Reconstruction of mandibular bone defects using biphasic calcium phosphate bone substitutes with simultaneous implant placement in mini‐swine: A pilot in vivo study

2018 ◽  
Vol 107 (6) ◽  
pp. 2071-2079 ◽  
Author(s):  
Zhen Zhang ◽  
Peng Wang ◽  
Xiang Li ◽  
Yu Wang ◽  
Zhifan Qin ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Bone Substitutes ◽  
Bone Defects ◽  
In Vivo Study ◽  
Mandibular Bone ◽  
Implant Placement

scholarly journals Biphasic Calcium Phosphate Bioceramics for Orthopaedic Reconstructions: Clinical Outcomes

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Carlos A. Garrido ◽  
Sonja E. Lobo ◽  
Flávio M. Turíbio ◽  
Racquel Z. LeGeros
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Clinical Outcomes ◽  
Biphasic Calcium Phosphate ◽  
Excellent Result ◽  
Bone Substitutes ◽  
Bone Defects ◽  
Clinical Parameters ◽  
Bone Reconstruction

BCP are considered the most promising biomaterials for bone reconstruction. This study aims at analyzing the outcomes of patients who received BCP as bone substitutes in orthopaedic surgeries. Sixty-six patients were categorized according to the etiology and morphology of the bone defects and received scores after clinical and radiographic evaluations. The final results corresponded to the combination of both parameters and varied from 5 (excellent result) to 2 or lower (poor result). Most of the patients who presented cavitary defects or bone losses due to prosthesis placement or revision, osteotomies, or arthrodesis showed good results, and some of them excellent results. However, patients with segmental defects equal or larger than 3 cm in length were classified as moderate results. This study established clinical parameters where the BCP alone can successfully support the osteogenic process and where the association with other tissue engineering strategies may be considered.

Biphasic calcium phosphate to repair nasal septum: The first in vitro and in vivo study

2010 ◽  
Vol 6 (3) ◽  
pp. 909-919 ◽  
Author(s):  
Ludovic de Gabory ◽  
Reine Bareille ◽  
Dominique Stoll ◽  
Laurence Bordenave ◽  
Jean-Christophe Fricain
Keyword(s):  
Calcium Phosphate ◽  
Nasal Septum ◽  
Biphasic Calcium Phosphate ◽  
In Vivo Study

Impact of Biphasic Calcium Phosphate Bioceramics on Osteoporotic Hip Bone Mineralization In Vivo Six Months after Implantation

2016 ◽  
Vol 721 ◽  
pp. 229-233 ◽  
Author(s):  
Sandris Petronis ◽  
Janis Locs ◽  
Vita Zalite ◽  
Mara Pilmane ◽  
Andrejs Skagers ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Bone Mineralization ◽  
Bone Substitutes ◽  
Tissue Response ◽  
Control Group ◽  
Osteoporotic Bone ◽  
Local Recovery

Calcium bone substitutes are successfully used for local recovery of osteoporotic bone and filling of bone defects. Previous studies revieled that biphasic calcium phosphate (BCP) show better bioactivity in compare to pure β-tricalcium phosphate or hydroxyapatite. Also increased porosity of material promotes better bone tissue response. Aim of this experiment was to evaluate immunohistologically response of osteoporotic bone of experimental animal to implantation of granules with hydroxyapatite/β-tricalcium phosphate (HAp/β-TCP) ratio of 90/10. Calcium phosphate (CaP) was synthesized by aqueous precipitation technique from calcium hydroxide and phosphoric acid. Bioceramic granules in size range from 1.0 to 1.4 mm were prepared with nanopore sizes around 200 nm. We used nine female rabbits with induced osteoporosis in this experiment. Six animals in study group underwent implantation of BCP in hip bone defect and three animals in control group left without BCP implantation. After 6 months animals were euthanized, bone samples collected and proceeded for detection of bone activity and repair markers: osteocalcin (OC), osteopontin (OP) and osteoprotegerin (OPG). Controls showed the presence of experimental bone osteoporosis. In experimental group bone showed partially resorbed bioceramic granules and in some samples new bone formation near the granuli was observed. Increase of OC and OPG up to twice as to compare to control group were detected as well. Implantation of BCP granules in osteoporotic rabbit bone increases expression of OC and OPG indicating the activation of osteoblastogenesis and bone mineralization in vivo.

scholarly journals In vivo evaluation of poorly crystalline hydroxyapatite-based biphasic calcium phosphate bone substitutes for treating dental bony defects

2010 ◽  
Vol 5 (2) ◽  
pp. 100-108 ◽  
Author(s):  
Mao-Shuan Huang ◽  
Hong-Da Wu ◽  
Nai-Chia Teng ◽  
Bou-Yue Peng ◽  
Jia-Yo Wu ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Bone Substitutes ◽  
In Vivo Evaluation

scholarly journals A Combination of Biphasic Calcium Phosphate (Maxresorb®) and Hyaluronic Acid Gel (Hyadent®) for Repairing Osseous Defects in a Rat Model

2020 ◽  
Vol 10 (5) ◽  
pp. 1651 ◽  
Author(s):  
Abeer G. Ahmed ◽  
Fatin A. Awartani ◽  
Abdurahman A. Niazy ◽  
John A. Jansen ◽  
Hamdan S. Alghamdi
Keyword(s):  
Hyaluronic Acid ◽  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Rat Model ◽  
Biphasic Calcium Phosphate ◽  
Bone Defects ◽  
Group I ◽  
Male Wistar Rats ◽  
Osseous Defects

The aim of this in vivo study was to evaluate the efficacy of biphasic calcium phosphate (Maxresorb®, BCP) used in combination with hyaluronic acid (Hyadent®, HyA) gel for regeneration of osseous defects in a rat model. Bilateral femoral condylar bone defects (3 mm diameter and 3 mm depth) were created in 40 male Wistar rats. The defects were grafted as group I (BCP only), group II (BCP + HyA), group III (HyA only), and group IV (empty control). At four weeks and 10 weeks, the bone specimens were evaluated using histological and histomorphometrical analyses to identify the newly formed bone area (NF-BA (%)), as well as the remaining BCP particles (R-BCP (%)). Light microscopic examination indicated the absence of an inflammatory reaction within the bone defects after four weeks or 10 weeks of implantation. Significant new bone regeneration was present in the bone defects grafted with BCP or BCP + HyA biomaterials, as early as four weeks, compared to control groups. The addition of HyA to BCP did not significantly improve bone regeneration at four weeks or 10 weeks. Nevertheless, its role in bone healing and regeneration warrants further investigation.

In Vivo Demonstration of 2 Types of Microporosity on the Kinetic of Bone Ingrowth and Biphasic Calcium Phosphate Bioceramics Resorption

2007 ◽  
Vol 361-363 ◽  
pp. 1233-1236 ◽  
Author(s):  
Oliver Malard ◽  
Helene Gautier ◽  
G. Daculsi
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Critical Size ◽  
Bone Ingrowth ◽  
Bone Substitutes ◽  
High Porosity ◽  
Critical Size Defects ◽  
Significant Difference ◽  
Kinetics Of

Microporosity and granules size are important parameters for the development of suspension, composites and injectable bone substitutes. In this experimental study performed in a rat bone model of critical size defects, were have determined the kinetics of bioceramic resorption and bone ingrowth. Two kinds of granules (1mm in diameter) of Biphasic Calcium Phosphate BCP (60/40 HA/TCP ratio) with 20% and 40% microporosity of less of 5 microns in size, were used. Higher bone ingrowth was observed for low porosity (LP) at 3 weeks versus high porosity (HP); the contrary was measured after 6 weeks. About the kinetics of BCP resorption, significant difference between the 2 porosities was noticed, the higher for high microporosity. High porosity on time, promotes more bone ingrowth at the expense of the bioceramic than lower microporosity.

scholarly journals In Vitro and In Vivo Evaluation of Nanostructured Biphasic Calcium Phosphate in Granules and Putty Configurations

2021 ◽  
Vol 18 (2) ◽  
pp. 533
Author(s):  
Jhonathan R. B. Nascimento ◽  
Suelen C. Sartoretto ◽  
Adriana T. N. N. Alves ◽  
Carlos F. A. B. Mourão ◽  
Victor R. Martinez-Zelaya ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Wistar Rats ◽  
Biphasic Calcium Phosphate ◽  
Biological Response ◽  
Bone Defects ◽  
Fibroblast Cells ◽  
In Vivo Evaluation ◽  
Histological Results

Synthetic biphasic calcium phosphate (BCP) granules and powder are biocompatible biomaterials with a well-known capacity for osteoconduction, presenting very satisfactory clinical and histological results. It remains unanswered if the putty configuration impacts the biological response to the material. In this study, we aimed to compare the cytocompatibility and biocompatibility of nanostructured BCP in the putty configuration (moldable nanostructured calcium phosphate, MnCaP) on the healing of critical-sized bone defects (8 mm) in rat calvaria. Cytocompatibility was determined through the viability of fibroblast cells (V-79) to the extracts of different concentrations of MnCaP. Forty-five Wistar rats were randomly divided into three groups (n = 15)—clot, MnCaP, and commercial biphasic calcium phosphate in granules configurations (Nanosynt®)—and subdivided into three experimental periods (1, 3, and 6 months). Histological, histomorphometric, and microtomographic analyses allowed the evaluation of newly formed bone, residual biomaterial, and connective tissue. The in vitro evaluation showed that MnCaP was cytocompatible. The histomorphometric results showed that the Nanosynt® group granted the highest new-formed bone values at six months (p < 0.05), although the biomaterial volume did not differ between groups. The putty configuration was easier to handle, and both configurations were biocompatible and osteoconductive, presented similar biosorption rates, and preserved the calvaria architecture.

scholarly journals Biological behavior of 60/40 biphasic calcium phosphate and growth hormone mixture: in vivo study in dogs

2019 ◽  
Vol 65 (1) ◽  
pp. 179-188
Author(s):  
Lama El Marsafy ◽  
Rania EI behairy ◽  
Ibrahim Ahmed ◽  
Monazah Khafagi
Keyword(s):  
Growth Hormone ◽  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
In Vivo Study ◽  
Biological Behavior
Sign in / Sign up

Export Citation Format

Share Document