Comparative magnitude and kinetics of human cytomegalovirus-specific CD4+ and CD8+ T-cell responses in pregnant women with primary versus remote infection and in transmitting versus non-transmitting mothers: Its utility for dating primary infection in pre

2016 ◽  
Vol 88 (7) ◽  
pp. 1238-1246 ◽  
Author(s):  
Chiara Fornara ◽  
Milena Furione ◽  
Alessia Arossa ◽  
Giuseppe Gerna ◽  
Daniele Lilleri
Keyword(s):  
T Cell ◽  
Pregnant Women ◽  
Human Cytomegalovirus ◽  
Primary Infection ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses ◽  
Remote Infection ◽  
Kinetics Of

Human cytomegalovirus-specific CD4+ and CD8+ T cell responses in primary infection of the immunocompetent and the immunocompromised host

2009 ◽  
Vol 131 (3) ◽  
pp. 395-403 ◽  
Author(s):  
Daniele Lilleri ◽  
Paola Zelini ◽  
Chiara Fornara ◽  
Giuditta Comolli ◽  
Maria Grazia Revello ◽  
...  
Keyword(s):  
T Cell ◽  
Human Cytomegalovirus ◽  
Primary Infection ◽  
T Cell Responses ◽  
Immunocompromised Host ◽  
Cd8 T Cell ◽  
Cell Responses

scholarly journals DNA Immunization Using Highly Conserved Murine Cytomegalovirus Genes Encoding Homologs of Human Cytomegalovirus UL54 (DNA Polymerase) and UL105 (Helicase) Elicits Strong CD8 T-Cell Responses and Is Protective against Systemic Challenge

2007 ◽  
Vol 81 (14) ◽  
pp. 7766-7775 ◽  
Author(s):  
Christopher S. Morello ◽  
Laura A. Kelley ◽  
Michael W. Munks ◽  
Ann B. Hill ◽  
Deborah H. Spector
Keyword(s):  
T Cells ◽  
T Cell ◽  
Dna Polymerase ◽  
Human Cytomegalovirus ◽  
Cd8 T Cells ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Murine Cytomegalovirus ◽  
Dna Immunization ◽  
Cell Responses

ABSTRACT Human cytomegalovirus (HCMV) establishes a lifelong infection with the potential for reinfection or viral transmission even in the presence of strong and diverse CD8 T-lymphocyte responses. This suggests that the CMVs skew the host T-cell response in order to favor viral persistence. In this study, we hypothesized that the essential, nonstructural proteins that are highly conserved among the CMVs may represent a novel class of T-cell targets for vaccine-mediated protection due to their requirements for expression and sequence stability, but that the observed subdominance of these antigens in the CMV-infected host results from the virus limiting the T-cell responses to otherwise-protective specificities. We found that DNA immunization of mice with the murine CMV (MCMV) homologs of HCMV DNA polymerase (M54) or helicase (M105) was protective against virus replication in the spleen following systemic challenge, with the protection level elicited by the M54 DNA being comparable to that of DNA expressing the immunodominant IE1 (pp89). Intracellular gamma interferon staining of CD8 T cells from mice immunized with either the M54 or M105 DNAs showed strong primary responses that recalled rapidly after viral challenge. M54- and M105-specific CD8 T cells were detected after the primary MCMV infection, but their levels were not consistently above the background level. The conserved, essential proteins of the CMVs thus represent a novel class of CD8 T-cell targets that may contribute to a successful HCMV vaccine strategy.

scholarly journals Distinct Kinetics of Gag-Specific CD4+ and CD8+ T Cell Responses during Acute HIV-1 Infection

2012 ◽  
Vol 188 (5) ◽  
pp. 2198-2206 ◽  
Author(s):  
Catherine Riou ◽  
Vitaly V. Ganusov ◽  
Suzanne Campion ◽  
Mandla Mlotshwa ◽  
Michael K. P. Liu ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses ◽  
Acute Hiv ◽  
Kinetics Of ◽  
Hiv 1

scholarly journals Human cytomegalovirus microRNA miR-US4-1 inhibits CD8+ T cell responses by targeting the aminopeptidase ERAP1

2011 ◽  
Vol 12 (10) ◽  
pp. 984-991 ◽  
Author(s):  
Sungchul Kim ◽  
Sanghyun Lee ◽  
Jinwook Shin ◽  
Youngkyun Kim ◽  
Irini Evnouchidou ◽  
...  
Keyword(s):  
T Cell ◽  
Human Cytomegalovirus ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses

Ex vivo monitoring of human cytomegalovirus-specific CD8+ T-cell responses using QuantiFERON�-CMV

2007 ◽  
Vol 9 (2) ◽  
pp. 165-170 ◽  
Author(s):  
S. Walker ◽  
C. Fazou ◽  
T. Crough ◽  
R. Holdsworth ◽  
P. Kiely ◽  
...  
Keyword(s):  
T Cell ◽  
Human Cytomegalovirus ◽  
Ex Vivo ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses

scholarly journals Differential Kinetics of Antigen-Specific CD4+and CD8+T Cell Responses in the Regression of Retrovirus-Induced Sarcomas

2002 ◽  
Vol 169 (6) ◽  
pp. 3191-3199 ◽  
Author(s):  
Koen Schepers ◽  
Mireille Toebes ◽  
Gitte Sotthewes ◽  
Florry A. Vyth-Dreese ◽  
Trees A. M. Dellemijn ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses ◽  
Kinetics Of
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