scholarly journals Identification of long non-coding RNAs as novel biomarker and potential therapeutic target for atrial fibrillation in old adults

Oncotarget ◽  
2016 ◽  
Vol 7 (10) ◽  
pp. 10803-10811 ◽  
Author(s):  
Yingjia Xu ◽  
Ritai Huang ◽  
Jianing Gu ◽  
Weifeng Jiang
Keyword(s):  
Atrial Fibrillation ◽  
Therapeutic Target ◽  
Potential Therapeutic Target ◽  
Old Adults ◽  
Non Coding Rnas

scholarly journals MiR-29a: a potential therapeutic target and promising biomarker in tumors

2018 ◽  
Vol 38 (1) ◽  
Author(s):  
Jin-yan Wang ◽  
Qian Zhang ◽  
Dan-dan Wang ◽  
Wei Yan ◽  
Huan-huan Sha ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Therapeutic Target ◽  
Therapeutic Strategy ◽  
Transcriptional Level ◽  
Additional Insight ◽  
Potential Therapeutic Target ◽  
Rna Molecules ◽  
Non Coding Rna ◽  
Non Coding Rnas ◽  
Novel Therapeutic

MiRNAs, small non-coding RNA molecules, were recognized to be associated with the incidence and development of diverse neoplasms. MiRNAs were small non-coding RNAs that could regulate post-transcriptional level by binding to 3′-UTR of target mRNAs. Amongst which, miR-29a was demonstrated that it had significant impact on oncogenicity in various neoplasms through binding to critical genes which enhanced or inhibited the progression of cancers. MiR-29a participated in kinds of physiological and pathological processes, including virus replication, cell proliferation, differentiation, apoptosis, fibrosis, angiogenesis, tumorigenicity, metastasis, drug-resistance, and so on. According to its sufficient sensitivity and specificity, many studies showed that miR-29a might serve as a potential therapeutic target and promising biomarker in various tumors. In this review, we discussed the functions of miR-29a and its potential application in the diagnosis, treatment and stages of carcinoma, which could provide additional insight to develop a novel therapeutic strategy.

OPG/RANK/RANKL Axis as a Potential Therapeutic Target for Atrial Fibrillation

Cardiology ◽  
2013 ◽  
Vol 125 (3) ◽  
pp. 173-173
Author(s):  
Hui Tao ◽  
Kai-hu Shi ◽  
Jing-Jing Yang
Keyword(s):  
Atrial Fibrillation ◽  
Therapeutic Target ◽  
Potential Therapeutic Target
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