Gender, age-related, and regional differences of the magnetization transfer ratio of the cortical and subcortical brain gray matter

2014 ◽  
Vol 40 (2) ◽  
pp. spcone-spcone
Author(s):  
Mario Mascalchi ◽  
Nicola Toschi ◽  
Andrea Ginestroni ◽  
Marco Giannelli ◽  
Emanuele Nicolai ◽  
...  
2013 ◽  
Vol 40 (2) ◽  
pp. 360-366 ◽  
Author(s):  
Mario Mascalchi ◽  
Nicola Toschi ◽  
Andrea Ginestroni ◽  
Marco Giannelli ◽  
Emanuele Nicolai ◽  
...  

2008 ◽  
Vol 65 (11) ◽  
pp. 1454 ◽  
Author(s):  
Zhaleh Khaleeli ◽  
Daniel R. Altmann ◽  
Mara Cercignani ◽  
Olga Ciccarelli ◽  
David H. Miller ◽  
...  

2019 ◽  
Vol 26 (3) ◽  
pp. 322-332 ◽  
Author(s):  
Dejan Jakimovski ◽  
Murali Ramanathan ◽  
Bianca Weinstock-Guttman ◽  
Niels Bergsland ◽  
Deepa P Ramasamay ◽  
...  

Background: Epstein–Barr virus (EBV) infection has been associated with higher clinical activity and risk of multiple sclerosis (MS). Objective: To evaluate associations between EBV-specific humoral response and magnetization transfer ratio (MTR)-derived measure in MS patients and healthy controls (HCs). Methods: The study included 101 MS patients (69 relapsing-remitting multiple sclerosis (RRMS) and 32 secondary-progressive multiple sclerosis (SPMS)) and 41 HCs who underwent clinical, serological, and magnetic resonance imaging (MRI) investigations. MTR values of T1 or T2 lesion volume (LV), normal-appearing (NA) brain tissue (NABT), gray matter (NAGM), and white matter (NAWM) were obtained. Enzyme-linked immunosorbent assay was used to quantify EBV antibody levels. Partial correlations corrected for MRI strength were used, and Benjamini–Hochberg–adjusted p-values < 0.05 were considered significant. Results: MS patients had significantly higher anti-EBV nuclear antigen-1 (EBNA-1) titer when compared to HCs (107.9 U/mL vs 27.8 U/mL, p < 0.001). Within the MS group, higher serum anti-EBNA-1 titer was significantly correlated with lower T1-LV MTR ( r = –0.287, p = 0.035). Within the RRMS group, higher serum anti-EBNA-1 titer was associated with T1-LV MTR ( r = –0.524, p = 0.001) and NAGM MTR ( r = –0.308, p = 0.043). These associations were not present in HCs or SPMS patients. Conclusion: Greater EBV humoral response is associated with lower GM MTR changes and focal destructive lesion pathology in RRMS patients.


Radiology ◽  
2012 ◽  
Vol 263 (2) ◽  
pp. 510-517 ◽  
Author(s):  
Revital Nossin-Manor ◽  
Andrew D. Chung ◽  
Hilary E. A. Whyte ◽  
Manohar M. Shroff ◽  
Margot J. Taylor ◽  
...  

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e84162 ◽  
Author(s):  
Sveinung Fjær ◽  
Lars Bø ◽  
Arvid Lundervold ◽  
Kjell-Morten Myhr ◽  
Tina Pavlin ◽  
...  

2005 ◽  
Vol 16 (1) ◽  
pp. 215-220 ◽  
Author(s):  
Vassilios Xydis ◽  
Loukas Astrakas ◽  
Anastasia Zikou ◽  
Kostandina Pantou ◽  
Styliani Andronikou ◽  
...  

NeuroImage ◽  
2010 ◽  
Vol 49 (4) ◽  
pp. 3015-3026 ◽  
Author(s):  
Steffen Volz ◽  
Ulrike Nöth ◽  
Anna Rotarska-Jagiela ◽  
Ralf Deichmann

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