scholarly journals Wnt signaling controls radiosensitivityvia cyclooxygenase-2-mediated Ku expression in head and neck cancer

2007 ◽  
Vol 122 (1) ◽  
pp. 100-107 ◽  
Author(s):  
Hyo Won Chang ◽  
Jong-Lyel Roh ◽  
Eun-Jeong Jeong ◽  
Sang-wook Lee ◽  
Seung-Whan Kim ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Wnt Signaling ◽  
Head And Neck ◽  
Neck Cancer ◽  
Cyclooxygenase 2

scholarly journals The Significance of the Dysregulation of Canonical Wnt Signaling in Head and Neck Squamous Cell Carcinomas

Cells ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 723 ◽  
Author(s):  
Jarosław Paluszczak
Keyword(s):  
Cell Proliferation ◽  
Head And Neck Cancer ◽  
Wnt Signaling ◽  
Head And Neck ◽  
Neck Cancer ◽  
Squamous Cell ◽  
Wnt Signaling Pathway ◽  
Squamous Cell Carcinomas ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt

The knowledge about the molecular alterations which are found in head and neck squamous cell carcinomas (HNSCC) has much increased in recent years. However, we are still awaiting the translation of this knowledge to new diagnostic and therapeutic options. Among the many molecular changes that are detected in head and neck cancer, the abnormalities in several signaling pathways, which regulate cell proliferation, cell death and stemness, seem to be especially promising with regard to the development of targeted therapies. Canonical Wnt signaling is a pathway engaged in the formation of head and neck tissues, however it is not active in adult somatic mucosal cells. The aim of this review paper is to bring together significant data related to the current knowledge on the mechanisms and functional significance of the dysregulation of the Wnt/β-catenin pathway in head and neck tumors. Research evidence related to the role of Wnt signaling activation in the stimulation of cell proliferation, migration and inhibition of apoptosis in HNSCC is presented. Moreover, its role in promoting stemness traits in head and neck cancer stem-like cells is described. Evidence corroborating the hypothesis that the Wnt signaling pathway is a very promising target of novel therapeutic interventions in HNSCC is also discussed.

Inhibition of Cyclooxygenase-2 Expression: An Approach to Preventing Head and Neck Cancer

1999 ◽  
Vol 889 (1 CANCER PREVEN) ◽  
pp. 62-71 ◽  
Author(s):  
JUAN R. MESTRE ◽  
GEORGETTE CHAN ◽  
FAN ZHANG ◽  
EUN K. YANG ◽  
PETER G. SACKS ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Cyclooxygenase 2

The Cyclooxygenase-2 Inhibitor Nimesulide, a Nonsteroidal Analgesic, Decreases the Effect of Radiation Therapy in Head-and-Neck Cancer Cells

2009 ◽  
Vol 185 (5) ◽  
pp. 310-317 ◽  
Author(s):  
Cornelia Czembirek ◽  
Christina Eder-Czembirek ◽  
Boban M. Erovic ◽  
Dritan Turhani ◽  
Andreas Spittler ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Cells ◽  
Neck Cancer ◽  
Cyclooxygenase 2

The effect of nimesulide, a selective cyclooxygenase-2 inhibitor, on Ets-1 and Ets-2 expression in head and neck cancer cell lines

Head & Neck ◽  
2005 ◽  
Vol 27 (12) ◽  
pp. 1068-1072 ◽  
Author(s):  
Wolfgang Lamm ◽  
Laurenz Vormittag ◽  
Dritan Turhani ◽  
Boban M. Erovic ◽  
Cornelia Czembirek ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cell Lines ◽  
Cancer Cell ◽  
Neck Cancer ◽  
Cancer Cell Lines ◽  
Cyclooxygenase 2

The effect of ICRT‐3 on Wnt signaling pathway in head and neck cancer

2018 ◽  
Vol 120 (1) ◽  
pp. 380-395 ◽  
Author(s):  
Fatma Sogutlu ◽  
Cagla Kayabasi ◽  
Besra Ozmen Yelken ◽  
Aycan Asik ◽  
Roya Gasimli ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Wnt Signaling ◽  
Head And Neck ◽  
Signaling Pathway ◽  
Neck Cancer ◽  
Wnt Signaling Pathway

Cyclooxygenase-2: A novel molecular target for the prevention and treatment of head and neck cancer

Head & Neck ◽  
2002 ◽  
Vol 24 (8) ◽  
pp. 792-799 ◽  
Author(s):  
Derrick T. Lin ◽  
Kotha Subbaramaiah ◽  
Jatin P. Shah ◽  
Andrew J. Dannenberg ◽  
Jay O. Boyle
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Molecular Target ◽  
Cyclooxygenase 2 ◽  
Prevention And Treatment
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