scholarly journals The role of cortical bone and its microstructure in bone strength

2006 ◽  
Vol 35 (suppl_2) ◽  
pp. ii27-ii31 ◽  
Author(s):  
Peter Augat ◽  
Sandra Schorlemmer
Keyword(s):  
Cortical Bone ◽  
Bone Strength

scholarly journals Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Basel M. Al-Barghouthi ◽  
Larry D. Mesner ◽  
Gina M. Calabrese ◽  
Daniel Brooks ◽  
Steven M. Tommasini ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Bone Strength ◽  
Human Genetics ◽  
Association Studies ◽  
Systems Genetics ◽  
Genome Wide Association Studies ◽  
Mineral Density ◽  
Diversity Outbred ◽  
Wide Range ◽  
Genetics Of Osteoporosis

AbstractGenome-wide association studies (GWASs) for osteoporotic traits have identified over 1000 associations; however, their impact has been limited by the difficulties of causal gene identification and a strict focus on bone mineral density (BMD). Here, we use Diversity Outbred (DO) mice to directly address these limitations by performing a systems genetics analysis of 55 complex skeletal phenotypes. We apply a network approach to cortical bone RNA-seq data to discover 66 genes likely to be causal for human BMD GWAS associations, including the genes SERTAD4 and GLT8D2. We also perform GWAS in the DO for a wide-range of bone traits and identify Qsox1 as a gene influencing cortical bone accrual and bone strength. In this work, we advance our understanding of the genetics of osteoporosis and highlight the ability of the mouse to inform human genetics.

Supportive Role of Probiotic Strains in Protecting Rats from Ovariectomy-Induced Cortical Bone Loss

2018 ◽  
Vol 11 (4) ◽  
pp. 1145-1154 ◽  
Author(s):  
Nima Montazeri-Najafabady ◽  
Younes Ghasemi ◽  
Mohammad Hossein Dabbaghmanesh ◽  
Pedram Talezadeh ◽  
Farhad Koohpeyma ◽  
...  
Keyword(s):  
Bone Loss ◽  
Cortical Bone ◽  
Cortical Bone Loss ◽  
Supportive Role ◽  
Probiotic Strains

The role of cortical bone fenestration in the management of Mohs surgical scalp wounds devoid of periosteum

2009 ◽  
Vol 160 (5) ◽  
pp. 1110-1112 ◽  
Author(s):  
R.B.M. Barry ◽  
J.A.A. Langtry ◽  
C.M. Lawrence
Keyword(s):  
Cortical Bone

scholarly journals Unraveling the Role of Structure and Density in Determining Vertebral Bone Strength

1997 ◽  
Vol 61 (6) ◽  
pp. 474-479 ◽  
Author(s):  
J. F. Veenland ◽  
T. M. Link ◽  
W. Konermann ◽  
N. Meier ◽  
J. L. Grashuis ◽  
...  
Keyword(s):  
Bone Strength ◽  
Vertebral Bone

scholarly journals Outlook of short finned implants in the posterior maxilla‐ the role of cortical bone thickness

2019 ◽  
Vol 30 (S19) ◽  
pp. 157-158
Author(s):  
Igor Linetskiy ◽  
Vladislav Demenko ◽  
Vitalij Nesvit ◽  
Larysa Linetska ◽  
Oleg Yefremov
Keyword(s):  
Cortical Bone ◽  
Bone Thickness ◽  
Cortical Bone Thickness ◽  
Posterior Maxilla

scholarly journals Holmium-YAG Laser ablation characteristics in calvarial lamellar and cortical bone: The role of water and tissue micro-architecture

1995 ◽  
Vol 10 (3) ◽  
pp. 181-188 ◽  
Author(s):  
Brian Jet -Fei Wong ◽  
Vivian Sung ◽  
Michael W. Berns ◽  
Lars O. Svaasand ◽  
Joseph Neev
Keyword(s):  
Laser Ablation ◽  
Cortical Bone ◽  
Yag Laser ◽  
Ablation Characteristics

Healing of Cortical Bone Grafts in the Dog The Role of Azathioprine

1982 ◽  
Vol 11 (2) ◽  
pp. 52-59 ◽  
Author(s):  
BAYO J. ADEYANJU ◽  
HUGH C. BUTLER ◽  
HORST W. LEIPOLD
Keyword(s):  
Cortical Bone ◽  
Bone Grafts

scholarly journals Porcupine inhibitors impair trabecular and cortical bone mass and strength in mice

2018 ◽  
Vol 238 (1) ◽  
pp. 13-23 ◽  
Author(s):  
Thomas Funck-Brentano ◽  
Karin H Nilsson ◽  
Robert Brommage ◽  
Petra Henning ◽  
Ulf H Lerner ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Bone Loss ◽  
Bone Formation ◽  
Bone Mass ◽  
Trabecular Bone ◽  
Cortical Bone ◽  
Bone Strength ◽  
Bending Test ◽  
Bone Homeostasis ◽  
Mineral Density

WNT signaling is involved in the tumorigenesis of various cancers and regulates bone homeostasis. Palmitoleoylation of WNTs by Porcupine is required for WNT activity. Porcupine inhibitors are under development for cancer therapy. As the possible side effects of Porcupine inhibitors on bone health are unknown, we determined their effects on bone mass and strength. Twelve-week-old C57BL/6N female mice were treated by the Porcupine inhibitors LGK974 (low dose = 3 mg/kg/day; high dose = 6 mg/kg/day) or Wnt-C59 (10 mg/kg/day) or vehicle for 3 weeks. Bone parameters were assessed by serum biomarkers, dual-energy X-ray absorptiometry, µCT and histomorphometry. Bone strength was measured by the 3-point bending test. The Porcupine inhibitors were well tolerated demonstrated by normal body weight. Both doses of LGK974 and Wnt-C59 reduced total body bone mineral density compared with vehicle treatment (P < 0.001). Cortical thickness of the femur shaft (P < 0.001) and trabecular bone volume fraction in the vertebral body (P < 0.001) were reduced by treatment with LGK974 or Wnt-C59. Porcupine inhibition reduced bone strength in the tibia (P < 0.05). The cortical bone loss was the result of impaired periosteal bone formation and increased endocortical bone resorption and the trabecular bone loss was caused by reduced trabecular bone formation and increased bone resorption. Porcupine inhibitors exert deleterious effects on bone mass and strength caused by a combination of reduced bone formation and increased bone resorption. We suggest that cancer targeted therapies using Porcupine inhibitors may increase the risk of fractures.

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