scholarly journals Direct monitoring of drug‐induced mechanical response of individual cells by atomic force microscopy

2020 ◽  
Vol 33 (9) ◽  
Author(s):  
Van‐Chien Bui ◽  
Thi‐Huong Nguyen
Keyword(s):  
Atomic Force Microscopy ◽  
Mechanical Response ◽  
Drug Induced ◽  
Force Microscopy ◽  
Atomic Force

scholarly journals Mechanical response of adherent giant liposomes to indentation with a conical AFM-tip

Soft Matter ◽  
2015 ◽  
Vol 11 (22) ◽  
pp. 4487-4495 ◽  
Author(s):  
Edith Schäfer ◽  
Marian Vache ◽  
Torben-Tobias Kliesch ◽  
Andreas Janshoff
Keyword(s):  
Mechanical Properties ◽  
Atomic Force Microscopy ◽  
Mechanical Response ◽  
Force Microscopy ◽  
Atomic Force

Mechanical properties of giant liposomes with actin cortices are determined with atomic force microscopy.

scholarly journals Atomic Force Microscopy Mechanical Mapping of Micropatterned Cells Shows Adhesion Geometry-Dependent Mechanical Response on Local and Global Scales

ACS Nano ◽  
2015 ◽  
Vol 9 (6) ◽  
pp. 5846-5856 ◽  
Author(s):  
Annafrancesca Rigato ◽  
Felix Rico ◽  
Frédéric Eghiaian ◽  
Mathieu Piel ◽  
Simon Scheuring
Keyword(s):  
Atomic Force Microscopy ◽  
Mechanical Response ◽  
Force Microscopy ◽  
Atomic Force

Probing arsenic trioxide (ATO) treated leukemia cell elasticities using atomic force microscopy

2020 ◽  
Vol 12 (39) ◽  
pp. 4734-4741
Author(s):  
Hélène Fortier ◽  
Valerie Gies ◽  
Fabio Variola ◽  
Chen Wang ◽  
Shan Zou
Keyword(s):  
Atomic Force Microscopy ◽  
Drug Treatment ◽  
Arsenic Trioxide ◽  
Mechanical Response ◽  
Leukemia Cell ◽  
Indentation Method ◽  
Force Microscopy ◽  
Atomic Force

Nanomechanical indentation method to unveil the relationships among biochemical, structural, morphological, and mechanical response to arsenic trioxide drug treatment.

Curing dependent spatial heterogeneity of mechanical response in epoxy resins revealed by atomic force microscopy

Polymer ◽  
2015 ◽  
Vol 68 ◽  
pp. 1-10 ◽  
Author(s):  
Amir Bahrami ◽  
Xavier Morelle ◽  
Lê Duy Hông Minh ◽  
Thomas Pardoen ◽  
Christian Bailly ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Spatial Heterogeneity ◽  
Epoxy Resins ◽  
Mechanical Response ◽  
Force Microscopy ◽  
Atomic Force

Sub-cellular Dynamic Mechanical Response Measurements of Live Human Pulmonary Artery Endothelial Cells with Atomic Force Microscopy

2012 ◽  
Vol 18 (S2) ◽  
pp. 1622-1623
Author(s):  
S. Avasthy ◽  
Y. Ishikawa ◽  
G. Shekhawat ◽  
V.P. Dravid ◽  
G. Mustata ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Endothelial Cells ◽  
Pulmonary Artery ◽  
Mechanical Response ◽  
Force Microscopy ◽  
Dynamic Mechanical ◽  
Atomic Force ◽  
Human Pulmonary Artery

Extended abstract of a paper presented at Microscopy and Microanalysis 2012 in Phoenix, Arizona, USA, July 29 – August 2, 2012.

scholarly journals On the frequency dependence of viscoelastic material characterization with intermittent-contact dynamic atomic force microscopy: avoiding mischaracterization across large frequency ranges

2020 ◽  
Vol 11 ◽  
pp. 1409-1418
Author(s):  
Enrique A López-Guerra ◽  
Santiago D Solares
Keyword(s):  
Atomic Force Microscopy ◽  
Mechanical Response ◽  
Viscoelastic Behavior ◽  
Partial Solution ◽  
Electromagnetic Properties ◽  
Multiple Characteristic ◽  
Force Microscopy ◽  
Atomic Force ◽  
Linear Viscoelastic ◽  
Intermittent Contact

Atomic force microscopy (AFM) is a widely use technique to acquire topographical, mechanical, or electromagnetic properties of surfaces, as well as to induce surface modifications at the micrometer and nanometer scale. Viscoelastic materials, examples of which include many polymers and biological materials, are an important class of systems, the mechanical response of which depends on the rate of application of the stresses imparted by the AFM tip. The mechanical response of these materials thus depends strongly on the frequency at which the characterization is performed, so much so that important aspects of behavior may be missed if one chooses an arbitrary characterization frequency regardless of the materials properties. In this paper we present a linear viscoelastic analysis of intermittent-contact, nearly resonant dynamic AFM characterization of such materials, considering the possibility of multiple characteristic times. We describe some of the intricacies observed in their mechanical response and alert the reader about situations where mischaracterization may occur as a result of probing the material at frequency ranges or with probes that preclude observation of its viscoelastic behavior. While we do not offer a solution to the formidable problem of inverting the frequency-dependent viscoelastic behavior of a material from dynamic AFM observables, we suggest that a partial solution is offered by recently developed quasi-static force–distance characterization techniques, which incorporate viscoelastic models with multiple characteristic times and can help inform dynamic AFM characterization.

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