Adipose Tissue Derived- Stem Cells: Applications and Benefits in Tissue Regeneration

2017 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Azam Asemi Rad
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Tissue Regeneration

Tissue Regeneration in Loss of Substance on the Lower Limbs through Use of Platelet-Rich Plasma, Stem Cells from Adipose Tissue, and Hyaluronic Acid

2010 ◽  
Vol 23 (6) ◽  
pp. 262-272 ◽  
Author(s):  
Valerio Cervelli ◽  
Barbara De Angelis ◽  
Lucilla Lucarini ◽  
Diana Spallone ◽  
Alberto Balzani ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Hyaluronic Acid ◽  
Tissue Regeneration ◽  
Platelet Rich Plasma ◽  
Lower Limbs

scholarly journals CXCR4 Overexpression in Human Adipose Tissue-Derived Stem Cells Improves Homing and Engraftment in an Animal Limb Ischemia Model

2017 ◽  
Vol 26 (2) ◽  
pp. 191-204 ◽  
Author(s):  
Mijung Kim ◽  
Dong-Ik Kim ◽  
Eun Key Kim ◽  
Chan-Wha Kim
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Muscle Tissue ◽  
Tissue Regeneration ◽  
Transfection Efficiency ◽  
Limb Ischemia ◽  
Human Adipose Tissue ◽  
Hindlimb Ischemia ◽  
Systemic Injection

We investigated the effects of transplantation of CXCR4-overexpressing adipose tissue-derived stem cells (ADSCs) into a mouse diabetic hindlimb ischemia model on homing and engraftment as early as 48 h after transplant. CXCR4-overexpressing ADSCs were intramuscularly or intravenously injected into diabetic mice with hindlimb ischemia. After 48 h, muscle tissues in the femur and tibia were collected, and the CXCR4 expression pattern was analyzed by immunofluorescence staining. The homing and engraftment of transplanted CXCR4-overexpressing ADSCs into the ischemic area were significantly increased, and intravenous (systemic) injection resulted in the more effective delivery of stem cells to the target site 48 h posttransplantation. Furthermore, CXCR4-overexpressing ADSCs more efficiently contributed to long-term engraftment and muscle tissue regeneration than normal ADSCs in a limb ischemia model. In addition, the homing and engraftment of ADSCs were correlated with the CXCR4 transfection efficiency. These results demonstrated that enhanced CXCR4 signaling could significantly improve the early homing and engraftment of ADSCs into ischemic areas as well as the long-term engraftment and ultimate muscle tissue regeneration.

scholarly journals Towards a Comprehensive Understanding of UA-ADRCs (Uncultured, Autologous, Fresh, Unmodified, Adipose Derived Regenerative Cells, Isolated at Point of Care) in Regenerative Medicine

Cells ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 1097 ◽  
Author(s):  
Eckhard U. Alt ◽  
Glenn Winnier ◽  
Alexander Haenel ◽  
Ralf Rothoerl ◽  
Oender Solakoglu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Regenerative Medicine ◽  
Tissue Regeneration ◽  
Adult Stem Cells ◽  
Point Of Care ◽  
Initial Mixture ◽  
Physiological Capacity ◽  
Regenerative Cells ◽  
Regenerate Tissue

It has become practically impossible to survey the literature on cells derived from adipose tissue for regenerative medicine. The aim of this paper is to provide a comprehensive and translational understanding of the potential of UA-ADRCs (uncultured, unmodified, fresh, autologous adipose derived regenerative cells isolated at the point of care) and its application in regenerative medicine. We provide profound basic and clinical evidence demonstrating that tissue regeneration with UA-ADRCs is safe and effective. ADRCs are neither ‘fat stem cells’ nor could they exclusively be isolated from adipose tissue. ADRCs contain the same adult stem cells ubiquitously present in the walls of blood vessels that are able to differentiate into cells of all three germ layers. Of note, the specific isolation procedure used has a significant impact on the number and viability of cells and hence on safety and efficacy of UA-ADRCs. Furthermore, there is no need to specifically isolate and separate stem cells from the initial mixture of progenitor and stem cells found in ADRCs. Most importantly, UA-ADRCs have the physiological capacity to adequately regenerate tissue without need for more than minimally manipulating, stimulating and/or (genetically) reprogramming the cells for a broad range of clinical applications. Tissue regeneration with UA-ADRCs fulfills the criteria of homologous use as defined by the regulatory authorities.

scholarly journals Recent Developments in Extracellular Matrix Remodeling for Fat Grafting

2021 ◽  
Vol 9 ◽  
Author(s):  
Xin Bi ◽  
Ye Li ◽  
Ziqing Dong ◽  
Jing Zhao ◽  
Weizi Wu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Extracellular Matrix ◽  
Adipose Tissue ◽  
Tissue Regeneration ◽  
Retention Rate ◽  
Fat Grafting ◽  
Matrix Remodeling ◽  
Ecm Remodeling ◽  
Dynamic Relationship ◽  
Recent Developments

Remodeling of the extracellular matrix (ECM), which provides structural and biochemical support for surrounding cells, is vital for adipose tissue regeneration after autologous fat grafting. Rapid and high-quality ECM remodeling can improve the retention rate after fat grafting by promoting neovascularization, regulating stem cells differentiation, and suppressing chronic inflammation. The degradation and deposition of ECM are regulated by various factors, including hypoxia, blood supply, inflammation, and stem cells. By contrast, ECM remodeling alters these regulatory factors, resulting in a dynamic relationship between them. Although researchers have attempted to identify the cellular sources of factors associated with tissue regeneration and regulation of the microenvironment, the factors and mechanisms that affect adipose tissue ECM remodeling remain incompletely understood. This review describes the process of adipose ECM remodeling after grafting and summarizes the factors that affect ECM reconstruction. Also, this review provides an overview of the clinical methods to avoid poor ECM remodeling. These findings may provide new ideas for improving the retention of adipose tissue after fat transplantation.

scholarly journals A Comprehensive Understanding of UA-ADRCs (Uncultured, Autologous, Fresh, Unmodified, Adipose Derived Regenerative Cells, Isolated at Point of Care) in Regenerative Medicine

2020 ◽  
Author(s):  
Eckhard Alt ◽  
Glenn Winnier ◽  
Alexander Haenel ◽  
Ralf Rothoerl ◽  
Oender Solakoglu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Regenerative Medicine ◽  
Tissue Regeneration ◽  
Point Of Care ◽  
Adipose Derived Stem Cells ◽  
Multipotent Stem Cells ◽  
Physiological Capacity ◽  
Regenerative Cells ◽  
Regenerate Tissue

It has become practically impossible to survey the literature on cells derived from adipose tissue with the aim to apply them in regenerative medicine. The aim of this review is to provide a jump start to understanding the potential of UA-ADRCs (uncultured, unmodified, fresh, autologous adipose derived regenerative cells isolated at the point of care) in regenerative medicine. We show that serious and adequate clinical research demonstrates that tissue regeneration with UA-ADRCs is safe and effective. ADRCs are neither 'fat stem cells' nor could they exclusively be isolated from adipose tissue, as ADRCs contain the same adult (depending on the definition) pluripotent or multipotent stem cells that are ubiquitously present in the walls of small blood vessels. Of note, the specific isolation procedure used has significant impact on the number and viability of the cells and hence on safety and efficacy of UA-ADRCs. Furthermore, there is no need to further separate adipose-derived stem cells (ASCs) from ADRCs if the latter were adequately isolated from adipose tissue. Most importantly, UA-ADRCs have the physiological capacity to adequately regenerate tissue without need for manipulating, stimulating and/or (genetically) reprogramming the cells for this purpose. Tissue regeneration with UA-ADRCs fulfills the criteria of homologous use.

scholarly journals Adipose tissue-derived mesenchymal stem cells for breast tissue regeneration

2021 ◽  
Vol 16 (1) ◽  
pp. 47-70
Author(s):  
Mohammed A Banani ◽  
Mohammed Rahmatullah ◽  
Nawras Farhan ◽  
Zoe Hancox ◽  
Safiyya Yousaf ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Tissue Regeneration ◽  
Breast Tissue ◽  
Psychological Impact ◽  
Tissue Formation ◽  
Tissue Modeling ◽  
Host Interaction

With an escalating incidence of breast cancer cases all over the world and the deleterious psychological impact that mastectomy has on patients along with several limitations of the currently applied modalities, it's plausible to seek unconventional approaches to encounter such a burgeoning issue. Breast tissue engineering may allow that chance via providing more personalized solutions which are able to regenerate, mimicking natural tissues also facing the witnessed limitations. This review is dedicated to explore the utilization of adipose tissue-derived mesenchymal stem cells for breast tissue regeneration among postmastectomy cases focusing on biomaterials and cellular aspects in terms of harvesting, isolation, differentiation and new tissue formation as well as scaffolds types, properties, material–host interaction and an in vitro breast tissue modeling.

Periodontal tissue regeneration by transplantation of adipose tissue-derived stem cells

2013 ◽  
Vol 55 (3) ◽  
pp. 137-142 ◽  
Author(s):  
Masahide Takedachi ◽  
Keigo Sawada ◽  
Satomi Yamamoto ◽  
Masao Ozasa ◽  
Yoshio Shimabukuro ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Tissue Regeneration ◽  
Periodontal Tissue ◽  
Periodontal Tissue Regeneration

scholarly journals Bifunctional scaffolds for the photothermal therapy of breast tumor cells and adipose tissue regeneration

2018 ◽  
Vol 6 (46) ◽  
pp. 7728-7736 ◽  
Author(s):  
Xiuhui Wang ◽  
Jing Zhang ◽  
Jingchao Li ◽  
Ying Chen ◽  
Yazhou Chen ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Tumor Cells ◽  
Tissue Regeneration ◽  
Gold Nanorods ◽  
Breast Tumor ◽  
Photothermal Therapy ◽  
Adipogenic Differentiation ◽  
Composite Scaffolds ◽  
Breast Tumor Cells

Bifunctional composite scaffolds of gold nanorods and gelatin can ablate tumor cells and promote the adipogenic differentiation of stem cells.

In vivo injectable human adipose tissue regeneration by adipose-derived stem cells isolated from the fluid portion of liposuction aspirates

2014 ◽  
Vol 46 (3) ◽  
pp. 178-184 ◽  
Author(s):  
Ziqing Dong ◽  
Lin Luo ◽  
Yunjun Liao ◽  
Yunsong Zhang ◽  
Jianhua Gao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Adipose Tissue ◽  
Tissue Regeneration ◽  
Human Adipose Tissue ◽  
Adipose Derived Stem Cells
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