scholarly journals Current Physical Activity Is Independently Associated With Cortical Bone Size and Bone Strength in Elderly Swedish Women

2016 ◽  
Vol 32 (3) ◽  
pp. 473-485 ◽  
Author(s):  
Martin Nilsson ◽  
Daniel Sundh ◽  
Dan Mellström ◽  
Mattias Lorentzon
Keyword(s):  
Physical Activity ◽  
Cortical Bone ◽  
Bone Strength ◽  
Bone Size

scholarly journals Physical activity when young provides lifelong benefits to cortical bone size and strength in men

2014 ◽  
Vol 111 (14) ◽  
pp. 5337-5342 ◽  
Author(s):  
S. J. Warden ◽  
S. M. Mantila Roosa ◽  
M. E. Kersh ◽  
A. L. Hurd ◽  
G. S. Fleisig ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cortical Bone ◽  
Bone Size

scholarly journals Associations of objectively and subjectively measured physical activity with trabecular and cortical bone properties in prepubertal children

2014 ◽  
Vol 26 (2) ◽  
pp. 48
Author(s):  
Rebecca Mary Meiring ◽  
Joanne Alexandra McVeigh
Keyword(s):  
Physical Activity ◽  
Cortical Bone ◽  
Bone Strength ◽  
Intraclass Correlation ◽  
Quantitative Computed Tomography ◽  
Correlation Coefficients ◽  
Peripheral Quantitative Computed Tomography ◽  
Prepubertal Children ◽  
Tibial Diaphysis ◽  
Bone Properties

Objectives. To compare the relationship between peak bone strain scores (PBSSs) calculated from physical activity (PA) questionnaires and accelerometry measures of PA with trabecular and cortical bone properties in prepubertal children.Methods. We compared PBSSs calculated from the bone-specific component of PA questionnaires with accelerometry and bone mass measures in 38 prepubertal children (mean 9.9 (standard deviation 1.3) years). Dual energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) were used to assess bone content and structure, and to estimate bone strength at the radial and tibial diaphysis and radial metaphysis. Results. The PBSS was reliable and reproducible with significant (p<0.001) intraclass correlation coefficients. There were significant correlations between PBSS and moderate (r=0.38; p=0.02), vigorous (r=0.36; p=0.03) and combined moderate- to vigorous-intensity activity counts (r=0.38; p=0.02). PBSS was significantly correlated to body size-adjusted bone mineral content at all sites scanned by DXA (r=0.33 - 0.48; p<0.05). Positive correlations were observed between PBSS and area, density and strength at the radius and tibia (r=0.40 - 0.64; p<0.05). Only vigorous activity was correlated to cortical area at the radial diaphysis (r=0.37; p=0.03) and bone strength at the tibial diaphysis (r=0.32; p=0.05). Activity as assessed by the PBSS explained a greater amount of variance in bone variables as measured by DXA and pQCT than accelerometer-measured PA. Conclusion. Accelerometer-measured moderate and vigorous habitual PA is associated with indices of cortical bone size and geometry in children, whereas light PA has no detectable association. Furthermore, the bone-specific questionnaire appears to be more strongly associated with bone outcomes than accelerometer-derived measures of PA.

scholarly journals Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Basel M. Al-Barghouthi ◽  
Larry D. Mesner ◽  
Gina M. Calabrese ◽  
Daniel Brooks ◽  
Steven M. Tommasini ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Bone Strength ◽  
Human Genetics ◽  
Association Studies ◽  
Systems Genetics ◽  
Genome Wide Association Studies ◽  
Mineral Density ◽  
Diversity Outbred ◽  
Wide Range ◽  
Genetics Of Osteoporosis

AbstractGenome-wide association studies (GWASs) for osteoporotic traits have identified over 1000 associations; however, their impact has been limited by the difficulties of causal gene identification and a strict focus on bone mineral density (BMD). Here, we use Diversity Outbred (DO) mice to directly address these limitations by performing a systems genetics analysis of 55 complex skeletal phenotypes. We apply a network approach to cortical bone RNA-seq data to discover 66 genes likely to be causal for human BMD GWAS associations, including the genes SERTAD4 and GLT8D2. We also perform GWAS in the DO for a wide-range of bone traits and identify Qsox1 as a gene influencing cortical bone accrual and bone strength. In this work, we advance our understanding of the genetics of osteoporosis and highlight the ability of the mouse to inform human genetics.

scholarly journals The role of cortical bone and its microstructure in bone strength

2006 ◽  
Vol 35 (suppl_2) ◽  
pp. ii27-ii31 ◽  
Author(s):  
Peter Augat ◽  
Sandra Schorlemmer
Keyword(s):  
Cortical Bone ◽  
Bone Strength

Reduced physical activity corresponds with greater bone loss at the trabecular than the cortical bone sites in men

Bone ◽  
2009 ◽  
Vol 45 (6) ◽  
pp. 1073-1078 ◽  
Author(s):  
Taru Tervo ◽  
Peter Nordström ◽  
Martin Neovius ◽  
Anna Nordström
Keyword(s):  
Physical Activity ◽  
Bone Loss ◽  
Cortical Bone ◽  
Reduced Physical Activity
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