Systematic QM/MM investigation of factors that affect the cytochrome P450-catalyzed hydrogen abstraction of camphor

2006 ◽  
Vol 27 (12) ◽  
pp. 1324-1337 ◽  
Author(s):  
Ahmet Altun ◽  
Sason Shaik ◽  
Walter Thiel
Keyword(s):  
Cytochrome P450 ◽  
Hydrogen Abstraction

Prediction of Activation Energies for Hydrogen Abstraction by Cytochrome P450

2006 ◽  
Vol 49 (22) ◽  
pp. 6489-6499 ◽  
Author(s):  
Lars Olsen ◽  
Patrik Rydberg ◽  
Thomas H. Rod ◽  
Ulf Ryde
Keyword(s):  
Cytochrome P450 ◽  
Hydrogen Abstraction ◽  
Activation Energies

Molecular evolution of a cytochrome P450 for the synthesis of potential antidepressant (2R,6R)-hydroxynorketamine

2021 ◽  
Author(s):  
Ansgar Bokel ◽  
Michael C. Hutter ◽  
Vlada B. Urlacher
Keyword(s):  
Cytochrome P450 ◽  
Molecular Evolution ◽  
Cytochrome P450 Monooxygenase ◽  
P450 Monooxygenase ◽  
Effective Synthesis

Engineered cytochrome P450 monooxygenase CYP154E1 enables the effective synthesis of the potential antidepressant (2R,6R)-hydroxynorketamine via N-demethylation and regio- and stereoselective hydroxylation of (R)-ketamine.

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