scholarly journals In vivo knockdown of basal forebrain p75 neurotrophin receptor stimulates choline acetyltransferase activity in the mature hippocampus

2016 ◽  
Vol 94 (5) ◽  
pp. 389-400 ◽  
Author(s):  
Graham L. Barrett ◽  
Timur Naim ◽  
Jennifer Trieu ◽  
Mengjie Huang
Keyword(s):  
Choline Acetyltransferase ◽  
Basal Forebrain ◽  
Neurotrophin Receptor ◽  
P75 Neurotrophin Receptor ◽  
Acetyltransferase Activity ◽  
Choline Acetyltransferase Activity

scholarly journals Effects of Damage to the Basal Forebrain on Brain Glucose Utilization: A Reevaluation Using Positron Emission Tomography in Baboons with Extensive Unilateral Excitotoxic Lesion

1998 ◽  
Vol 18 (5) ◽  
pp. 476-490 ◽  
Author(s):  
Claude Le Mestric ◽  
Chantal Chavoix ◽  
Françoise Chapon ◽  
Florence Mézenge ◽  
Jacques Epelbaum ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Positron Emission Tomography ◽  
Choline Acetyltransferase ◽  
Basal Forebrain ◽  
Emission Tomography ◽  
Acetyltransferase Activity ◽  
Positron Emission ◽  
Cholinergic Structures ◽  
Choline Acetyltransferase Activity

Neuronal loss in the basal forebrain cholinergic structures and frontotemporal hypometabolism are two characteristics of Alzheimer's disease, but their interrelations still are unsettled. We previously reported that unilateral electrolytic lesions of the nucleus basalis of Meynert in baboons were associated with marked but transient cortical hypometabolism. The current study reevaluates this issue using improved methodology. Baboons with unilateral ibotenic acid lesion of all three basal forebrain cholinergic structures (IBO group) were compared with sham-operated animals. The CMRglc was measured with high-resolution coronal positron emission tomography scanning coregistered with magnetic resonance imaging, before surgery and serially between 4 and 72 days afterward. Severe histologic basal forebrain damage and a decrease of more than 50% in cortical choline acetyltransferase activity were found postmortem in the IBO group. Transient and nonspecific hypometabolism was found in the needle track area in both groups. Compared with the sham-operated group, only marginally significant decreases in ipsilateral–contralateral CMRglc ratios were observed in the IBO group, affecting only 1 of 14 neocortical areas investigated (the anterior temporal cortex) at a single postsurgical time (day 14), and the posterior hippocampal region at days 14 and 38. Furthermore, there was no consistently significant correlation between ipsilateral–contralateral CMRglc ratios and cortical choline acetyltransferase activity values in any of the four regions analyzed. These results suggest that cholinergic deafferentation play at best a marginal role in the brain hypometabolism observed in Alzheimer's disease.

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