scholarly journals In vivo chemical exchange saturation transfer imaging of creatine (CrCEST) in skeletal muscle at 3T

2013 ◽  
Vol 40 (3) ◽  
pp. 596-602 ◽  
Author(s):  
Feliks Kogan ◽  
Mohammad Haris ◽  
Catherine Debrosse ◽  
Anup Singh ◽  
Ravi P. Nanga ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer

scholarly journals Novel nanomedicine with a chemical-exchange saturation transfer effect for breast cancer treatment in vivo

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Yanlong Jia ◽  
Chaochao Wang ◽  
Jiehua Zheng ◽  
Guisen Lin ◽  
Dalong Ni ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Chemical Exchange ◽  
Raft Polymerization ◽  
Animal Experiments ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Cest Imaging

Abstract Background Nanomedicine is a promising new approach to cancer treatment that avoids the disadvantages of traditional chemotherapy and improves therapeutic indices. However, the lack of a real-time visualization imaging technology to monitor drug distribution greatly limits its clinical application. Image-tracked drug delivery is of great clinical interest; it is useful for identifying those patients for whom the therapy is more likely to be beneficial. This paper discusses a novel nanomedicine that displays features of nanoparticles and facilitates functional magnetic resonance imaging but is challenging to prepare. Results To achieve this goal, we synthesized an acylamino-containing amphiphilic block copolymer (polyethylene glycol-polyacrylamide-polyacetonitrile, PEG-b-P(AM-co-AN)) by reversible addition-fragmentation chain transfer (RAFT) polymerization. The PEG-b-P(AM-co-AN) has chemical exchange saturation transfer (CEST) effects, which enable the use of CEST imaging for monitoring nanocarrier accumulation and providing molecular information of pathological tissues. Based on PEG-b-P(AM-co-AN), a new nanomedicine PEG-PAM-PAN@DOX was constructed by nano-precipitation. The self-assembling nature of PEG-PAM-PAN@DOX made the synthesis effective, straightforward, and biocompatible. In vitro studies demonstrate decreased cytotoxicity of PEG-PAM-PAN@DOX compared to free doxorubicin (half-maximal inhibitory concentration (IC50), mean ~ 0.62 μg/mL vs. ~ 5 μg/mL), and the nanomedicine more efficiently entered the cytoplasm and nucleus of cancer cells to kill them. Further, in vivo animal experiments showed that the nanomedicine developed was not only effective against breast cancer, but also displayed an excellent sensitive CEST effect for monitoring drug accumulation (at about 0.5 ppm) in tumor areas. The CEST signal of post-injection 2 h was significantly higher than that of pre-injection (2.17 ± 0.88% vs. 0. 09 ± 0.75%, p < 0.01). Conclusions The nanomedicine with CEST imaging reflects the characterization of tumors and therapeutic functions has great potential medical applications.

scholarly journals Method for high-resolution imaging of creatine in vivo using chemical exchange saturation transfer

2013 ◽  
Vol 71 (1) ◽  
pp. 164-172 ◽  
Author(s):  
Feliks Kogan ◽  
Mohammad Haris ◽  
Anup Singh ◽  
Kejia Cai ◽  
Catherine Debrosse ◽  
...  
Keyword(s):  
High Resolution ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
High Resolution Imaging ◽  
Saturation Transfer ◽  
Resolution Imaging

Mouse skeletal muscle creatine chemical exchange saturation transfer (CrCEST) imaging at 11.7T MRI

2019 ◽  
Vol 51 (2) ◽  
pp. 563-570 ◽  
Author(s):  
Yusuke Takahashi ◽  
Shigeyoshi Saito ◽  
Hidetaka Kioka ◽  
Rikita Araki ◽  
Yoshihiro Asano ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Mouse Skeletal Muscle ◽  
Muscle Creatine

scholarly journals pH Mapping of Skeletal Muscle by Chemical Exchange Saturation Transfer (CEST) Imaging

Cells ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 2610
Author(s):  
Yu-Wen Chen ◽  
Hong-Qing Liu ◽  
Qi-Xuan Wu ◽  
Yu-Han Huang ◽  
Yu-Ying Tung ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Electrical Stimulation ◽  
Magnetic Resonance ◽  
Ph Value ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Resonance Spectroscopy ◽  
Saturation Transfer ◽  
Ph Changes ◽  
Cest Imaging

Magnetic resonance imaging (MRI) is extensively used in clinical and basic biomedical research. However, MRI detection of pH changes still poses a technical challenge. Chemical exchange saturation transfer (CEST) imaging is a possible solution to this problem. Using saturation transfer, alterations in the exchange rates between the solute and water protons because of small pH changes can be detected with greater sensitivity. In this study, we examined a fatigued skeletal muscle model in electrically stimulated mice. The measured CEST signal ratio was between 1.96 ppm and 2.6 ppm in the z-spectrum, and this was associated with pH values based on the ratio between the creatine (Cr) and the phosphocreatine (PCr). The CEST results demonstrated a significant contrast change at the electrical stimulation site. Moreover, the pH value was observed to decrease from 7.23 to 7.15 within 20 h after electrical stimulation. This pH decrease was verified by 31P magnetic resonance spectroscopy and behavioral tests, which showed a consistent variation over time.

scholarly journals In vivo multicolor molecular MR imaging using diamagnetic chemical exchange saturation transfer liposomes

2011 ◽  
Vol 67 (4) ◽  
pp. 1106-1113 ◽  
Author(s):  
Guanshu Liu ◽  
Matthew Moake ◽  
Yah-el Har-el ◽  
Chris M. Long ◽  
Kannie W.Y. Chan ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer

In Vivo Mapping and Quantification of Creatine Using Chemical Exchange Saturation Transfer Imaging in Rat Models of Epileptic Seizure

2018 ◽  
Vol 21 (2) ◽  
pp. 232-239 ◽  
Author(s):  
Dong-Hoon Lee ◽  
Do-Wan Lee ◽  
Jae-Im Kwon ◽  
Chul-Woong Woo ◽  
Sang-Tae Kim ◽  
...  
Keyword(s):  
Epileptic Seizure ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Rat Models

Progress toward quantitative in vivo chemical exchange saturation transfer (CEST) MRI

2017 ◽  
Vol 57 (9) ◽  
pp. 809-824 ◽  
Author(s):  
Yang Ji ◽  
Iris Yuwen Zhou ◽  
Bensheng Qiu ◽  
Phillip Zhe Sun
Keyword(s):  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Cest Mri
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