Choroid Plexus and Aquaporin-1: A Novel Explanation of Cerebrospinal Fluid Production

2004 ◽  
Vol 40 (6) ◽  
pp. 277-283 ◽  
Author(s):  
P.L. Longatti ◽  
L. Basaldella ◽  
E. Orvieto ◽  
A. Fiorindi ◽  
A. Carteri
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Aquaporin 1 ◽  
Fluid Production

Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin‐1

2004 ◽  
Vol 19 (1) ◽  
pp. 76-78 ◽  
Author(s):  
Kotaro Oshio ◽  
Hiroyuki Watanabe ◽  
Yaunlin Song ◽  
A. S. Verkman ◽  
Geoffrey T. Manley
Keyword(s):  
Cerebrospinal Fluid ◽  
Intracranial Pressure ◽  
Choroid Plexus ◽  
Water Channel ◽  
Aquaporin 1 ◽  
Fluid Production

The Cerebrospinal Fluid: Production, Circulation, and Absorption, Ciba Foundation Symposium

PEDIATRICS ◽  
1958 ◽  
Vol 22 (6) ◽  
pp. 1152-1152
Author(s):  
JONATHAN T. LANMAN
Keyword(s):  
Cerebrospinal Fluid ◽  
Electron Microscope ◽  
Choroid Plexus ◽  
Early Development ◽  
Clinical Medicine ◽  
Ciba Foundation Symposium ◽  
Fluid Production

This Ciba Symposium records the proceedings of a meeting held in London in May, 1957 to discuss the cerebrospinal fluid. The papers presented may be roughly grouped in the fields of anatomy, physiology, and clinical medicine. Those in the field of anatomy are excellent and in keeping with the current renaissance in this field. They include observations on the early development of the telencephalic choroid plexus, suggesting a progression of diverse functions for this tissue during ontogeny, and a study of the mature choroid plexus using the electron microscope.

Cerebrospinal Fluid Production by the Choroid Plexus and Brain

Science ◽  
1971 ◽  
Vol 173 (3994) ◽  
pp. 330-332 ◽  
Author(s):  
T. H. Milhorat ◽  
M. K. Hammock ◽  
J. D. Fenstermacher ◽  
D. P. Rall ◽  
V. A. Levin
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Fluid Production

Sympathetic nervous control of cerebrospinal fluid production from the choroid plexus

Science ◽  
1978 ◽  
Vol 201 (4351) ◽  
pp. 176-178 ◽  
Author(s):  
M Lindvall ◽  
L Edvinsson ◽  
C Owman
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Nervous Control ◽  
Fluid Production ◽  
Sympathetic Nervous

Cerebrospinal fluid production and its relationship to cerebral metabolism and cerebral blood flow

1959 ◽  
Vol 197 (4) ◽  
pp. 825-828 ◽  
Author(s):  
Edgar A. Bering
Keyword(s):  
Blood Flow ◽  
Cerebrospinal Fluid ◽  
Cerebral Blood Flow ◽  
Oxygen Consumption ◽  
Choroid Plexus ◽  
Cerebral Metabolism ◽  
Oxygen Metabolism ◽  
Csf Flow ◽  
Constant Composition ◽  
Fluid Production

The cerebrospinal fluid production has been studied in the dog under conditions of maximum obtainable flow rates from the cisterna magna. Under these conditions the fluid had constant composition and was assumed to represent the cerebrospinal fluid in the intact state. Cerebral blood flow and cerebral oxygen consumption were measured by the method of Kety and Schmidt. The only significant correlations found were with oxygen consumption when the CSF flow rate was in terms of brain weight and with cerebral blood flow and cerebral vascular resistance when CSF flow was in terms of choroid plexus weight. A combined regression equation was calculated which satisfactorily accounted for the observed CSF flow: CSF cu mm/min. = .128 x CMRO2 x brain wgt. + 0.15 x CVR x choroid plexus wt. This suggested separate physiological processes, one correlated with oxygen metabolism and one with hydrodynamic factors of the cerebral blood flow. The data demonstrated that the choroid plexus alone could not have accounted for the entire CSF flow and some must have come from another source, presumably the brain.

Choroid Plexus and Cerebrospinal Fluid Production

Science ◽  
1969 ◽  
Vol 166 (3912) ◽  
pp. 1514-1516 ◽  
Author(s):  
T. H. Milhorat
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Fluid Production

ATP-stimulated adenylic acid deaminase activity at site of aqueous humor production

1960 ◽  
Vol 198 (3) ◽  
pp. 665-668 ◽  
Author(s):  
Morton B. Waitzman
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Aqueous Humor ◽  
Adenine Nucleotide ◽  
Amp Deaminase ◽  
Active System ◽  
Ciliary Process ◽  
General Acceptance ◽  
Adenylic Acid ◽  
Fluid Production

A specific 5-adenylic acid (5-AMP) deaminase was studied in preparations of hog ciliary process tissue. It was determined that while the activity of this deaminase is enhanced by adenosinetriphosphate (ATP), this activity is not completely blocked in the absence of ATP. Deamination proceeds only at the expense of 5-AMP, but a myokinase-like-active system may be prepared, such that 5-AMP is added to the substrate pool. In this latter case total levels of deamination are generally reflective of added 5-AMP and myokinase-like reaction accumulated 5-AMP. The general acceptance of ciliary process tissue as the site of aqueous humor production leads one to a reasonable conclusion that the very active 5-AMP deaminase studied plays some as yet unexplained role in the dynamics of aqueous secretion. Possibilities concerning the specific role(s) played are discussed. Functional analogy between aqueous humor and cerebrospinal fluid production is again suggested by the fact that an adenine nucleotide deaminase is found also in choroid plexus tissue.

Role of NaCl cotransport in cerebrospinal fluid production: effects of loop diuretics

1991 ◽  
Vol 71 (3) ◽  
pp. 795-800 ◽  
Author(s):  
S. Javaheri
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Ionic Composition ◽  
Reasonable Assumption ◽  
Cerebral Ventricles ◽  
Fluid Production ◽  
Production Effects ◽  
Nacl Cotransport ◽  
Csf Production

Cerebrospinal fluid (CSF) is secreted primarily by the choroid plexus (CP) located in the cerebral ventricles. Although much is known about ionic composition of cisternal CSF, the mechanisms involved in secretion of CSF in mammals are still not understood. The main aim of this report is to critically review the role of NaCl cotransport carrier in CSF production. On the basis of the studies in the literature, a model for CSF production by the CP is proposed. In this model, CP cells are assumed to be equipped with an NaCl cotransport carrier located on the basolateral (blood-facing) membrane. Because Na+ and Cl- are the two principal ions in CSF, their continued secretions into cerebral ventricles by CP cells require an adequate intracellular supply, which may be guaranteed by the NaCl cotransport carrier. Although this appears to be a reasonable assumption, making the processes involved in CSF production similar to those of other secretory epithelial cells, the presence of such a carrier in mammalian CP remains controversial. The reasons for this controversy are critically reviewed, and some suggestions for further studies are made.

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