Increased physical activity is associated with optimized development of peak bone mass mainly due to augmented cortical bone size in men: A five year longitudinal study

Bone ◽  
2011 ◽  
Vol 48 ◽  
pp. S88
Author(s):  
M. Nilsson ◽  
C. Ohlsson ◽  
A. Odén ◽  
D. Mellström ◽  
M. Lorentzon
Keyword(s):  
Physical Activity ◽  
Longitudinal Study ◽  
Bone Mass ◽  
Cortical Bone ◽  
Peak Bone Mass ◽  
Bone Size

Insulin Resistance Is Associated With Smaller Cortical Bone Size in Nondiabetic Men at the Age of Peak Bone Mass

2016 ◽  
Vol 102 (6) ◽  
pp. 1807-1815 ◽  
Author(s):  
Charlotte Verroken ◽  
Hans-Georg Zmierczak ◽  
Stefan Goemaere ◽  
Jean-Marc Kaufman ◽  
Bruno Lapauw
Keyword(s):  
Insulin Resistance ◽  
Bone Mass ◽  
Cortical Bone ◽  
Peak Bone Mass ◽  
Bone Size

scholarly journals Increased physical activity is associated with enhanced development of peak bone mass in men: A five‐year longitudinal study

2012 ◽  
Vol 27 (5) ◽  
pp. 1206-1214 ◽  
Author(s):  
Martin Nilsson ◽  
Claes Ohlsson ◽  
Anders Odén ◽  
Dan Mellström ◽  
Mattias Lorentzon
Keyword(s):  
Physical Activity ◽  
Longitudinal Study ◽  
Bone Mass ◽  
Peak Bone Mass

scholarly journals Serum Estradiol Is Associated With Volumetric BMD and Modulates the Impact of Physical Activity on Bone Size at the Age of Peak Bone Mass: A Study in Healthy Male Siblings

2009 ◽  
Vol 24 (6) ◽  
pp. 1075-1085 ◽  
Author(s):  
Bruno M Lapauw ◽  
Youri Taes ◽  
Veerle Bogaert ◽  
Griet Vanbillemont ◽  
Stefan Goemaere ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bone Mass ◽  
Peak Bone Mass ◽  
Bone Size ◽  
Serum Estradiol ◽  
Healthy Male ◽  
Volumetric Bmd ◽  
The Impact

scholarly journals Sex Hormone-Binding Globulin as an Independent Determinant of Cortical Bone Status in Men at the Age of Peak Bone Mass

2010 ◽  
Vol 95 (4) ◽  
pp. 1579-1586 ◽  
Author(s):  
Griet Vanbillemont ◽  
Bruno Lapauw ◽  
Veerle Bogaert ◽  
Stefan Goemaere ◽  
Hans-Georg Zmierczak ◽  
...  
Keyword(s):  
Bone Mass ◽  
Cortical Bone ◽  
Peak Bone Mass ◽  
Bone Size ◽  
Whole Body ◽  
Sex Steroid ◽  
Bone Area ◽  
Mineral Density ◽  
Bone Parameters ◽  
Volumetric Bmd

Abstract Context: Sex steroids are important determinants of the skeletal development, growth, and maintenance after achievement of peak bone mass. A large fraction of these hormones are bound by SHBG, and previous studies have shown that SHBG could be a determinant of bone characteristics. Objective: We investigated associations of serum SHBG levels with cortical and trabecular bone characteristics in young healthy men. Design and Settings: A total of 677 healthy male siblings aged 25–45 yr were recruited in a cross-sectional, population-based study. Main Outcomes: Areal bone parameters were assessed using dual-energy x-ray absorptiometry. Cortical bone parameters at the tibia and radius and trabecular vBMD at the radius were assessed using peripheral quantitative computed tomography. Serum testosterone, estradiol, and SHBG levels were measured using immunoassays. Results: Regression models including age, height, and weight showed that SHBG levels were positively associated with bone area at the hip and the whole body, but not with areal bone mineral density (BMD). Higher SHBG levels were associated with a larger cortical bone area and periosteal and endosteal circumferences at both the tibia and the radius, whereas trabecular volumetric BMD at the radius was negatively associated with SHBG levels. Associations persisted after adjustment for (free) sex steroid levels. No associations were found with cortical volumetric BMD or cortical thickness. Conclusion: In this population of healthy adult men at the age of peak bone mass, SHBG levels were positively associated with cortical bone size, independently from sex-steroid levels. This suggests a possible independent role of SHBG in the determination of adult bone size.

Oral contraceptive use by teenage women does not affect peak bone mass: a longitudinal study

2000 ◽  
Vol 74 (4) ◽  
pp. 734-738 ◽  
Author(s):  
Tom Lloyd ◽  
Denise S Taylor ◽  
Hung Mo Lin ◽  
Amy E Matthews ◽  
Douglas F Eggli ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Oral Contraceptive ◽  
Bone Mass ◽  
Peak Bone Mass ◽  
Contraceptive Use ◽  
Oral Contraceptive Use

scholarly journals Cortical bone adaptation to a moderate level of mechanical loading in male Sost deficient mice

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Haisheng Yang ◽  
Alexander Büttner ◽  
Laia Albiol ◽  
Catherine Julien ◽  
Tobias Thiele ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bone Formation ◽  
Bone Mass ◽  
Cortical Bone ◽  
Bone Adaptation ◽  
Moderate Level ◽  
Skeletal Maturation ◽  
Male Mice ◽  
Males And Females

AbstractLoss-of-function mutations in the Sost gene lead to high bone mass phenotypes. Pharmacological inhibition of Sost/sclerostin provides a new drug strategy for treating osteoporosis. Questions remain as to how physical activity may affect bone mass under sclerostin inhibition and if that effect differs between males and females. We previously observed in female Sost knockout (KO) mice an enhanced cortical bone formation response to a moderate level of applied loading (900 με at the tibial midshaft). The purpose of the present study was to examine cortical bone adaptation to the same strain level applied to male Sost KO mice. Strain-matched in vivo compressive loading was applied to the tibiae of 10-, 26- and 52-week-old male Sost KO and littermate control (LC) mice. The effect of tibial loading on bone (re)modeling was measured by microCT, 3D time-lapse in vivo morphometry, 2D histomorphometry and gene expression analyses. As expected, Sost deficiency led to high cortical bone mass in 10- and 26-week-old male mice as a result of increased bone formation. However, the enhanced bone formation associated with Sost deficiency did not appear to diminish with skeletal maturation. An increase in bone resorption was observed with skeletal maturation in male LC and Sost KO mice. Two weeks of in vivo loading (900 με at the tibial midshaft) induced only a mild anabolic response in 10- and 26-week-old male mice, independent of Sost deficiency. A decrease in the Wnt inhibitor Dkk1 expression was observed 3 h after loading in 52-week-old Sost KO and LC mice, and an increase in Lef1 expression was observed 8 h after loading in 10-week-old Sost KO mice. The current results suggest that long-term inhibition of sclerostin in male mice does not influence the adaptive response of cortical bone to moderate levels of loading. In contrast with our previous strain-matched study in females showing enhanced bone responses with Sost ablation, these results in males indicate that the influence of Sost deficiency on the cortical bone formation response to a moderate level of loading differs between males and females. Clinical studies examining antibodies to inhibit sclerostin may need to consider that the efficacy of additional physical activity regimens may be sex dependent.

scholarly journals Influence of a School-based Physical Activity Intervention on Cortical Bone Mass Distribution: A 7-year Intervention Study

2016 ◽  
Vol 99 (5) ◽  
pp. 443-453 ◽  
Author(s):  
Jesper Fritz ◽  
Rachel L. Duckham ◽  
Timo Rantalainen ◽  
Björn E. Rosengren ◽  
Magnus K. Karlsson ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bone Mass ◽  
Cortical Bone ◽  
Mass Distribution ◽  
Intervention Study ◽  
Physical Activity Intervention ◽  
School Based ◽  
Cortical Bone Mass
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