In vivo evaluation of bone repair guided with biological membrane based on polyhydroxybutyrate and norbixin

2021 ◽  
Author(s):  
Rayssilane C. Sousa ◽  
Vicente G. F. Viana ◽  
Luiz F. C. Meneses ◽  
Antônio L. M. Maia Filho ◽  
Francisco E. P. Santos ◽  
...  
Keyword(s):  
Bone Repair ◽  
Biological Membrane ◽  
In Vivo Evaluation

IN VIVO EVALUATION OF BOVINE XENOGRAFT ASSOCIATED WITH OXYGEN THERAPY IN ALVEOLAR BONE REPAIR

2020 ◽  
Author(s):  
Camila Saggioro ◽  
Suelen Sartoretto ◽  
Isabelle Duarte ◽  
Adriana Alves ◽  
Helder Barreto ◽  
...  
Keyword(s):  
Bone Repair ◽  
Alveolar Bone ◽  
Healing Process ◽  
Active Oxygen ◽  
Control Group ◽  
Wound Healing Process ◽  
Bovine Bone ◽  
In Vivo Evaluation ◽  
Significant Difference

In order to preserve alveolar bone thickness and width after extraction, clinical strategies have been adopted to reduce or eliminate the need for future surgical interventions to increase the alveolar ridge. The use of xenogeneic biomaterials has been increasing for such application. The association of bone substitutes with active oxygen-based materials, which is essential in the wound healing process, could accelerate the bone repair, optimizing the maintenance of alveolar architecture after extraction. However, the truth of this hypothesis is not clear. The present study aimed to compare the biological response to inorganic bovine bone graft Bonefill® (BF), associated or not with active oxygen-based gel Oral gel Blue ® m (BF+BM), in alveolar bone repair. Twenty female Wistar rats were randomly distributed, the left upper central incisor was extracted and the dental sockets were filled with BF in the control group (n=10), and with BF+BM in the experimental group (n=10). After 7- and 42-days’ post implantation (n=5), the animals were euthanized, and the samples were processed for descriptive histological and histomorphometric evaluations. The results showed no significant difference between the groups (p>0.05). Both groups presented a time-dependent increase of new formed bone and biosorption biomaterial (p=0.0001). While the biomaterial analyzed was considered compatible and osteoconductive, the association with Blue ® m gel did not improve or interfere with the bone repair after the experimental periods.

Synthesis and in vivo evaluation of a scaffold containing wollastonite/β‐TCP for bone repair in a rabbit tibial defect model

2019 ◽  
Vol 108 (3) ◽  
pp. 1107-1116 ◽  
Author(s):  
Willams T. Barbosa ◽  
Katilayne V. Almeida ◽  
Gabriel G. Lima ◽  
Miguel A. Rodriguez ◽  
Marcos V. Lia Fook ◽  
...  
Keyword(s):  
Bone Repair ◽  
Defect Model ◽  
In Vivo Evaluation ◽  
Tibial Defect

Calcium phosphate fibers coated with collagen: In vivo evaluation of the effects on bone repair

2016 ◽  
Vol 27 (2-3) ◽  
pp. 259-273 ◽  
Author(s):  
Fabio Roberto Ueno ◽  
Hueliton Wilian Kido ◽  
Renata Neves Granito ◽  
Paulo Roberto Gabbai-Armelin ◽  
Angela Maria Paiva Magri ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Repair ◽  
In Vivo Evaluation

scholarly journals Plantago ovata F. Mucilage-Alginate Mucoadhesive Beads for Controlled Release of Glibenclamide: Development, Optimization, and In Vitro-In Vivo Evaluation

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Amit Kumar Nayak ◽  
Dilipkumar Pal ◽  
Kousik Santra
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Biological Membrane ◽  
Diabetic Rats ◽  
Plantago Ovata ◽  
Drug Release Profile ◽  
Sustained Drug Release ◽  
In Vivo Evaluation

The current study deals with the development and optimization of ispaghula (Plantago ovata F.) husk mucilage- (IHM-) alginate mucoadhesive beads containing glibenclamide by ionotropic gelation technique. The effects of sodium alginate (SA) to IHM and cross-linker (CaCl2) concentration on the drug encapsulation efficiency (DEE, %), as well as cumulative drug release after 10 hours (R10 h, %), were optimized using 32 factorial design based on response surface methodology. The observed responses were coincided well with the predicted values by the experimental design. The optimized mucoadhesive beads exhibited 94.43±4.80% w/w of DEE and good mucoadhesivity with the biological membrane in wash-off test and sustained drug release profile over 10 hours. The beads were also characterized by SEM and FTIR analyses. The in vitro drug release from these beads was followed by controlled release (zero-order) pattern with super case-II transport mechanism. The optimized glibenclamide-loaded IHM-alginate mucoadhesive beads showed significant antidiabetic effect in alloxan-induced diabetic rats over prolonged period after oral administration.

Radiolabelling and in vivo evaluation of [11C]GSK215083 as potential PET radioligand for the 5-HT6 receptor in the porcine brain

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S598-S598 ◽  
Author(s):  
Laurent Martarello ◽  
Vincent J Cunningham ◽  
Julian C Matthews ◽  
Eugenii Rabiner ◽  
Steen Jakobsen ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Porcine Brain

In vivo evaluation of [11C]CNS-5161 as a use-dependent ligand for the NMDA glutamate receptor channel

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S595-S595 ◽  
Author(s):  
Wynne K Schiffer ◽  
Deborah Pareto-Onghena ◽  
HaiTao Wu ◽  
Kuo-Shyan Lin ◽  
Andrew R Gibbs ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
In Vivo Evaluation ◽  
Nmda Glutamate Receptor ◽  
Receptor Channel

In vitro and in vivo evaluation of the anti-inflammatory effects of Arzanol from Helichrysum italicum

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
J Bauer ◽  
F Dehm ◽  
A Koeberle ◽  
F Pollastro ◽  
G Appendino ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Anti Inflammatory

The supraannular concept – in-vivo evaluation of 5 aortic bioprostheses

2008 ◽  
Vol 56 (S 1) ◽  
Author(s):  
D Ruzicka ◽  
W Eichinger ◽  
I Hettich ◽  
S Bleiziffer ◽  
R Guenzinger ◽  
...  
Keyword(s):  
In Vivo Evaluation
Sign in / Sign up

Export Citation Format

Share Document