Novel tricalcium silicate/monocalcium phosphate monohydrate composite bone cement

2007 ◽  
Vol 82B (2) ◽  
pp. 352-359 ◽  
Author(s):  
Zhiguang Huan ◽  
Jiang Chang
2011 ◽  
Vol 100B (1) ◽  
pp. 94-102 ◽  
Author(s):  
Loreley Morejón-Alonso ◽  
Oscar Jacinto Bareiro Ferreira ◽  
Raúl Garcia Carrodeguas ◽  
Luis Alberto dos Santos

2015 ◽  
Vol 18 (1) ◽  
pp. 164-169 ◽  
Author(s):  
Loreley Morejón-Alonso ◽  
Mariana Motisuke ◽  
José Raúl Correa ◽  
Raúl García Carrodeguas ◽  
Luis Alberto dos Santos

2021 ◽  
pp. 088532822110203
Author(s):  
Rongguang Zhang ◽  
Jinbo Hu ◽  
Hong Chen ◽  
Zhengwen Ding ◽  
Yalan Ouyang ◽  
...  

In this study, tricalcium silicate (C3S) calcium/polyphosphate/polyvinyl alcohol organic-inorganic self-setting composites were successfully designed. A variety of tests were conducted to characterize their self-setting properties, mechanical properties, degradation properties, and related biological properties. The composite bone cements showed a short setting time (5.5–37.5 min) with a 5:5–6:4 ratio of C3S/CPP to maintain a stable compressive strength (28 MPa). In addition, PVA effectively reduced the brittleness of the inorganic phase. Degradation experiments confirmed the sustainable surface degradation of bone cement. A maximum degradation rate of 49% was reached within 56 days, and the structure remained intact without collapse. Culturing MC3T3 cells with bone cement extracts revealed that the composite bone cements had excellent biological properties in vitro. The original extract showed a proliferation promotion effect on cells, whereas most of the other original extracts of degradable bone cements were toxic to the cells. Meanwhile, extracellular matrix mineralization and alkaline phosphatase expression showed remarkable effects on cell differentiation. In addition, a good level of adhesion of cells to the surfaces of materials was observed. Taken together, these results indicate that C3S/CPP/PVA composite bone cements have great potential in bone defect filling for fast curing.


2021 ◽  
Vol 150 ◽  
pp. 109825
Author(s):  
Zhengwen Ding ◽  
Wenjing Xi ◽  
Mizhi Ji ◽  
Xiaodan Li ◽  
Qiyi Zhang ◽  
...  

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