The effect of ICRT‐3 on Wnt signaling pathway in head and neck cancer

2018 ◽  
Vol 120 (1) ◽  
pp. 380-395 ◽  
Author(s):  
Fatma Sogutlu ◽  
Cagla Kayabasi ◽  
Besra Ozmen Yelken ◽  
Aycan Asik ◽  
Roya Gasimli ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Wnt Signaling ◽  
Head And Neck ◽  
Signaling Pathway ◽  
Neck Cancer ◽  
Wnt Signaling Pathway

scholarly journals The Significance of the Dysregulation of Canonical Wnt Signaling in Head and Neck Squamous Cell Carcinomas

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 723 ◽  
Author(s):  
Jarosław Paluszczak
Keyword(s):  
Cell Proliferation ◽  
Head And Neck Cancer ◽  
Wnt Signaling ◽  
Head And Neck ◽  
Neck Cancer ◽  
Squamous Cell ◽  
Wnt Signaling Pathway ◽  
Squamous Cell Carcinomas ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt

The knowledge about the molecular alterations which are found in head and neck squamous cell carcinomas (HNSCC) has much increased in recent years. However, we are still awaiting the translation of this knowledge to new diagnostic and therapeutic options. Among the many molecular changes that are detected in head and neck cancer, the abnormalities in several signaling pathways, which regulate cell proliferation, cell death and stemness, seem to be especially promising with regard to the development of targeted therapies. Canonical Wnt signaling is a pathway engaged in the formation of head and neck tissues, however it is not active in adult somatic mucosal cells. The aim of this review paper is to bring together significant data related to the current knowledge on the mechanisms and functional significance of the dysregulation of the Wnt/β-catenin pathway in head and neck tumors. Research evidence related to the role of Wnt signaling activation in the stimulation of cell proliferation, migration and inhibition of apoptosis in HNSCC is presented. Moreover, its role in promoting stemness traits in head and neck cancer stem-like cells is described. Evidence corroborating the hypothesis that the Wnt signaling pathway is a very promising target of novel therapeutic interventions in HNSCC is also discussed.

scholarly journals Wnt signaling controls radiosensitivityvia cyclooxygenase-2-mediated Ku expression in head and neck cancer

2007 ◽  
Vol 122 (1) ◽  
pp. 100-107 ◽  
Author(s):  
Hyo Won Chang ◽  
Jong-Lyel Roh ◽  
Eun-Jeong Jeong ◽  
Sang-wook Lee ◽  
Seung-Whan Kim ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Wnt Signaling ◽  
Head And Neck ◽  
Neck Cancer ◽  
Cyclooxygenase 2

scholarly journals Roles of the Wnt Signaling Pathway in Head and Neck Squamous Cell Carcinoma

2021 ◽  
Vol 7 ◽  
Author(s):  
Jing Xie ◽  
Li Huang ◽  
You-Guang Lu ◽  
Da-Li Zheng
Keyword(s):  
Squamous Cell Carcinoma ◽  
Wnt Signaling ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Signaling Pathway ◽  
Squamous Cell ◽  
Wnt Pathway ◽  
Wnt Signaling Pathway ◽  
Neck Squamous Cell Carcinoma ◽  
Upstream Gene

Head and neck squamous cell carcinoma (HNSCC) is the most common type of head and neck tumor. It is a high incidence malignant tumor associated with a low survival rate and limited treatment options. Accumulating conclusions indicate that the Wnt signaling pathway plays a vital role in the pathobiological process of HNSCC. The canonical Wnt/β-catenin signaling pathway affects a variety of cellular progression, enabling tumor cells to maintain and further promote the immature stem-like phenotype, proliferate, prolong survival, and gain invasiveness. Genomic studies of head and neck tumors have shown that although β-catenin is not frequently mutated in HNSCC, its activity is not inhibited by mutations in upstream gene encoding β-catenin, NOTCH1, FAT1, and AJUBA. Genetic defects affect the components of the Wnt pathway in oral squamous cell carcinoma (OSCC) and the epigenetic mechanisms that regulate inhibitors of the Wnt pathway. This paper aims to summarize the groundbreaking discoveries and recent advances involving the Wnt signaling pathway and highlight the relevance of this pathway in head and neck squamous cell cancer, which will help provide new insights into improving the treatment of human HNSCC by interfering with the transcriptional signaling of Wnt.

Role of the NOTCH Signaling Pathway in Head and Neck Cancer

2018 ◽  
pp. 229-248
Author(s):  
Adrian D. Schubert ◽  
Fernando T. Zamuner ◽  
Nyall R. London ◽  
Alex Zhavoronkov ◽  
Ranee Mehra ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Notch Signaling ◽  
Head And Neck ◽  
Signaling Pathway ◽  
Neck Cancer ◽  
Notch Signaling Pathway
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