Mitochondria‐targeted antioxidant mito‐TEMPO alleviate oxidative stress induced by antimycin A in human mesenchymal stem cells

2020 ◽  
Vol 235 (7-8) ◽  
pp. 5628-5636 ◽  
Author(s):  
Abolfazl Barzegari ◽  
Mohammad Nouri ◽  
Virginie Gueguen ◽  
Nazli Saeedi ◽  
Graciela Pavon‐Djavid ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Antimycin A

Human Mesenchymal Stem Cells Efficiently Manage Oxidative Stress

2010 ◽  
Vol 19 (12) ◽  
pp. 1885-1893 ◽  
Author(s):  
Araceli Valle-Prieto ◽  
Paulette A. Conget
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells

scholarly journals Pretreatment with Lycopene Attenuates Oxidative Stress-Induced Apoptosis in Human Mesenchymal Stem Cells

2015 ◽  
Vol 23 (6) ◽  
pp. 517-524 ◽  
Author(s):  
Ji Yong Kim ◽  
Jai-Sung Lee ◽  
Yong-Seok Han ◽  
Jun Hee Lee ◽  
Inhyu Bae ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Induced Apoptosis

scholarly journals Quantification of Chlorogenic Acid and Vanillin from Coffee Peel Extract and its Effect on α-Amylase Activity, Immunoregulation, Mitochondrial Oxidative Stress, and Tumor Suppressor Gene Expression Levels in H2O2-Induced Human Mesenchymal Stem Cells

2021 ◽  
Vol 12 ◽  
Author(s):  
Heba Khalil Alyahya ◽  
Pandurangan Subash-Babu ◽  
Ahmad Mohammad Salamatullah ◽  
Khizar Hayat ◽  
Nawal Albader ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tumor Suppressor ◽  
Chlorogenic Acid ◽  
Tumor Suppressor Genes ◽  
Human Mesenchymal Stem Cells ◽  
Total Polyphenol ◽  
Suppressor Genes ◽  
Mitochondrial Oxidative Stress

Background: Polyphenols and flavonoid-rich foods help in arresting reactive oxygen species development and protecting DNA from oxidative damage. Coffee peel (CP) preparations are consumed as beverages, and their total polyphenol or flavonoid content and their effect on oxidative stress–induced human mesenchymal stem cells (hMSCs) are poorly understood.Method: We prepared hot water extracts of CP (CPE) and quantified the amount of total polyphenol and flavonoid using HPLC analysis. In addition, CPE have been studied for their α-amylase inhibitory effect and beneficial effects in oxidative stress–induced hMSCs.Results: The obtained results show that the availability of chlorogenic acid, vanillin, and salicylic acid levels in CPE is more favorable for enhancing cell growth, nuclear integrity, and mitochondrial efficiency which is confirmed by propidium iodide staining and JC-1 staining. CPE treatment to hMSCs for 48 h reduced oxidative stress by decreasing mRNA expression levels of LPO and NOX-4 and in increasing antioxidant CYP1A, GSH, GSK-3β, and GPX mRNA expressions. Decreased pro-inflammatory (TNF-α, NF-κβ, IL-1β, TLR-4) and increased tumor suppressor genes (except Bcl-2) such as Cdkn2A, p53 expressions have been observed.Conclusions: The availability of CGA in CPs effectively reduced mitochondrial oxidative stress, reduced pro-inflammatory cytokines, and increased tumor suppressor genes.

Telomere dynamics in human mesenchymal stem cells after exposure to acute oxidative stress

DNA Repair ◽  
2012 ◽  
Vol 11 (9) ◽  
pp. 774-779 ◽  
Author(s):  
Maria Harbo ◽  
Steen Koelvraa ◽  
Nedime Serakinci ◽  
Laila Bendix
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Telomere Dynamics
Sign in / Sign up

Export Citation Format

Share Document