Adipose tissue‐derived stem cells upon decellularized ovine small intestine submucosa for tissue regeneration: An optimization and comparison method

2019 ◽  
Vol 235 (2) ◽  
pp. 1556-1567
Author(s):  
Ahad Ferdowsi Khosroshahi ◽  
Jafar Soleimani Rad ◽  
Razie Kheirjou ◽  
Babak Roshangar ◽  
Morteza Rashtbar ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Small Intestine ◽  
Tissue Regeneration ◽  
Comparison Method ◽  
Small Intestine Submucosa

Tracheal reconstruction by mesenchymal stem cells with small intestine submucosa in rabbits

2012 ◽  
Vol 76 (3) ◽  
pp. 345-351 ◽  
Author(s):  
Xiao Fei Du ◽  
Seong Keun Kwon ◽  
Jae-Jun Song ◽  
Chang Gun Cho ◽  
Seok-Won Park
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Small Intestine ◽  
Small Intestine Submucosa ◽  
Tracheal Reconstruction

Tissue Regeneration in Loss of Substance on the Lower Limbs through Use of Platelet-Rich Plasma, Stem Cells from Adipose Tissue, and Hyaluronic Acid

2010 ◽  
Vol 23 (6) ◽  
pp. 262-272 ◽  
Author(s):  
Valerio Cervelli ◽  
Barbara De Angelis ◽  
Lucilla Lucarini ◽  
Diana Spallone ◽  
Alberto Balzani ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Hyaluronic Acid ◽  
Tissue Regeneration ◽  
Platelet Rich Plasma ◽  
Lower Limbs

scholarly journals CXCR4 Overexpression in Human Adipose Tissue-Derived Stem Cells Improves Homing and Engraftment in an Animal Limb Ischemia Model

2017 ◽  
Vol 26 (2) ◽  
pp. 191-204 ◽  
Author(s):  
Mijung Kim ◽  
Dong-Ik Kim ◽  
Eun Key Kim ◽  
Chan-Wha Kim
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Muscle Tissue ◽  
Tissue Regeneration ◽  
Transfection Efficiency ◽  
Limb Ischemia ◽  
Human Adipose Tissue ◽  
Hindlimb Ischemia ◽  
Systemic Injection

We investigated the effects of transplantation of CXCR4-overexpressing adipose tissue-derived stem cells (ADSCs) into a mouse diabetic hindlimb ischemia model on homing and engraftment as early as 48 h after transplant. CXCR4-overexpressing ADSCs were intramuscularly or intravenously injected into diabetic mice with hindlimb ischemia. After 48 h, muscle tissues in the femur and tibia were collected, and the CXCR4 expression pattern was analyzed by immunofluorescence staining. The homing and engraftment of transplanted CXCR4-overexpressing ADSCs into the ischemic area were significantly increased, and intravenous (systemic) injection resulted in the more effective delivery of stem cells to the target site 48 h posttransplantation. Furthermore, CXCR4-overexpressing ADSCs more efficiently contributed to long-term engraftment and muscle tissue regeneration than normal ADSCs in a limb ischemia model. In addition, the homing and engraftment of ADSCs were correlated with the CXCR4 transfection efficiency. These results demonstrated that enhanced CXCR4 signaling could significantly improve the early homing and engraftment of ADSCs into ischemic areas as well as the long-term engraftment and ultimate muscle tissue regeneration.

scholarly journals Creation of an Artificial Artery Using Adipose-Derived Stem Cells (ASCs) and Small Intestine Submucosa (SIS)

2013 ◽  
Vol 58 (4) ◽  
pp. 1147-1148
Author(s):  
Kathleen M. Lamb ◽  
Aleksandra Policha ◽  
Lily Chang ◽  
Masaya Jimbo ◽  
Ping Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Small Intestine ◽  
Adipose Derived Stem Cells ◽  
Small Intestine Submucosa

scholarly journals Towards a Comprehensive Understanding of UA-ADRCs (Uncultured, Autologous, Fresh, Unmodified, Adipose Derived Regenerative Cells, Isolated at Point of Care) in Regenerative Medicine

Cells ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 1097 ◽  
Author(s):  
Eckhard U. Alt ◽  
Glenn Winnier ◽  
Alexander Haenel ◽  
Ralf Rothoerl ◽  
Oender Solakoglu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Regenerative Medicine ◽  
Tissue Regeneration ◽  
Adult Stem Cells ◽  
Point Of Care ◽  
Initial Mixture ◽  
Physiological Capacity ◽  
Regenerative Cells ◽  
Regenerate Tissue

It has become practically impossible to survey the literature on cells derived from adipose tissue for regenerative medicine. The aim of this paper is to provide a comprehensive and translational understanding of the potential of UA-ADRCs (uncultured, unmodified, fresh, autologous adipose derived regenerative cells isolated at the point of care) and its application in regenerative medicine. We provide profound basic and clinical evidence demonstrating that tissue regeneration with UA-ADRCs is safe and effective. ADRCs are neither ‘fat stem cells’ nor could they exclusively be isolated from adipose tissue. ADRCs contain the same adult stem cells ubiquitously present in the walls of blood vessels that are able to differentiate into cells of all three germ layers. Of note, the specific isolation procedure used has a significant impact on the number and viability of cells and hence on safety and efficacy of UA-ADRCs. Furthermore, there is no need to specifically isolate and separate stem cells from the initial mixture of progenitor and stem cells found in ADRCs. Most importantly, UA-ADRCs have the physiological capacity to adequately regenerate tissue without need for more than minimally manipulating, stimulating and/or (genetically) reprogramming the cells for a broad range of clinical applications. Tissue regeneration with UA-ADRCs fulfills the criteria of homologous use as defined by the regulatory authorities.

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