factor ◽  
Bone Cancer Pain ◽  
Pain Model ◽  
Rat Bone

scholarly journals Down-Regulation of Toll-Like Receptor 4 Gene Expression by Short Interfering RNA Attenuates Bone Cancer Pain in a Rat Model

2010 ◽  
Vol 6 ◽  
pp. 1744-8069-6-2 ◽  
Author(s):  
Liu Si Lan ◽  
Yang Jian Ping ◽  
Wang Li Na ◽  
Jiang Miao ◽  
Qiu Qiao Cheng ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cancer Pain ◽  
Rat Model ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Short Interfering Rna ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Down Regulation ◽  
Interfering Rna

Connexin 43 Mediates CXCL12 Production from Spinal Dorsal Horn to Maintain Bone Cancer Pain in Rats

2015 ◽  
Vol 41 (5) ◽  
pp. 1200-1208 ◽  
Author(s):  
Li-Hua Hang ◽  
Shu-Na Li ◽  
Hong Luo ◽  
Wei-Wei Shu ◽  
Zu-Min Mao ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Dorsal Horn ◽  
Connexin 43 ◽  
Spinal Dorsal Horn ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Spinal Dorsal

The bone cancer pain induced expression of NR1 and NOS on the dorsal horn of murine spinal cord

2008 ◽  
Vol 32 (3) ◽  
pp. S65-S66
Author(s):  
Dong Huang ◽  
Shai Hong Zhu ◽  
Xiao Ling Huang ◽  
Jing Song Zeng ◽  
Yong Hong Gu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cancer Pain ◽  
Dorsal Horn ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Induced Expression

scholarly journals Neuroligins Facilitate The Development of Bone Cancer Pain via Regulating Synaptic Transmission

2021 ◽  
Author(s):  
Xianqiao Xie ◽  
Yang Li ◽  
Shanchun Su ◽  
Xiaohui Li ◽  
Xueqin Xu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Chronic Pain ◽  
Cancer Pain ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Rat Spinal Cord ◽  
Spinal Dorsal

Abstract Background The underlying mechanism of chronic pain involves the plasticity in synaptic receptors and neurotransmitters. This study aimed to investigate potential roles of neuroligins (NLs) within the spinal dorsal horn of rats in a newly established bone cancer pain (BCP) model. Methods Using our rat BCP model, we assessed pain hypersensitivity over time. Quantitative real-time polymerase chain reaction and Western blot analysis were performed to investigate NL expression, and NLs were overexpressed in the rat spinal cord using lentiviral vectors. Immunofluorescence staining and whole-cell patch-clamp recordings were deployed to investigate the role of NLs in the development of BCP. Results We observed reduced expression levels of NL1 and NL2, but not NL3, within the rat spinal cord, which were found to be associated with and essential for the development of BCP in our model. Accordingly, NL1 or NL2 overexpression in the spinal cord alleviated mechanical hypersensitivity of rats. Electrophysiological experiments indicated that NL1 and NL2 are involved in BCP via regulating γ-aminobutyric acid-ergic interneuronal synapses and the activity of glutamatergic interneuronal synapses, respectively. Conclusions Our observations unravel the role of NLs in cancer-related chronic pain and further suggest that inhibitory mechanisms are central features of BCP in the spinal dorsal horn. These results provide a new perspective and basis for subsequent studies elucidating the onset and progression of BCP.

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