Sex-Related Differences in Rat Choroid Plexus and Cerebrospinal Fluid: A cDNA Microarray and Proteomic Analysis

2016 ◽  
Vol 28 (1) ◽  
Author(s):  
T. Quintela ◽  
H. Marcelino ◽  
M. J. Deery ◽  
R. Feret ◽  
J. Howard ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Cdna Microarray ◽  
Proteomic Analysis

scholarly journals A Proteomic Analysis of Individual and Gender Variations in Normal Human Urine and Cerebrospinal Fluid Using iTRAQ Quantification

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0133270 ◽  
Author(s):  
Zhengguang Guo ◽  
Yang Zhang ◽  
Lili Zou ◽  
Danqi Wang ◽  
Chen Shao ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Human Urine ◽  
Proteomic Analysis ◽  
Normal Human ◽  
And Gender ◽  
Gender Variations

Surgical removal of bilateral papillomas of the choroid plexus of the lateral ventricles with resolution of hydrocephalus

1979 ◽  
Vol 50 (5) ◽  
pp. 677-681 ◽  
Author(s):  
Steven K. Gudeman ◽  
Humbert G. Sullivan ◽  
Michael J. Rosner ◽  
Donald P. Becker
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Large Volume ◽  
Surgical Removal ◽  
Tumor Removal ◽  
Content Type ◽  
Lateral Ventricles ◽  
Csf Diversion ◽  
Csf Production ◽  
Fine Print

✓ The authors report a patient with bilateral papillomas of the choroid plexus of the lateral ventricles with documentation of cerebrospinal fluid (CSF) hypersecretion causing hydrocephalus. Special attention is given to the large volume of CSF produced by these tumors (removal of one tumor reduced CSF outflow by one-half) and to the fact that CSF diversion was not required after both tumors were removed. Since tumor removal alone was sufficient to stop the progression of hydrocephalus, we feel that this case supports the concept that elevated CSF production by itself is sufficient to cause hydrocephalus in patients with papillomas of the choroid plexus.

Cardiotrophin-1 in choroid plexus and the cerebrospinal fluid circulatory system

Neuroscience ◽  
2004 ◽  
Vol 127 (1) ◽  
pp. 43-52 ◽  
Author(s):  
A.L Gard ◽  
E Gavin ◽  
V Solodushko ◽  
D Pennica
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Circulatory System

scholarly journals Identification of Tumor-Related Proteins by Proteomic Analysis of Cerebrospinal Fluid from Patients with Primary Brain Tumors

2003 ◽  
Vol 62 (8) ◽  
pp. 855-862 ◽  
Author(s):  
Ping-Pin Zheng ◽  
Theo M. Luider ◽  
Rob Pieters ◽  
Cees J.J. Avezaat ◽  
Martin J. van den Bent ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Brain Tumors ◽  
Proteomic Analysis ◽  
Primary Brain Tumors ◽  
Related Proteins

scholarly journals The choroid plexus sodium-bicarbonate cotransporter NBCe2 regulates mouse cerebrospinal fluid pH

2018 ◽  
Vol 596 (19) ◽  
pp. 4709-4728 ◽  
Author(s):  
Henriette L. Christensen ◽  
Dagne Barbuskaite ◽  
Aleksandra Rojek ◽  
Hans Malte ◽  
Inga B. Christensen ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Sodium Bicarbonate ◽  
Choroid Plexus ◽  
Sodium Bicarbonate Cotransporter

scholarly journals OTX2 homeoprotein functions in adult choroid plexus

2021 ◽  
Author(s):  
Anabelle Planques ◽  
Vanessa Oliveira Moreira ◽  
David Benacom ◽  
Clémence Bernard ◽  
Laurent Jourdren ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Choroid Plexus ◽  
Stress Responses ◽  
Subventricular Zone ◽  
Adult Mouse ◽  
Mass Spectrometry Analysis ◽  
Mrna Isoforms ◽  
Spectrometry Analysis ◽  
Protein Partners ◽  
Brain Homeostasis

AbstractChoroid plexus secretes cerebrospinal fluid important for brain development and homeostasis. The OTX2 homeoprotein is critical for choroid plexus development and remains highly expressed in adult choroid plexus. Through RNA sequencing analyses of constitutive and conditional knockdown adult mouse models, we reveal putative roles for OTX2 in choroid plexus function, including cell signaling and adhesion, and show that it regulates the expression of factors secreted into cerebrospinal fluid, notably transthyretin. We show that Otx2 expression impacts choroid plexus immune and stress responses, and also affects splicing which leads to changes in mRNA isoforms of proteins implicated in oxidative stress response and DNA repair. Through mass spectrometry analysis of OTX2 protein partners in the choroid plexus, and in known non-cell autonomous target regions such as visual cortex and ventricular-subventricular zone, we identified putative targets involved in cell adhesion, chromatin structure and RNA processing. Thus, OTX2 retains important roles in choroid plexus function and brain homeostasis throughout life.

Sign in / Sign up

Export Citation Format

Share Document