Role of p75 neurotrophin receptor in normal cholinergic basal forebrain function in adults

2016 ◽  
Author(s):  
Zoran Boskovic
Keyword(s):  
Basal Forebrain ◽  
Neurotrophin Receptor ◽  
P75 Neurotrophin Receptor ◽  
Cholinergic Basal Forebrain

scholarly journals Regulation of cholinergic basal forebrain development, connectivity, and function by neurotrophin receptors

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Zoran Boskovic ◽  
Sonja Meier ◽  
Yunpeng Wang ◽  
Michael R. Milne ◽  
Tessa Onraet ◽  
...  
Keyword(s):  
Basal Forebrain ◽  
Neuronal Development ◽  
Critical Role ◽  
Neurotrophin Receptor ◽  
Current Evidence ◽  
P75 Neurotrophin Receptor ◽  
Neurotrophin Receptors ◽  
Cortical Function ◽  
Cholinergic Basal Forebrain ◽  
And Function

Abstract Cholinergic basal forebrain (cBF) neurons are defined by their expression of the p75 neurotrophin receptor (p75NTR) and tropomyosin-related kinase (Trk) neurotrophin receptors in addition to cholinergic markers. It is known that the neurotrophins, particularly nerve growth factor (NGF), mediate cholinergic neuronal development and maintenance. However, the role of neurotrophin signalling in regulating adult cBF function is less clear, although in dementia, trophic signalling is reduced and p75NTR mediates neurodegeneration of cBF neurons. Here we review the current understanding of how cBF neurons are regulated by neurotrophins which activate p75NTR and TrkA, B or C to influence the critical role that these neurons play in normal cortical function, particularly higher order cognition. Specifically, we describe the current evidence that neurotrophins regulate the development of basal forebrain neurons and their role in maintaining and modifying mature basal forebrain synaptic and cortical microcircuit connectivity. Understanding the role neurotrophin signalling plays in regulating the precision of cholinergic connectivity will contribute to the understanding of normal cognitive processes and will likely provide additional ideas for designing improved therapies for the treatment of neurological disease in which cholinergic dysfunction has been demonstrated.

scholarly journals Role of p75NTR in female rat urinary bladder with cyclophosphamide-induced cystitis

2008 ◽  
Vol 295 (6) ◽  
pp. F1778-F1789 ◽  
Author(s):  
Mary Beth Klinger ◽  
Margaret A. Vizzard
Keyword(s):  
Urinary Bladder ◽  
Intravesical Instillation ◽  
Bladder Function ◽  
Neurotrophin Receptor ◽  
P75 Neurotrophin Receptor ◽  
Female Rat ◽  
Rat Urinary Bladder ◽  
Micturition Reflex ◽  
Reflex Pathways

Previous studies demonstrated changes in urinary bladder neurotrophin content and upregulation of neurotrophin receptors, TrkA and the p75 neurotrophin receptor (p75NTR), in micturition reflex pathways after cyclophosphamide (CYP)-induced cystitis. p75NTR can bind nerve growth factor (NGF) and modulate NGF-TrkA binding and signaling. We examined p75NTR expression and the role of p75NTR in the micturition reflex in control and CYP-treated rats. p75NTR Immunoreactivity was present throughout the urinary bladder. CYP-induced cystitis (4 h, 48 h, chronic) increased ( P ≤ 0.05) p75NTR expression in whole urinary bladder as shown by Western blotting. The role of p75NTR in bladder function in control and CYP-treated rats was determined using conscious cystometry and immunoneutralization or PD90780, a compound known to specifically block NGF binding to p75NTR. An anti-p75NTR monoclonal antibody or PD90780 was infused intravesically and cystometric parameters were evaluated. Both methods of p75NTR blockade significantly ( P ≤ 0.05) decreased the intercontraction interval and void volume in control and CYP-treated rats. Intravesical infusion of PD90780 also significantly ( P ≤ 0.001) increased intravesical pressure and increased the number of nonvoiding contractions during the filling phase. Control intravesical infusions of isotype-matched IgG and vehicle were without effect. Intravesical instillation of PD90780 significantly ( P ≤ 0.01) reduced the volume threshold to elicit a micturition contraction in control rats (no inflammation) and CYP-treated in a closed urinary bladder system. These studies demonstrate 1) ubiquitous p75NTR expression in urinary bladder and increased expression with CYP-induced cystitis and 2) p75NTR blockade at the level of the urinary bladder produces bladder hyperreflexia in control and CYP-treated rats. The overall activity of the urinary bladder reflects the balance of NGF-p75NTR and NGF-TrkA signaling.

scholarly journals The p75 neurotrophin receptor is required for the survival of neuronal progenitors and normal formation of the basal forebrain, striatum, thalamus and neocortex

Development ◽  
2019 ◽  
Vol 146 (18) ◽  
pp. dev181933 ◽  
Author(s):  
Sonja Meier ◽  
Fabienne Alfonsi ◽  
Nyoman D. Kurniawan ◽  
Michael R. Milne ◽  
Maria A. Kasherman ◽  
...  
Keyword(s):  
Basal Forebrain ◽  
Neurotrophin Receptor ◽  
P75 Neurotrophin Receptor ◽  
Neuronal Progenitors

scholarly journals The role of cholinergic basal forebrain neurons in adenosine-mediated homeostatic control of sleep: Lessons from 192 IgG–saporin lesions

Neuroscience ◽  
2008 ◽  
Vol 157 (1) ◽  
pp. 238-253 ◽  
Author(s):  
A.V. Kalinchuk ◽  
R.W. McCarley ◽  
D. Stenberg ◽  
T. Porkka-Heiskanen ◽  
R. Basheer
Keyword(s):  
Basal Forebrain ◽  
Homeostatic Control ◽  
Cholinergic Basal Forebrain ◽  
Forebrain Neurons
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