Transcriptome Analysis of Canine Cardiac Fat Pads: Involvement of Two Novel Long Non-Coding RNAs in Atrial Fibrillation Neural Remodeling

2015 ◽  
Vol 116 (5) ◽  
pp. 809-821 ◽  
Author(s):  
Weizong Wang ◽  
Ximin Wang ◽  
Yujiao Zhang ◽  
Zhan Li ◽  
Xinxing Xie ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Transcriptome Analysis ◽  
Non Coding Rnas ◽  
Neural Remodeling ◽  
Fat Pads

Whole Transcriptome Analysis: Implication to Estrous Cycle Regulation

2021 ◽  
Author(s):  
Xiaopeng An ◽  
Yue Zhang ◽  
Fu Li ◽  
Zhanhang Wang ◽  
Shaohua Yang ◽  
...  
Keyword(s):  
Estrous Cycle ◽  
Transcriptome Analysis ◽  
Circular Rna ◽  
Differentially Expressed ◽  
Non Coding Rna ◽  
Non Coding Rnas ◽  
Whole Transcriptome Analysis ◽  
Cycle Regulation ◽  
Whole Transcriptome ◽  
Goat Ovary

Abstract BackgroundEstrous cycle is one of female characteristics after sexual maturity, including estrus (ES) and diestrus (DS) stages. Estrous cycle is important in female physiology and its disorder may lead to diseases. In the latest years, effects of non-coding RNAs and mRNA on estrous cycle start to arouse much concern, however, a whole transcriptome analysis among non-coding RNAs and mRNA has not been reported.ResultsHere we report a whole transcriptome analysis of goat ovary in estrus and diestrus periods. Estrus synchronization was conducted to induce the estrus phase and on day 32, the goats naturally shifted into diestrus stage. The ovary RNA of estrus and diestrus stages was respectively collected to perform RNA-sequencing. Then the circular RNA; microRNA; long non-coding RNA; mRNA databases of goat ovary were acquired, and the differentially expressions between estrus and diestrus stages were screened to construct circRNA-miRNA-mRNA/lncRNA and lncRNA-miRNA/mRNA networks, thus providing potential pathways that involved in the regulation of estrous cycle. Differentially expressed mRNAs, such as MMP9, TIMP1, 3BHSD and PTGIS, and differentially expressed microRNAs, such as miR-21-3p，miR-202-3p and miR-223-3p, which play key roles in estrous cycle regulation were extracted from the network.ConclusionsOur data provided the miRNA, circRNA, lncRNA and mRNA databases of goat ovary and each differentially expressed profile between ES and DS. Networks among differentially expressed miRNAs, circRNAs, lncRNAs and mRNAs were constructed to provide valuable resources for the study of estrous cycle and related diseases.

scholarly journals Effects of Renal Denervation via Renal Artery Adventitial Cryoablation on Atrial Fibrillation and Cardiac Neural Remodeling

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Wei Wang ◽  
Zhaolei Jiang ◽  
Rongxin Lu ◽  
Hao Liu ◽  
Nan Ma ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Renal Artery ◽  
Renal Denervation ◽  
Sham Group ◽  
Stellate Ganglion ◽  
Sympathetic Nerves ◽  
Postoperative Recovery ◽  
Therapeutic Approaches ◽  
Neural Remodeling ◽  
Renal Sympathetic

Introduction. Catheter-based renal denervation (RDN) could reduce cardiac sympathetic nerve activity (SNA) and inhibit atrial fibrillation (AF). However, the reliability is uncertain, because the renal sympathetic nerves are mainly distributed in the adventitial surface of the renal artery. Objective. The aims of this study were to test the hypothesis that renal artery adventitial ablation (RAAA) definitely had the effects of RDN and to study the effects of RDN via renal artery adventitial cryoablation (RAAC) on AF and cardiac neural remodeling. Methods. Twenty beagle canines were randomly assigned to two groups: the left RDN group (LRDN, n=10), which underwent left RDN via RAAC; the Sham group (n=10). After 2 months of postoperative recovery, AF vulnerability, AF duration, and histological examination were performed in both groups. Results. Compared with the Sham group, left stellate ganglion (LSG) tissue fibrosis was increased in the LRDN group. LRDN significantly increased the percentage of TH-negative ganglionic cells and decreased the density of TH-positive nerves in the LSG (P<0.001). Also, the densities of TH-positive nerves and GAP43 immunoreactivity within the left atrium (LA) were significantly decreased in the LRDN group (P<0.05). After LA burst pacing, all 10 canines (100%) could be induced AF in the Sham group, but only 4 of 10 canines (40%) could be induced AF in the LRDN group (P=0.011). The percentage of LA burst stimulation with induced AF was 26.7% (8/30) in the LRDN group, which was significantly decreased compared with that of the Sham group (53.3%, 16/30) (P=0.035). In addition, AF duration was also significantly decreased in the LRDN group (13.3 ± 5.1 s) compared with that of the Sham group (20.3 ± 7.3 s, P=0.024). Conclusions. RDN via RAAC could cause cardiac neural remodeling and effectively inhibit AF inducibility and shorten AF duration. It may be useful in selecting therapeutic approaches for AF patients.

Atrial Heterogeneous Autonomic Neural Remodeling in Rabbits with Experimental Atrial Fibrillation and the Effect of Intervention by Rosuvastatin

2016 ◽  
Vol 39 (6) ◽  
pp. 598-606 ◽  
Author(s):  
BEI ZHANG ◽  
XIMIN WANG ◽  
ZHAN LI ◽  
WEIZONG WANG ◽  
YONG ZHANG ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Neural Remodeling

scholarly journals Transcriptome analysis identifies the potential roles of long non‐coding RNAs during parainfluenza virus infection

FEBS Letters ◽  
2018 ◽  
Vol 592 (14) ◽  
pp. 2444-2457
Author(s):  
Haoming Wu ◽  
Ran‐Ran Yao ◽  
Shuang‐Shuang Yu ◽  
Hong‐Yan Chen ◽  
Juan Cai ◽  
...  
Keyword(s):  
Virus Infection ◽  
Transcriptome Analysis ◽  
Parainfluenza Virus ◽  
Non Coding Rnas

scholarly journals Transcriptome analysis of long non-coding RNAs of the nucleus accumbens in cocaine-conditioned mice

2012 ◽  
Vol 123 (5) ◽  
pp. 790-799 ◽  
Author(s):  
Qian Bu ◽  
Zhengtao Hu ◽  
Feng Chen ◽  
Ruiming Zhu ◽  
Yi Deng ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Transcriptome Analysis ◽  
Non Coding Rnas
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