Deep Gray Matter Maturation in Very Preterm Neonates: Regional Variations and Pathology-related Age-dependent Changes in Magnetization Transfer Ratio

Radiology ◽  
2012 ◽  
Vol 263 (2) ◽  
pp. 510-517 ◽  
Author(s):  
Revital Nossin-Manor ◽  
Andrew D. Chung ◽  
Hilary E. A. Whyte ◽  
Manohar M. Shroff ◽  
Margot J. Taylor ◽  
...  
Keyword(s):  
Gray Matter ◽  
Magnetization Transfer ◽  
Preterm Neonates ◽  
Magnetization Transfer Ratio ◽  
Regional Variations ◽  
Transfer Ratio ◽  
Very Preterm ◽  
Age Dependent ◽  
Deep Gray Matter

scholarly journals Deep Gray Matter Demyelination Detected by Magnetization Transfer Ratio in the Cuprizone Model

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e84162 ◽  
Author(s):  
Sveinung Fjær ◽  
Lars Bø ◽  
Arvid Lundervold ◽  
Kjell-Morten Myhr ◽  
Tina Pavlin ◽  
...  
Keyword(s):  
Gray Matter ◽  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
Transfer Ratio ◽  
Deep Gray Matter

scholarly journals Magnetization Transfer Ratio in Gray Matter

2008 ◽  
Vol 65 (11) ◽  
pp. 1454 ◽  
Author(s):  
Zhaleh Khaleeli ◽  
Daniel R. Altmann ◽  
Mara Cercignani ◽  
Olga Ciccarelli ◽  
David H. Miller ◽  
...  
Keyword(s):  
Gray Matter ◽  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
Transfer Ratio

Gender, age-related, and regional differences of the magnetization transfer ratio of the cortical and subcortical brain gray matter

2014 ◽  
Vol 40 (2) ◽  
pp. spcone-spcone
Author(s):  
Mario Mascalchi ◽  
Nicola Toschi ◽  
Andrea Ginestroni ◽  
Marco Giannelli ◽  
Emanuele Nicolai ◽  
...  
Keyword(s):  
Gray Matter ◽  
Regional Differences ◽  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
Transfer Ratio ◽  
Subcortical Brain ◽  
Age Related

scholarly journals Higher EBV response is associated with more severe gray matter and lesion pathology in relapsing multiple sclerosis patients: A case-controlled magnetization transfer ratio study

2019 ◽  
Vol 26 (3) ◽  
pp. 322-332 ◽  
Author(s):  
Dejan Jakimovski ◽  
Murali Ramanathan ◽  
Bianca Weinstock-Guttman ◽  
Niels Bergsland ◽  
Deepa P Ramasamay ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Magnetization Transfer ◽  
Humoral Response ◽  
Nuclear Antigen ◽  
Enzyme Linked Immunosorbent Assay ◽  
Magnetization Transfer Ratio ◽  
Lesion Volume ◽  
Transfer Ratio ◽  
Multiple Sclerosis Patients

Background: Epstein–Barr virus (EBV) infection has been associated with higher clinical activity and risk of multiple sclerosis (MS). Objective: To evaluate associations between EBV-specific humoral response and magnetization transfer ratio (MTR)-derived measure in MS patients and healthy controls (HCs). Methods: The study included 101 MS patients (69 relapsing-remitting multiple sclerosis (RRMS) and 32 secondary-progressive multiple sclerosis (SPMS)) and 41 HCs who underwent clinical, serological, and magnetic resonance imaging (MRI) investigations. MTR values of T1 or T2 lesion volume (LV), normal-appearing (NA) brain tissue (NABT), gray matter (NAGM), and white matter (NAWM) were obtained. Enzyme-linked immunosorbent assay was used to quantify EBV antibody levels. Partial correlations corrected for MRI strength were used, and Benjamini–Hochberg–adjusted p-values < 0.05 were considered significant. Results: MS patients had significantly higher anti-EBV nuclear antigen-1 (EBNA-1) titer when compared to HCs (107.9 U/mL vs 27.8 U/mL, p < 0.001). Within the MS group, higher serum anti-EBNA-1 titer was significantly correlated with lower T1-LV MTR ( r = –0.287, p = 0.035). Within the RRMS group, higher serum anti-EBNA-1 titer was associated with T1-LV MTR ( r = –0.524, p = 0.001) and NAGM MTR ( r = –0.308, p = 0.043). These associations were not present in HCs or SPMS patients. Conclusion: Greater EBV humoral response is associated with lower GM MTR changes and focal destructive lesion pathology in RRMS patients.

Gender, age-related, and regional differences of the magnetization transfer ratio of the cortical and subcortical brain gray matter

2013 ◽  
Vol 40 (2) ◽  
pp. 360-366 ◽  
Author(s):  
Mario Mascalchi ◽  
Nicola Toschi ◽  
Andrea Ginestroni ◽  
Marco Giannelli ◽  
Emanuele Nicolai ◽  
...  
Keyword(s):  
Gray Matter ◽  
Regional Differences ◽  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
Transfer Ratio ◽  
Subcortical Brain ◽  
Age Related

A fast B1-mapping method for the correction and normalization of magnetization transfer ratio maps at 3 T

NeuroImage ◽  
2010 ◽  
Vol 49 (4) ◽  
pp. 3015-3026 ◽  
Author(s):  
Steffen Volz ◽  
Ulrike Nöth ◽  
Anna Rotarska-Jagiela ◽  
Ralf Deichmann
Keyword(s):  
Magnetization Transfer ◽  
Mapping Method ◽  
Magnetization Transfer Ratio ◽  
Transfer Ratio ◽  
B1 Mapping

Cervical cord magnetization transfer ratio and clinical changes over 18 months in patients with relapsing-remitting multiple sclerosis: a preliminary study

2006 ◽  
Vol 12 (5) ◽  
pp. 662-665 ◽  
Author(s):  
A Charil ◽  
D Caputo ◽  
R Cavarretta ◽  
M P Sormani ◽  
P Ferrante ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Relapse Rate ◽  
Magnetization Transfer ◽  
Small Sample ◽  
Cervical Cord ◽  
Magnetization Transfer Ratio ◽  
Short Term ◽  
Disease Evolution ◽  
Transfer Ratio ◽  
Relapsing Remitting

Background Magnetization transfer ratio (MTR) permits the quantitative estimation of cervical cord tissue damage in patients with multiple sclerosis (MS). Objective To determine whether a single time-point MTR scan of the cervical cord is associated with short-term disease evolution in patients with relapsing-remitting (RR) MS. Methods Using a 1.5-T magnetic resonance imaging (MRI) system with a tailored cervical cord phased array coil, fast short-tau inversion recovery (fast-STIR) and MTR scans were obtained from 14 untreated patients with RRMS at baseline. Cervical cord MTR histograms were derived. Over the 18- month follow-up period, relapse rate was measured and disability assessed by the Expanded Disability Status Scale (EDSS) score. Results Average cervical cord MTR was correlated with relapse rate ( r= -0.56, P = 0.037). A moderate correlation ( r values ranging from -0.33 to -0.36) between baseline cervical cord MTR metrics and EDSS changes over 18 months was also noted, albeit statistical significance was not reached ( P = 0.26 and 0.21, respectively) perhaps because of the relatively small sample size. Conclusions This study suggests that a ‘snapshot’ MT MRI assessment of the cervical cord may detect cervical cord tissue changes associated with short-term disease evolution in RRMS.

Measurement of magnetization transfer ratio (MTR) from cervical spinal cord: Multicenter reproducibility and variability

2018 ◽  
Vol 49 (6) ◽  
pp. 1777-1785 ◽  
Author(s):  
Benoit Combès ◽  
Laureline Monteau ◽  
Elise Bannier ◽  
Virginie Callot ◽  
Pierre Labauge ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cervical Spinal Cord ◽  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
Transfer Ratio
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