Bone healing around nanocrystalline hydroxyapatite, deproteinized bovine bone mineral, biphasic calcium phosphate, and autogenous bone in mandibular bone defects

2014 ◽  
Vol 103 (7) ◽  
pp. 1478-1487 ◽  
Author(s):  
Nina Broggini ◽  
Dieter D. Bosshardt ◽  
Simon S. Jensen ◽  
Michael M. Bornstein ◽  
Chun-Cheng Wang ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Bone Defects ◽  
Autogenous Bone ◽  
Bovine Bone ◽  
Mandibular Bone ◽  
Nanocrystalline Hydroxyapatite ◽  
Bovine Bone Mineral ◽  
Deproteinized Bovine Bone Mineral ◽  
Deproteinized Bovine Bone

scholarly journals Bone Formation with Deproteinized Bovine Bone Mineral or Biphasic Calcium Phosphate in the Presence of Autologous Platelet Lysate: Comparative Investigation in Rabbit

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Carole Chakar ◽  
Nada Naaman ◽  
Emmanuel Soffer ◽  
Nicolas Cohen ◽  
Nada El Osta ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Bone Substitutes ◽  
Platelet Lysate ◽  
Bovine Bone ◽  
Residual Material ◽  
Bovine Bone Mineral ◽  
Deproteinized Bovine Bone Mineral ◽  
Autologous Platelet ◽  
Deproteinized Bovine Bone

Bone substitutes alone or supplemented with platelet-derived concentrates are widely used to promote bone regeneration but their potency remains controversial. The aim of this study was, therefore, to compare the regenerative potential of preparations containing autologous platelet lysate (APL) and particles of either deproteinized bovine bone mineral (DBBM) or biphasic calcium phosphate (BCP), two bone substitutes with different resorption patterns. Rabbit APL was prepared by freeze-thawing a platelet suspension. Critical-size defects in rabbit femoral condyle were filled with DBBM or DBBM+APL and BCP or BCP+APL. Rabbits were sacrificed after six weeks and newly formed bone and residual implanted material were evaluated using nondemineralized histology and histomorphometry. New bone was observed around particles of all fillers tested. In the defects filled with BCP, the newly formed bone area was greater (70%;P<0.001) while the residual material area was lower (60%;P<0.001) than that observed in those filled with DBBM. New bone and residual material area of defects filled with either APL+DBBM or APL+BCP were similar to those observed in those filled with the material alone. In summary, osteoconductivity and resorption of BCP were greater than those of DBBM, while APL associated with either DBBM or BCP did not have an additional benefit.

scholarly journals Histological Comparison between Biphasic Calcium Phosphate and Deproteinized Bovine Bone on Critical-Size Bone Defects

2021 ◽  
Vol 32 (1) ◽  
pp. 26-33
Author(s):  
Marina Araujo Brito ◽  
Leomar Emanuel Almeida Mecca ◽  
Thais dos Santos Sedoski ◽  
Tayline Mroczek ◽  
Marcela Claudino ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Tissue ◽  
Biphasic Calcium Phosphate ◽  
Bone Repair ◽  
Critical Size ◽  
Blood Clot ◽  
Bone Defects ◽  
Bovine Bone ◽  
Tissue Area ◽  
Deproteinized Bovine Bone

Abstract The limited options for bone repair have led to an extensive research of the field and the development of alloplastic and xenogeneic grafts. The purpose of this study was to evaluate bone repair with two bone substitutes: deproteinized bovine bone (DBB) and biphasic calcium phosphate ceramic (BCP) in critical-size defect. A total of 8-mm defects were made in the parietal bones of rabbits (n=12). The animals were divided into three experimental groups: sham (defect filled with a blood clot), DBB (defect filled with DBB), and BCP (defect filled with BCP). After the experimental periods of 15 and 45 days, the animals were euthanized and submitted to histomorphometric analysis. The total defect area, mineralized tissue area, biomaterial area, and soft tissue area were evaluated. A greater amount of immature bone tissue and biomaterial particles were observed in the BCP group compared to DBB and sham at 45 days (p<0.05). There was no difference in the qualitative pattern of bone deposition between DBB and BCP. However, the sham group did not show osteoid islands along with the defect, presenting a greater amount of collagen fibers as well in relation to the DBB and BCP groups. There was a greater number of inflammatory cells in the DBB at 45 days compared to BCP and sham groups. In conclusion, BCP and DBB are options for optimizing the use of bone grafts for maxillofacial rehabilitation. Bone defects treated with BCP showed greater deposition of bone tissue at 45 days.

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