The p75 neurotrophin receptor has nonapoptotic antineurotrophic actions in the basal forebrain

2011 ◽  
Vol 90 (1) ◽  
pp. 278-287 ◽  
Author(s):  
Ursula Greferath ◽  
Jennifer Trieu ◽  
Graham L. Barrett
Keyword(s):  
Basal Forebrain ◽  
Neurotrophin Receptor ◽  
P75 Neurotrophin Receptor

scholarly journals The p75 neurotrophin receptor is required for the survival of neuronal progenitors and normal formation of the basal forebrain, striatum, thalamus and neocortex

Development ◽  
2019 ◽  
Vol 146 (18) ◽  
pp. dev181933 ◽  
Author(s):  
Sonja Meier ◽  
Fabienne Alfonsi ◽  
Nyoman D. Kurniawan ◽  
Michael R. Milne ◽  
Maria A. Kasherman ◽  
...  
Keyword(s):  
Basal Forebrain ◽  
Neurotrophin Receptor ◽  
P75 Neurotrophin Receptor ◽  
Neuronal Progenitors

scholarly journals Regulation of cholinergic basal forebrain development, connectivity, and function by neurotrophin receptors

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Zoran Boskovic ◽  
Sonja Meier ◽  
Yunpeng Wang ◽  
Michael R. Milne ◽  
Tessa Onraet ◽  
...  
Keyword(s):  
Basal Forebrain ◽  
Neuronal Development ◽  
Critical Role ◽  
Neurotrophin Receptor ◽  
Current Evidence ◽  
P75 Neurotrophin Receptor ◽  
Neurotrophin Receptors ◽  
Cortical Function ◽  
Cholinergic Basal Forebrain ◽  
And Function

Abstract Cholinergic basal forebrain (cBF) neurons are defined by their expression of the p75 neurotrophin receptor (p75NTR) and tropomyosin-related kinase (Trk) neurotrophin receptors in addition to cholinergic markers. It is known that the neurotrophins, particularly nerve growth factor (NGF), mediate cholinergic neuronal development and maintenance. However, the role of neurotrophin signalling in regulating adult cBF function is less clear, although in dementia, trophic signalling is reduced and p75NTR mediates neurodegeneration of cBF neurons. Here we review the current understanding of how cBF neurons are regulated by neurotrophins which activate p75NTR and TrkA, B or C to influence the critical role that these neurons play in normal cortical function, particularly higher order cognition. Specifically, we describe the current evidence that neurotrophins regulate the development of basal forebrain neurons and their role in maintaining and modifying mature basal forebrain synaptic and cortical microcircuit connectivity. Understanding the role neurotrophin signalling plays in regulating the precision of cholinergic connectivity will contribute to the understanding of normal cognitive processes and will likely provide additional ideas for designing improved therapies for the treatment of neurological disease in which cholinergic dysfunction has been demonstrated.

The Effects of P75NTR on Learning Memory Mediated by Hippocampal Apoptosis and Synaptic Plasticity

2020 ◽  
Vol 26 ◽  
Author(s):  
Jun-Jie Tang ◽  
Shuang Feng ◽  
Xing-Dong Chen ◽  
Hua Huang ◽  
Min Mao ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Learning And Memory ◽  
Neurological Diseases ◽  
Neurotrophin Receptor ◽  
P75 Neurotrophin Receptor ◽  
Negative Effects ◽  
Apoptotic Effect ◽  
New Ideas ◽  
The Relationship

: Neurological diseases bring great mental and physical torture to the patients, and have long-term and sustained negative effects on families and society. The attention to neurological diseases is increasing, and the improvement of the material level is accompanied by an increase in the demand for mental level. The p75 neurotrophin receptor (p75NTR) is a low-affinity neurotrophin receptor and involved in diverse and pleiotropic effects in the developmental and adult central nervous system (CNS). Since neurological diseases are usually accompanied by the regression of memory, the pathogenesis of p75NTR also activates and inhibits other signaling pathways, which has a serious impact on the learning and memory of patients. The results of studies shown that p75NTR is associated with LTP/LTD-induced synaptic enhancement and inhibition, suggest that p75NTR may be involved in the progression of synaptic plasticity. And its pro-apoptotic effect is associated with activation of proBDNF and inhibition of proNGF, and TrkA/p75NTR imbalance leads to pro-survival or pro-apoptotic phenomena. It can be inferred that p75NTR mediates apoptosis in the hippocampus and amygdale, which may affect learning and memory behavior. This article mainly discusses the relationship between p75NTR and learning memory and associated mechanisms, which may provide some new ideas for the treatment of neurological diseases.

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