scholarly journals On B 1 inhomogeneity correction of in vivo human brain glutamate chemical exchange saturation transfer contrast at 7T

2012 ◽  
Vol 69 (3) ◽  
pp. 818-824 ◽  
Author(s):  
Anup Singh ◽  
Kejia Cai ◽  
Mohammad Haris ◽  
Hari Hariharan ◽  
Ravinder Reddy
Keyword(s):  
Human Brain ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Inhomogeneity Correction

scholarly journals Novel nanomedicine with a chemical-exchange saturation transfer effect for breast cancer treatment in vivo

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Yanlong Jia ◽  
Chaochao Wang ◽  
Jiehua Zheng ◽  
Guisen Lin ◽  
Dalong Ni ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Chemical Exchange ◽  
Raft Polymerization ◽  
Animal Experiments ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Cest Imaging

Abstract Background Nanomedicine is a promising new approach to cancer treatment that avoids the disadvantages of traditional chemotherapy and improves therapeutic indices. However, the lack of a real-time visualization imaging technology to monitor drug distribution greatly limits its clinical application. Image-tracked drug delivery is of great clinical interest; it is useful for identifying those patients for whom the therapy is more likely to be beneficial. This paper discusses a novel nanomedicine that displays features of nanoparticles and facilitates functional magnetic resonance imaging but is challenging to prepare. Results To achieve this goal, we synthesized an acylamino-containing amphiphilic block copolymer (polyethylene glycol-polyacrylamide-polyacetonitrile, PEG-b-P(AM-co-AN)) by reversible addition-fragmentation chain transfer (RAFT) polymerization. The PEG-b-P(AM-co-AN) has chemical exchange saturation transfer (CEST) effects, which enable the use of CEST imaging for monitoring nanocarrier accumulation and providing molecular information of pathological tissues. Based on PEG-b-P(AM-co-AN), a new nanomedicine PEG-PAM-PAN@DOX was constructed by nano-precipitation. The self-assembling nature of PEG-PAM-PAN@DOX made the synthesis effective, straightforward, and biocompatible. In vitro studies demonstrate decreased cytotoxicity of PEG-PAM-PAN@DOX compared to free doxorubicin (half-maximal inhibitory concentration (IC50), mean ~ 0.62 μg/mL vs. ~ 5 μg/mL), and the nanomedicine more efficiently entered the cytoplasm and nucleus of cancer cells to kill them. Further, in vivo animal experiments showed that the nanomedicine developed was not only effective against breast cancer, but also displayed an excellent sensitive CEST effect for monitoring drug accumulation (at about 0.5 ppm) in tumor areas. The CEST signal of post-injection 2 h was significantly higher than that of pre-injection (2.17 ± 0.88% vs. 0. 09 ± 0.75%, p < 0.01). Conclusions The nanomedicine with CEST imaging reflects the characterization of tumors and therapeutic functions has great potential medical applications.

Chemical exchange saturation transfer MRI contrast in the human brain at 9.4 T

NeuroImage ◽  
2018 ◽  
Vol 179 ◽  
pp. 144-155 ◽  
Author(s):  
Moritz Zaiss ◽  
Mark Schuppert ◽  
Anagha Deshmane ◽  
Kai Herz ◽  
Philipp Ehses ◽  
...  
Keyword(s):  
Human Brain ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer ◽  
Mri Contrast

scholarly journals Method for high-resolution imaging of creatine in vivo using chemical exchange saturation transfer

2013 ◽  
Vol 71 (1) ◽  
pp. 164-172 ◽  
Author(s):  
Feliks Kogan ◽  
Mohammad Haris ◽  
Anup Singh ◽  
Kejia Cai ◽  
Catherine Debrosse ◽  
...  
Keyword(s):  
High Resolution ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
High Resolution Imaging ◽  
Saturation Transfer ◽  
Resolution Imaging

scholarly journals Quantifying amide proton exchange rate and concentration in chemical exchange saturation transfer imaging of the human brain

NeuroImage ◽  
2019 ◽  
Vol 189 ◽  
pp. 202-213 ◽  
Author(s):  
Hye-Young Heo ◽  
Zheng Han ◽  
Shanshan Jiang ◽  
Michael Schär ◽  
Peter C.M. van Zijl ◽  
...  
Keyword(s):  
Exchange Rate ◽  
Human Brain ◽  
Chemical Exchange ◽  
Proton Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Amide Proton ◽  
Saturation Transfer ◽  
Amide Proton Exchange

scholarly journals In vivo multicolor molecular MR imaging using diamagnetic chemical exchange saturation transfer liposomes

2011 ◽  
Vol 67 (4) ◽  
pp. 1106-1113 ◽  
Author(s):  
Guanshu Liu ◽  
Matthew Moake ◽  
Yah-el Har-el ◽  
Chris M. Long ◽  
Kannie W.Y. Chan ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Saturation Transfer
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