Calcium phosphate fibers coated with collagen: In vivo evaluation of the effects on bone repair

2016 ◽  
Vol 27 (2-3) ◽  
pp. 259-273 ◽  
Author(s):  
Fabio Roberto Ueno ◽  
Hueliton Wilian Kido ◽  
Renata Neves Granito ◽  
Paulo Roberto Gabbai-Armelin ◽  
Angela Maria Paiva Magri ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Repair ◽  
In Vivo Evaluation

Processing and in vivo evaluation of multiphasic calcium phosphate cements with dual tricalcium phosphate phases

2012 ◽  
Vol 8 (9) ◽  
pp. 3500-3508 ◽  
Author(s):  
Marco A. Lopez-Heredia ◽  
Matilde Bongio ◽  
Marc Bohner ◽  
Vincent Cuijpers ◽  
Louis A.J.A. Winnubst ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
In Vivo Evaluation ◽  
Calcium Phosphate Cements

scholarly journals Preliminary in Vivo Evaluation of Bone Healing in Critical Size Bone Defects Implanted with an Injectable Calcium Phosphate Bone Cement (Osteopaste)

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Che Nor Zarida Che Seman ◽  
Zamzuri Zakaria ◽  
Zunariah Buyong ◽  
Mohd Shukrimi Awang ◽  
Ahmad Razali Md Ralib @ Md Raghib
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Bone Tissue ◽  
Bone Repair ◽  
Critical Size ◽  
Healing Process ◽  
Bone Defects ◽  
Calcium Phosphate Bone Cement ◽  
Rabbit Tibia

Introduction: A novel injectable calcium phosphate bone cement (osteopaste) has been developed. Its potential application in orthopaedics as a filler of bone defects has been studied. The biomaterial was composed of tetra-calcium phosphate (TTCP) and tricalcium phosphate (TCP) powder. The aim of the present study was to evaluate the healing process of osteopaste in rabbit tibia. Materials and method: The implantation procedure was carried out on thirty-nine of New Zealand white rabbits. The in vivo bone formation was investigated by either implanting the Osteopaste, Jectos or MIIG – X3 into a critical size defect (CSD) model in the proximal tibial metaphysis. CSD without treatment served as negative control. After 1 day, 6 and 12 weeks, the rabbits were euthanized, the bone were harvested and subjected for analysis. Results: Radiological images and histological sections revealed integration of implants with bone tissue with no signs of graft rejection. There was direct contact between osteopaste material and host bone. The new bone was seen bridging the defect. Conclusion: The result showed that Osteopaste could be a new promising biomaterial for bone repair and has a potential in bone tissue engineering.

Characterization and in vivo evaluation of calcium phosphate coated cp-titanium by dip-spin method

2005 ◽  
Vol 5 (5) ◽  
pp. 501-506 ◽  
Author(s):  
Changkook You ◽  
In-Sung Yeo ◽  
Myung-Duk Kim ◽  
Tae-Kwan Eom ◽  
Jae-Yeol Lee ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
In Vivo Evaluation

Development of injectable chitosan/biphasic calcium phosphate bone cement and in vitro and in vivo evaluation

2020 ◽  
Vol 15 (5) ◽  
pp. 055038
Author(s):  
Sirirat T. Rattanachan ◽  
Nuan La-ong Srakaew ◽  
Paritat Thaitalay ◽  
Oranich Thongsri ◽  
Rawee Dangviriyakul ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Biphasic Calcium Phosphate ◽  
In Vivo Evaluation ◽  
Calcium Phosphate Bone Cement

In vivo evaluation of interactions between biphasic calcium phosphate (BCP)-niobium pentoxide (Nb2O5) nanocomposite and tissues using a rat critical-size calvarial defect model

2020 ◽  
Vol 31 (8) ◽  
Author(s):  
Helio de Jesus Kiyochi Junior ◽  
Aline Gabriela Candido ◽  
Taiana Gabriela Moretti Bonadio ◽  
José Adauto da Cruz ◽  
Mauro Luciano Baesso ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Critical Size ◽  
Niobium Pentoxide ◽  
Calvarial Defect ◽  
Defect Model ◽  
In Vivo Evaluation

In vitro and in vivo evaluation of the biocompatibility of a calcium phosphate/poly(lactic-co-glycolic acid) composite

2012 ◽  
Vol 23 (7) ◽  
pp. 1785-1796 ◽  
Author(s):  
A. Gala-García ◽  
M. B. H. Carneiro ◽  
G. A. B. Silva ◽  
L. S. Ferreira ◽  
L. Q. Vieira ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Glycolic Acid ◽  
In Vivo Evaluation

scholarly journals Effect of silicon-doped calcium phosphate cement on angiogenesis based on controlled macrophage polarization

2021 ◽  
Author(s):  
Soomin Lee ◽  
Zheng Li ◽  
Dehua Meng ◽  
Qinming Fei ◽  
Libo Jiang ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Calcium Phosphate Cement ◽  
Bone Repair ◽  
Macrophage Polarization ◽  
Calvarial Bone ◽  
Inflammatory Phase ◽  
Endothelial Proliferation ◽  
Silicon Doped

Abstract Vascularization is an important early indicator of osteogenesis involving biomaterials. Bone repair and new bone formation are associated with extensive neovascularization. Silicon-based biomaterials have attracted widespread attention due to their rapid vascularization. Although calcium phosphate cement (CPC) is a mature substitute for bone, the application of CPC is limited by its slow degradation and insufficient promotion of neovascularization. Calcium silicate (CS) has been shown to stimulate vascular endothelial proliferation. Thus, CS may be added to CPC (CPC–CS) to improve the biocompatibility and neovascularization of CPC. In the early phase of bone repair (the inflammatory phase), macrophages accumulate around the biomaterial and exert both anti- and pro-inflammatory effects. However, the effect of CPC–CS on macrophage polarization is not known, and it is not clear whether the effect on neovascularization is mediated through macrophage polarization. In the present study, we explored whether silicon-mediated macrophage polarization contributes to vascularization by evaluating the CPC–CS-mediated changes in the immuno-environment under different silicate ion contents both in vivo and in vitro. We found that the silicon released from CPC–CS can promote macrophage polarization into the M2 phenotype and rapid endothelial neovascularization during bone repair. Dramatic neovascularization and osteogenesis were observed in mouse calvarial bone defects implanted with CPC–CS containing 60% CS. These findings suggest that CPC–CS is a novel biomaterial that can modulate immune response, promote endothelial proliferation, and facilitate neovascularization and osteogenesis. Thus, CPC–CS shows potential as a bone substitute material.

scholarly journals Enhanced release of calcium phosphate additives from bioresorbable orthopaedic devices using irradiation technology is non-beneficial in a rabbit model

2019 ◽  
Vol 8 (6) ◽  
pp. 266-274
Author(s):  
I. Palmer ◽  
S. A. Clarke ◽  
F. J Buchanan
Keyword(s):  
Calcium Phosphate ◽  
Bone Repair ◽  
Bone Growth ◽  
Calcium Release ◽  
Release Kinetics ◽  
Rabbit Model ◽  
Tissue Response ◽  
Ph Change ◽  
Irradiation Technology

Objectives Bioresorbable orthopaedic devices with calcium phosphate (CaP) fillers are commercially available on the assumption that increased calcium (Ca) locally drives new bone formation, but the clinical benefits are unknown. Electron beam (EB) irradiation of polymer devices has been shown to enhance the release of Ca. The aims of this study were to: 1) establish the biological safety of EB surface-modified bioresorbable devices; 2) test the release kinetics of CaP from a polymer device; and 3) establish any subsequent beneficial effects on bone repair in vivo. Methods ActivaScrew Interference (Bioretec Ltd, Tampere, Finland) and poly(L-lactide-co-glycolide) (PLGA) orthopaedic screws containing 10 wt% β-tricalcium phosphate (β-TCP) underwent EB treatment. In vitro degradation over 36 weeks was investigated by recording mass loss, pH change, and Ca release. Implant performance was investigated in vivo over 36 weeks using a lapine femoral condyle model. Bone growth and osteoclast activity were assessed by histology and enzyme histochemistry. Results Calcium release doubled in the EB-treated group before returning to a level seen in untreated samples at 28 weeks. Extensive bone growth was observed around the perimeter of all implant types, along with limited osteoclastic activity. No statistically significant differences between comparative groups was identified. Conclusion The higher than normal dose of EB used for surface modification did not adversely affect tissue response around implants in vivo. Surprisingly, incorporation of β-TCP and the subsequent accelerated release of Ca had no significant effect on in vivo implant performance, calling into question the clinical evidence base for these commercially available devices. Cite this article: I. Palmer, S. A. Clarke, F. J Buchanan. Enhanced release of calcium phosphate additives from bioresorbable orthopaedic devices using irradiation technology is non-beneficial in a rabbit model: An animal study. Bone Joint Res 2019;8:266–274. DOI: 10.1302/2046-3758.86.BJR-2018-0224.R2.

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