Pathophysiological roles of chronic low‐grade inflammation mediators in polycystic ovary syndrome

2020 ◽  
Vol 236 (2) ◽  
pp. 824-838 ◽  
Author(s):  
Maryam Rostamtabar ◽  
Sedigheh Esmaeilzadeh ◽  
Mehdi Tourani ◽  
Abolfazl Rahmani ◽  
Masoud Baee ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Low Grade ◽  
Ovary Syndrome ◽  
Inflammation Mediators ◽  
Low Grade Inflammation

The Emerging Role of Chronic Low-Grade Inflammation in the Pathophysiology of Polycystic Ovary Syndrome

2015 ◽  
Vol 33 (04) ◽  
pp. 257-269 ◽  
Author(s):  
Soulmaz Shorakae ◽  
Helena Teede ◽  
Barbora de Courten ◽  
Gavin Lambert ◽  
Jacqueline Boyle ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Low Grade ◽  
Ovary Syndrome ◽  
Low Grade Inflammation

Indices of Low-Grade Inflammation in Polycystic Ovary Syndrome

2006 ◽  
Vol 1092 (1) ◽  
pp. 175-186 ◽  
Author(s):  
E. DIAMANTI-KANDARAKIS ◽  
T. PATERAKIS ◽  
H. A. KANDARAKIS
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Low Grade ◽  
Ovary Syndrome ◽  
Low Grade Inflammation

scholarly journals Central Fat Excess in Polycystic Ovary Syndrome: Relation to Low-Grade Inflammation and Insulin Resistance

2005 ◽  
Vol 90 (11) ◽  
pp. 6014-6021 ◽  
Author(s):  
Jardena J. Puder ◽  
Sabina Varga ◽  
Marius Kraenzlin ◽  
Christian De Geyter ◽  
Ulrich Keller ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Low Grade ◽  
Ovary Syndrome ◽  
Central Fat ◽  
Low Grade Inflammation

scholarly journals Oxidative Stress and Low-Grade Inflammation in Polycystic Ovary Syndrome: Controversies and New Insights

2021 ◽  
Vol 22 (4) ◽  
pp. 1667 ◽  
Author(s):  
Antonio Mancini ◽  
Carmine Bruno ◽  
Edoardo Vergani ◽  
Claudia d’Abate ◽  
Elena Giacchi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Vitamin D ◽  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Normal Weight ◽  
Low Grade ◽  
Ovary Syndrome ◽  
Low Grade Inflammation

The pathophysiology of Polycystic Ovary Syndrome (PCOS) is quite complex and different mechanisms could contribute to hyperandrogenism and anovulation, which are the main features of the syndrome. Obesity and insulin-resistance are claimed as the principal factors contributing to the clinical presentation; in normal weight PCOS either, increased visceral adipose tissue has been described. However, their role is still debated, as debated are the biochemical markers linked to obesity per se. Oxidative stress (OS) and low-grade inflammation (LGI) have recently been a matter of researcher attention; they can influence each other in a reciprocal vicious cycle. In this review, we summarize the main mechanism of radical generation and the link with LGI. Furthermore, we discuss papers in favor or against the role of obesity as the first pathogenetic factor, and show how OS itself, on the contrary, can induce obesity and insulin resistance; in particular, the role of GH-IGF-1 axis is highlighted. Finally, the possible consequences on vitamin D synthesis and activation on the immune system are briefly discussed. This review intends to underline the key role of oxidative stress and low-grade inflammation in the physiopathology of PCOS, they can cause or worsen obesity, insulin-resistance, vitamin D deficiency, and immune dyscrasia, suggesting an inverse interaction to what is usually considered.

The relationship between follistatin and chronic low-grade inflammation in women with polycystic ovary syndrome

2009 ◽  
Vol 92 (6) ◽  
pp. 2041-2044 ◽  
Author(s):  
Mei-Jou Chen ◽  
Hsin-Fu Chen ◽  
Shee-Uan Chen ◽  
Hong-Nerng Ho ◽  
Yu-Shih Yang ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Low Grade ◽  
Ovary Syndrome ◽  
Low Grade Inflammation ◽  
The Relationship

Association between Biomarkers of Low-grade Inflammation and Sex Hormones in Women with Polycystic Ovary Syndrome

2019 ◽  
Vol 128 (11) ◽  
pp. 723-730 ◽  
Author(s):  
Erifili Hatziagelaki ◽  
Vasilios Pergialiotis ◽  
Julia M. Kannenberg ◽  
Eftihios Trakakis ◽  
Anastasia Tsiavou ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Sex Hormones ◽  
Polycystic Ovary ◽  
Free Testosterone ◽  
Endocrine Function ◽  
Sex Hormone Binding Globulin ◽  
Low Grade ◽  
Ovary Syndrome ◽  
Reactive Protein ◽  
Low Grade Inflammation

Abstract Objective Women with polycystic ovary syndrome (PCOS) have higher circulating levels of C-reactive protein, but the relationship between inflammation and endocrine function in PCOS remains poorly understood. Thus, this study aimed to investigate the association between low-grade inflammation and sex hormones in women with PCOS. Design and Patients A comprehensive panel of biomarkers of inflammation was measured in serum of 63 women with PCOS using proximity extension assay technology. Associations of 65 biomarkers with sex hormones were assessed without and with adjustment for age and body mass index (BMI). Results In the unadjusted analysis, 20 biomarkers were positively correlated with 17-OH-progesterone (17-OH-P), 14 with prolactin and 6 with free testosterone, whereas inverse associations were found for 16 biomarkers with sex hormone-binding globulin (SHBG), 6 with luteinizing hormone (LH) and 6 with estrogen (all p<0.05). Among the positive associations, correlations were mainly found for five chemokines (CXCL11, CCL4, MCP-4/CCL13, CXCL5, CXCL6) and for VEGF-A, LAP-TGFβ1, TNFSF14 and MMP-1. Inverse associations with sex hormones were mainly present for two chemokines (CXCL1, MCP-2/CCL8), CDCP1, CST5 and CSF-1. Adjustment for age and BMI reduced the number of biomarker associations for SHBG and estrogen, but had hardly any impact on associations with 17-OH-P, prolactin, free testosterone and LH. Conclusion Women with PCOS feature BMI-independent associations between biomarkers of inflammation and certain sex steroid and hypophyseal hormones. Most of these inflammation-related biomarkers were chemokines, which may be relevant as potential mediators of the increased cardiometabolic risk of women with PCOS.

scholarly journals Obesity, but not polycystic ovary syndrome, affects circulating markers of low-grade inflammation in young women without major cardiovascular risk factors

HORMONES ◽  
2015 ◽  
pp. 251-257 ◽  
Author(s):  
Cristiano Roberto Barcellos ◽  
Michelle Patrocínio Rocha ◽  
Sylvia Asaka Hayashida ◽  
Wagner Silva Dantas ◽  
Viviane dos Reis Vieira Yance ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Polycystic Ovary Syndrome ◽  
Cardiovascular Risk Factors ◽  
Young Women ◽  
Polycystic Ovary ◽  
Low Grade ◽  
Ovary Syndrome ◽  
Circulating Markers ◽  
Low Grade Inflammation
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