scholarly journals In vitro and in vivo comparison of MRI chemical exchange saturation transfer (CEST) properties between native glucose and 3‐O‐Methyl‐D‐glucose in a murine tumor model

2021 ◽  
Author(s):  
Annasofia Anemone ◽  
Martina Capozza ◽  
Francesca Arena ◽  
Sara Zullino ◽  
Paola Bardini ◽  
...  
Keyword(s):  
Chemical Exchange ◽  
Tumor Model ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Murine Tumor ◽  
Murine Tumor Model

scholarly journals A Cu(ii) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights

2017 ◽  
Vol 53 (1) ◽  
pp. 134-137 ◽  
Author(s):  
D. Montagner ◽  
B. Fresch ◽  
K. Browne ◽  
V. Gandin ◽  
A. Erxleben
Keyword(s):  
Tumor Model ◽  
Translocator Protein ◽  
Tumor Mass ◽  
Cu Complex ◽  
Murine Tumor ◽  
Murine Tumor Model ◽  
Antitumor Potential

A Cu complex targeting the translocator protein induces a 98% reduction of tumor mass in a murine tumor model.

scholarly journals Novel nanomedicine with a chemical-exchange saturation transfer effect for breast cancer treatment in vivo

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Yanlong Jia ◽  
Chaochao Wang ◽  
Jiehua Zheng ◽  
Guisen Lin ◽  
Dalong Ni ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Chemical Exchange ◽  
Raft Polymerization ◽  
Animal Experiments ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Cest Imaging

Abstract Background Nanomedicine is a promising new approach to cancer treatment that avoids the disadvantages of traditional chemotherapy and improves therapeutic indices. However, the lack of a real-time visualization imaging technology to monitor drug distribution greatly limits its clinical application. Image-tracked drug delivery is of great clinical interest; it is useful for identifying those patients for whom the therapy is more likely to be beneficial. This paper discusses a novel nanomedicine that displays features of nanoparticles and facilitates functional magnetic resonance imaging but is challenging to prepare. Results To achieve this goal, we synthesized an acylamino-containing amphiphilic block copolymer (polyethylene glycol-polyacrylamide-polyacetonitrile, PEG-b-P(AM-co-AN)) by reversible addition-fragmentation chain transfer (RAFT) polymerization. The PEG-b-P(AM-co-AN) has chemical exchange saturation transfer (CEST) effects, which enable the use of CEST imaging for monitoring nanocarrier accumulation and providing molecular information of pathological tissues. Based on PEG-b-P(AM-co-AN), a new nanomedicine PEG-PAM-PAN@DOX was constructed by nano-precipitation. The self-assembling nature of PEG-PAM-PAN@DOX made the synthesis effective, straightforward, and biocompatible. In vitro studies demonstrate decreased cytotoxicity of PEG-PAM-PAN@DOX compared to free doxorubicin (half-maximal inhibitory concentration (IC50), mean ~ 0.62 μg/mL vs. ~ 5 μg/mL), and the nanomedicine more efficiently entered the cytoplasm and nucleus of cancer cells to kill them. Further, in vivo animal experiments showed that the nanomedicine developed was not only effective against breast cancer, but also displayed an excellent sensitive CEST effect for monitoring drug accumulation (at about 0.5 ppm) in tumor areas. The CEST signal of post-injection 2 h was significantly higher than that of pre-injection (2.17 ± 0.88% vs. 0. 09 ± 0.75%, p < 0.01). Conclusions The nanomedicine with CEST imaging reflects the characterization of tumors and therapeutic functions has great potential medical applications.

scholarly journals Monitoring food digestion with magnetic resonance techniques

2020 ◽  
pp. 1-11
Author(s):  
Paul A. M. Smeets ◽  
Ruoxuan Deng ◽  
Elise J. M. van Eijnatten ◽  
Morwarid Mayar
Keyword(s):  
Magnetic Resonance ◽  
Food Systems ◽  
Chemical Exchange ◽  
Quantitative Information ◽  
Model Systems ◽  
Chemical Exchange Saturation Transfer ◽  
Food Properties ◽  
Health And Disease

This review outlines the current use of magnetic resonance (MR) techniques to study digestion and highlights their potential for providing markers of digestive processes such as texture changes and nutrient breakdown. In vivo digestion research can be challenging due to practical constraints and biological complexity. Therefore, digestion is primarily studied using in vitro models. These would benefit from further in vivo validation. NMR is widely used to characterise food systems. MRI is a related technique that can be used to study both in vitro model systems and in vivo gastro-intestinal processes. MRI allows visualisation and quantification of gastric processes such as gastric emptying and coagulation. Both MRI and NMR scan sequences can be configured to be sensitive to different aspects of gastric or intestinal contents. For example, magnetisation transfer and chemical exchange saturation transfer can detect proton (1H) exchange between water and proteins. MRI techniques have the potential to provide molecular-level and quantitative information on in vivo gastric (protein) digestion. This requires careful validation in order to understand what these MR markers of digestion mean in a specific digestion context. Combined with other measures they can be used to validate and inform in vitro digestion models. This may bridge the gap between in vitro and in vivo digestion research and can aid the optimisation of food properties for different applications in health and disease.

scholarly journals Method for high-resolution imaging of creatine in vivo using chemical exchange saturation transfer

2013 ◽  
Vol 71 (1) ◽  
pp. 164-172 ◽  
Author(s):  
Feliks Kogan ◽  
Mohammad Haris ◽  
Anup Singh ◽  
Kejia Cai ◽  
Catherine Debrosse ◽  
...  
Keyword(s):  
High Resolution ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
High Resolution Imaging ◽  
Saturation Transfer ◽  
Resolution Imaging

Mo1951 Interleukin-29 (Interferon-Lambda 1) Inhibits Growth of Hepatocellular Carcinomas in an Orthotope Murine Tumor Model In Vivo

2012 ◽  
Vol 142 (5) ◽  
pp. S-706
Author(s):  
Bettina Schwarz ◽  
Florian Beigel ◽  
Karl W. Jauch ◽  
Burkhard Göke ◽  
Stephan Brand ◽  
...  
Keyword(s):  
Tumor Model ◽  
Murine Tumor ◽  
Interferon Lambda ◽  
Murine Tumor Model ◽  
Hepatocellular Carcinomas

scholarly journals In vivo multicolor molecular MR imaging using diamagnetic chemical exchange saturation transfer liposomes

2011 ◽  
Vol 67 (4) ◽  
pp. 1106-1113 ◽  
Author(s):  
Guanshu Liu ◽  
Matthew Moake ◽  
Yah-el Har-el ◽  
Chris M. Long ◽  
Kannie W.Y. Chan ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer

In vivo 19F MR Studies of Fluorine Labeled Photosensitizers in a Murine Tumor Model

2007 ◽  
Vol 4 (2) ◽  
pp. 126-132 ◽  
Author(s):  
Subbaraya Ramaprasad ◽  
Elzbieta Ripp ◽  
Joseph Missert
Keyword(s):  
Tumor Model ◽  
Mr Studies ◽  
Murine Tumor ◽  
Murine Tumor Model
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