scholarly journals Electrical peripheral nerve stimulation relieves bone cancer pain by inducing Arc protein expression in the spinal cord dorsal horn

2018 ◽  
Vol Volume 11 ◽  
pp. 599-609 ◽  
Author(s):  
Ke-fu Sun ◽  
Wan-wen Feng ◽  
Yue-peng Liu ◽  
Yan-bin Dong ◽  
Li Gao ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Peripheral Nerve ◽  
Protein Expression ◽  
Cancer Pain ◽  
Dorsal Horn ◽  
Nerve Stimulation ◽  
Bone Cancer ◽  
Spinal Cord Dorsal Horn ◽  
Bone Cancer Pain ◽  
Spinal Cord Dorsal

scholarly journals DNMT3a contributes to the development and maintenance of bone cancer pain by silencing Kv1.2 expression in spinal cord dorsal horn

2017 ◽  
Vol 13 ◽  
pp. 174480691774068 ◽  
Author(s):  
Xue-Rong Miao ◽  
Long-Chang Fan ◽  
Shaogen Wu ◽  
Qing-Xiang Mao ◽  
Zhen Li ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cancer Pain ◽  
Dorsal Horn ◽  
Bone Cancer ◽  
Spinal Cord Dorsal Horn ◽  
Bone Cancer Pain ◽  
Spinal Cord Dorsal

scholarly journals Proteome of synaptosome-associated proteins in spinal cord dorsal horn after peripheral nerve injury

PROTEOMICS ◽  
2009 ◽  
Vol 9 (5) ◽  
pp. 1241-1253 ◽  
Author(s):  
Om V. Singh ◽  
Myron Yaster ◽  
Ji-Tian Xu ◽  
Yun Guan ◽  
Xiaowei Guan ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Peripheral Nerve ◽  
Dorsal Horn ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Spinal Cord Dorsal Horn ◽  
Associated Proteins ◽  
Spinal Cord Dorsal

The bone cancer pain induced expression of NR1 and NOS on the dorsal horn of murine spinal cord

2008 ◽  
Vol 32 (3) ◽  
pp. S65-S66
Author(s):  
Dong Huang ◽  
Shai Hong Zhu ◽  
Xiao Ling Huang ◽  
Jing Song Zeng ◽  
Yong Hong Gu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cancer Pain ◽  
Dorsal Horn ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Induced Expression

scholarly journals Neuroligins Facilitate The Development of Bone Cancer Pain via Regulating Synaptic Transmission

2021 ◽  
Author(s):  
Xianqiao Xie ◽  
Yang Li ◽  
Shanchun Su ◽  
Xiaohui Li ◽  
Xueqin Xu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Chronic Pain ◽  
Cancer Pain ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Rat Spinal Cord ◽  
Spinal Dorsal

Abstract Background The underlying mechanism of chronic pain involves the plasticity in synaptic receptors and neurotransmitters. This study aimed to investigate potential roles of neuroligins (NLs) within the spinal dorsal horn of rats in a newly established bone cancer pain (BCP) model. Methods Using our rat BCP model, we assessed pain hypersensitivity over time. Quantitative real-time polymerase chain reaction and Western blot analysis were performed to investigate NL expression, and NLs were overexpressed in the rat spinal cord using lentiviral vectors. Immunofluorescence staining and whole-cell patch-clamp recordings were deployed to investigate the role of NLs in the development of BCP. Results We observed reduced expression levels of NL1 and NL2, but not NL3, within the rat spinal cord, which were found to be associated with and essential for the development of BCP in our model. Accordingly, NL1 or NL2 overexpression in the spinal cord alleviated mechanical hypersensitivity of rats. Electrophysiological experiments indicated that NL1 and NL2 are involved in BCP via regulating γ-aminobutyric acid-ergic interneuronal synapses and the activity of glutamatergic interneuronal synapses, respectively. Conclusions Our observations unravel the role of NLs in cancer-related chronic pain and further suggest that inhibitory mechanisms are central features of BCP in the spinal dorsal horn. These results provide a new perspective and basis for subsequent studies elucidating the onset and progression of BCP.

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