Increased aquaporin-1 and Na+-K+-2Cl- cotransporter 1 expression in choroid plexus leads to blood-cerebrospinal fluid barrier disruption and necrosis of hippocampal CA1 cells in acute rat models of hyponatremia

2012 ◽  
Vol 90 (7) ◽  
pp. 1437-1444 ◽  
Author(s):  
Jaehyun Kim ◽  
Yongwook Jung
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Rat Models ◽  
Aquaporin 1 ◽  
Barrier Disruption ◽  
Hippocampal Ca1 ◽  
Ca1 Cells

Oxidative stress in the choroid plexus contributes to blood–cerebrospinal fluid barrier disruption during sepsis development

2019 ◽  
Vol 123 ◽  
pp. 19-24 ◽  
Author(s):  
Mariana Pereira Goldim ◽  
Lucineia Gainski Danielski ◽  
Judite Filgueiras Rodrigues ◽  
Larissa Joaquim ◽  
Leandro Garbossa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Barrier Disruption

scholarly journals High Blood Pressure Effects on the Blood to Cerebrospinal Fluid Barrier and Cerebrospinal Fluid Protein Composition: A Two-Dimensional Electrophoresis Study in Spontaneously Hypertensive Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Ibrahim González-Marrero ◽  
Leandro Castañeyra-Ruiz ◽  
Juan M. González-Toledo ◽  
Agustín Castañeyra-Ruiz ◽  
Hector de Paz-Carmona ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Protein Composition ◽  
Pressure Effects ◽  
Apolipoprotein A1 ◽  
Spontaneously Hypertensive ◽  
Barrier Disruption ◽  
Cerebrospinal Fluid Proteins ◽  
The Brain ◽  
Cerebrospinal Fluid Protein

The aim of the present work is to analyze the cerebrospinal fluid proteomic profile, trying to find possible biomarkers of the effects of hypertension of the blood to CSF barrier disruption in the brain and their participation in the cholesterol andβ-amyloid metabolism and inflammatory processes. Cerebrospinal fluid (CSF) is a system linked to the brain and its composition can be altered not only by encephalic disorder, but also by systemic diseases such as arterial hypertension, which produces alterations in the choroid plexus and cerebrospinal fluid protein composition. 2D gel electrophoresis in cerebrospinal fluid extracted from the cistern magna before sacrifice of hypertensive and control rats was performed. The results showed different proteomic profiles between SHR and WKY, thatα-1-antitrypsin, apolipoprotein A1, albumin, immunoglobulin G, vitamin D binding protein, haptoglobin andα-1-macroglobulin were found to be up-regulated in SHR, and apolipoprotein E, transthyretin,α-2-HS-glycoprotein, transferrin,α-1β-glycoprotein, kininogen and carbonic anhidrase II were down-regulated in SHR. The conclusion made here is that hypertension in SHR produces important variations in cerebrospinal fluid proteins that could be due to a choroid plexus dysfunction and this fact supports the close connection between hypertension and blood to cerebrospinal fluid barrier disruption.

Choroid Plexus and Aquaporin-1: A Novel Explanation of Cerebrospinal Fluid Production

2004 ◽  
Vol 40 (6) ◽  
pp. 277-283 ◽  
Author(s):  
P.L. Longatti ◽  
L. Basaldella ◽  
E. Orvieto ◽  
A. Fiorindi ◽  
A. Carteri
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Aquaporin 1 ◽  
Fluid Production

Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin‐1

2004 ◽  
Vol 19 (1) ◽  
pp. 76-78 ◽  
Author(s):  
Kotaro Oshio ◽  
Hiroyuki Watanabe ◽  
Yaunlin Song ◽  
A. S. Verkman ◽  
Geoffrey T. Manley
Keyword(s):  
Cerebrospinal Fluid ◽  
Intracranial Pressure ◽  
Choroid Plexus ◽  
Water Channel ◽  
Aquaporin 1 ◽  
Fluid Production

Sex-Related Differences in Rat Choroid Plexus and Cerebrospinal Fluid: A cDNA Microarray and Proteomic Analysis

2016 ◽  
Vol 28 (1) ◽  
Author(s):  
T. Quintela ◽  
H. Marcelino ◽  
M. J. Deery ◽  
R. Feret ◽  
J. Howard ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Cdna Microarray ◽  
Proteomic Analysis

Surgical removal of bilateral papillomas of the choroid plexus of the lateral ventricles with resolution of hydrocephalus

1979 ◽  
Vol 50 (5) ◽  
pp. 677-681 ◽  
Author(s):  
Steven K. Gudeman ◽  
Humbert G. Sullivan ◽  
Michael J. Rosner ◽  
Donald P. Becker
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Large Volume ◽  
Surgical Removal ◽  
Tumor Removal ◽  
Content Type ◽  
Lateral Ventricles ◽  
Csf Diversion ◽  
Csf Production ◽  
Fine Print

✓ The authors report a patient with bilateral papillomas of the choroid plexus of the lateral ventricles with documentation of cerebrospinal fluid (CSF) hypersecretion causing hydrocephalus. Special attention is given to the large volume of CSF produced by these tumors (removal of one tumor reduced CSF outflow by one-half) and to the fact that CSF diversion was not required after both tumors were removed. Since tumor removal alone was sufficient to stop the progression of hydrocephalus, we feel that this case supports the concept that elevated CSF production by itself is sufficient to cause hydrocephalus in patients with papillomas of the choroid plexus.

Cardiotrophin-1 in choroid plexus and the cerebrospinal fluid circulatory system

Neuroscience ◽  
2004 ◽  
Vol 127 (1) ◽  
pp. 43-52 ◽  
Author(s):  
A.L Gard ◽  
E Gavin ◽  
V Solodushko ◽  
D Pennica
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Circulatory System

scholarly journals The choroid plexus sodium-bicarbonate cotransporter NBCe2 regulates mouse cerebrospinal fluid pH

2018 ◽  
Vol 596 (19) ◽  
pp. 4709-4728 ◽  
Author(s):  
Henriette L. Christensen ◽  
Dagne Barbuskaite ◽  
Aleksandra Rojek ◽  
Hans Malte ◽  
Inga B. Christensen ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Sodium Bicarbonate ◽  
Choroid Plexus ◽  
Sodium Bicarbonate Cotransporter
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