scholarly journals Alterations in brain white matter contributing to age-related slowing of task switching performance: The role of radial diffusivity and magnetization transfer ratio

2016 ◽  
Vol 37 (11) ◽  
pp. 4084-4098 ◽  
Author(s):  
Leen Serbruyns ◽  
Inge Leunissen ◽  
Peter van Ruitenbeek ◽  
Lisa Pauwels ◽  
Karen Caeyenberghs ◽  
...  
Keyword(s):  
White Matter ◽  
Task Switching ◽  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
Radial Diffusivity ◽  
Transfer Ratio ◽  
Switching Performance ◽  
Brain White Matter ◽  
Age Related

scholarly journals The role of white matter microstructure in age-related deficits in task-switching

2013 ◽  
Vol 7 ◽  
Author(s):  
Jolly Todd ◽  
Michie Pat ◽  
Fulham William ◽  
Cooper Patrick ◽  
Levi Christopher ◽  
...  
Keyword(s):  
White Matter ◽  
Task Switching ◽  
Age Related ◽  
White Matter Microstructure

Characterization of white matter damage in animal models of multiple sclerosis by magnetization transfer ratio and quantitative mapping of the apparent bound proton fraction f*

2009 ◽  
Vol 15 (1) ◽  
pp. 16-27 ◽  
Author(s):  
M Rausch ◽  
PS Tofts ◽  
P Lervik ◽  
AR Walmsley ◽  
A Mir ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Animal Models ◽  
Tissue Damage ◽  
Magnetization Transfer ◽  
Transverse Relaxation Time ◽  
Magnetization Transfer Ratio ◽  
White Matter Damage ◽  
Transfer Ratio ◽  
Quantitative Mapping

Quantitative magnetization transfer magnetic resonance imaging (qMT-MRI) can be used to improve detection of white matter tissue damage in multiple sclerosis (MS) and animal models thereof. To study the correlation between MT parameters and tissue damage, the magnetization transfer ratio (MTR), the parameter f* (closely related to the bound proton fraction) and the bound proton transverse relaxation time T2B of lesions in a model of focal experimental autoimmune encephalomyelitis (EAE) were measured on a 7T animal scanner and data were compared with histological markers indicative for demyelination, axonal density, and tissue damage. A clear spatial correspondence was observed between reduced values of MTR and demyelination in this animal model. We observed two different levels of MTR and f* reduction for these lesions. One was characterized by a pronounced demyelination and the other corresponded to a more severe loss of the cellular matrix. Changes in f* were generally more pronounced than those of MTR in areas of demyelination. Moreover, a reduction of f* was already observed for tissue where MTR was virtually normal. No changes in T2B were observed for the lesions. We conclude that MTR and qMT mapping are efficient and reliable readouts for studying demyelination in animal models of MS, and that the analysis of regional f* might be even superior to the analysis of MTR values. Therefore, quantitative mapping of f* from human brains might also improve the detection of white matter damage in MS.

Surface-in pathology in multiple sclerosis: a new view on pathogenesis?

Brain ◽  
2021 ◽  
Author(s):  
Matteo Pardini ◽  
J William L Brown ◽  
Roberta Magliozzi ◽  
Richard Reynolds ◽  
Declan T Chard
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Grey Matter ◽  
Magnetization Transfer ◽  
Neuronal Loss ◽  
Magnetization Transfer Ratio ◽  
Supporting Evidence ◽  
Transfer Ratio ◽  
Meningeal Inflammation

Abstract While multiple sclerosis can affect any part of the CNS, it does not do so evenly. In white matter it has long been recognized that lesions tend to occur around the ventricles, and grey matter lesions mainly accrue in the outermost (subpial) cortex. In cortical grey matter, neuronal loss is greater in the outermost layers. This cortical gradient has been replicated in vivo with magnetization transfer ratio and similar gradients in grey and white matter magnetization transfer ratio are seen around the ventricles, with the most severe abnormalities abutting the ventricular surface. The cause of these gradients remains uncertain, though soluble factors released from meningeal inflammation into the CSF has the most supporting evidence. In this Update, we review this ‘surface-in’ spatial distribution of multiple sclerosis abnormalities and consider the implications for understanding pathogenic mechanisms and treatments designed to slow or stop them.

scholarly journals Magnetization transfer ratio measures in normal-appearing white matter show periventricular gradient abnormalities in multiple sclerosis

Brain ◽  
2015 ◽  
Vol 138 (5) ◽  
pp. 1239-1246 ◽  
Author(s):  
Zheng Liu ◽  
Matteo Pardini ◽  
Özgür Yaldizli ◽  
Varun Sethi ◽  
Nils Muhlert ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
Transfer Ratio ◽  
Normal Appearing White Matter

Gender, age-related, and regional differences of the magnetization transfer ratio of the cortical and subcortical brain gray matter

2014 ◽  
Vol 40 (2) ◽  
pp. spcone-spcone
Author(s):  
Mario Mascalchi ◽  
Nicola Toschi ◽  
Andrea Ginestroni ◽  
Marco Giannelli ◽  
Emanuele Nicolai ◽  
...  
Keyword(s):  
Gray Matter ◽  
Regional Differences ◽  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
Transfer Ratio ◽  
Subcortical Brain ◽  
Age Related

scholarly journals A multicenter measurement of magnetization transfer ratio in normal white matter

1999 ◽  
Vol 9 (3) ◽  
pp. 441-446 ◽  
Author(s):  
Isabelle Berry ◽  
Gareth J. Barker ◽  
Frederik Barkhof ◽  
Adriana Campi ◽  
Vincent Dousset ◽  
...  
Keyword(s):  
White Matter ◽  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
Transfer Ratio ◽  
Normal White Matter

scholarly journals Microstructural white matter changes preceding white matter hyperintensities in migraine

Neurology ◽  
2019 ◽  
Vol 93 (7) ◽  
pp. e688-e694 ◽  
Author(s):  
Enrico B. Arkink ◽  
Inge H. Palm-Meinders ◽  
Hille Koppen ◽  
Julien Milles ◽  
Baldur van Lew ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
White Matter Changes ◽  
Whole Brain ◽  
Microstructural Changes ◽  
Tissue Integrity ◽  
Brain White Matter

ObjectiveWe used magnetization transfer imaging to assess white matter tissue integrity in migraine, to explore whether white matter microstructure was more diffusely affected beyond visible white matter hyperintensities (WMHs), and to explore whether focal invisible microstructural changes precede visible focal WMHs in migraineurs.MethodsWe included 137 migraineurs (79 with aura, 58 without aura) and 74 controls from the Cerebral Abnormalities in Migraine, an Epidemiological Risk Analysis (CAMERA) study, a longitudinal population-based study on structural brain lesions in migraine patients, who were scanned at baseline and at a 9-year follow-up. To assess microstructural brain tissue integrity, baseline magnetization transfer ratio (MTR) values were calculated for whole brain white matter. Baseline MTR values were determined for areas of normal-appearing white matter (NAWM) that had progressed into MRI-detectable WMHs at follow-up and compared to MTR values of contralateral NAWM.ResultsMTR values for whole brain white matter did not differ between migraineurs and controls. In migraineurs, but not in controls, NAWM that later progressed to WMHs at follow-up had lower mean MTR (mean [SD] 0.354 [0.009] vs 0.356 [0.008], p = 0.047) at baseline as compared to contralateral white matter.ConclusionsWe did not find evidence for widespread microstructural white matter changes in migraineurs compared to controls. However, our findings suggest that a gradual or stepwise process might be responsible for evolution of focal invisible microstructural changes into focal migraine-related visible WMHs.

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