Prevention of abdominal adhesion formation by thermosensitive PECE-hydrogel in a rat uterine horn model

2010 ◽  
Vol 96B (1) ◽  
pp. 57-66 ◽  
Author(s):  
Bing Yang ◽  
Chang Yang Gong ◽  
Zhi Yong Qian ◽  
Xia Zhao ◽  
Zheng Yu Li ◽  
...  
Keyword(s):  
Adhesion Formation ◽  
Uterine Horn ◽  
Abdominal Adhesion

scholarly journals The effect of rosiglitazone in the prevention of intra-abdominal adhesion formation in a rat uterine horn model

2006 ◽  
Vol 21 (11) ◽  
pp. 3008-3013 ◽  
Author(s):  
F. Demirturk ◽  
H. Aytan ◽  
A. Caliskan ◽  
P. Aytan ◽  
T. Yener ◽  
...  
Keyword(s):  
Adhesion Formation ◽  
Uterine Horn ◽  
Abdominal Adhesion

The Effect of Disulfiram in the Prevention of Postoperative Adhesion Formation in an Experimental Rat Uterine Horn Model

2021 ◽  
Author(s):  
Yıldız Akdaş Reis ◽  
Omer Lutfi Tapisiz ◽  
Ümit Göktolga ◽  
Gülçin Şimşek ◽  
Özlem Erten ◽  
...  
Keyword(s):  
Adhesion Formation ◽  
Uterine Horn ◽  
Postoperative Adhesion

Honokiol Decreases Intra-Abdominal Adhesion Formation in a Rat Model

2015 ◽  
Vol 79 (3) ◽  
pp. 160-167 ◽  
Author(s):  
Elif Agacayak ◽  
Senem Yaman Tunc ◽  
Mehmet Sait Icen ◽  
Ulas Alabalik ◽  
Fatih Mehmet Findik ◽  
...  
Keyword(s):  
Rat Model ◽  
Adhesion Formation ◽  
Abdominal Adhesion

scholarly journals TMIGD1 Inhibited Abdominal Adhesion Formation by Alleviating Oxidative Stress in the Mitochondria of Peritoneal Mesothelial Cells

2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Yunhua Wu ◽  
Enmeng Li ◽  
Zijun Wang ◽  
Tianli Shen ◽  
Cong Shen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Function ◽  
Adhesion Formation ◽  
Mesothelial Cell ◽  
Mesothelial Cells ◽  
Stress Injury ◽  
Peritoneal Mesothelial Cells ◽  
Abdominal Adhesion ◽  
Adhesion Tissue ◽  
Peritoneal Mesothelial Cell

Background. Postoperative abdominal adhesion remains one of the frequent complications after abdominal surgery and lacks effective intervention. Peritoneal mesothelial cell injury and healing play crucial roles in the process of adhesion formation, and identifying this mechanism might provide new insight into possible new therapeutic strategies for this disease. Transmembrane and immunoglobulin domain-containing 1 (TMIGD1) has been proven to protect renal epithelial cells from injury induced by oxidative stress and has also been identified as a novel adhesion molecule. Here, we investigated the role of TMIGD1 and its possible mechanism in adhesion formation. Materials and Methods. Immunohistochemistry (IHC), qPCR, and immunofluorescence (IHF) were used to detect the expression of TMIGD1. The grade and tenacity score of adhesion were used to evaluate the adhesion formation conditions. A TMIGD1-overexpressing HMrSV5 cell line was established. MTT assay, Western blotting, Annexin V apoptosis analysis, and CK19 staining were used to measure mesothelial cell viability, apoptosis, and completeness. ROS and MDA detection were used to measure mesothelial cell oxidative stress levels. JC-1 staining, IHF, and transmission electron microscopy were performed to assess mitochondrial function. Scratch-wound and adhesion assays were used to evaluate the adhesion ability of mesothelial cells. Results. First, we showed that TMIGD1 was decreased in mouse abdominal adhesion tissue and peritoneal mesothelial cells. Second, TMIGD1 overexpression inhibited adhesion formation. Third, TMIGD1 overexpression protected mesothelial cells from hydrogen peroxide- (H2O2-) induced oxidative stress injury. Fourth, TMIGD1 overexpression alleviated oxidative stress by protecting the mitochondrial function of mesothelial cells. In addition, TMIGD1 overexpression enhanced mesothelial cell adhesion. Conclusion. Our findings suggest that TMIGD1 protects mesothelial cells from oxidative stress injury by protecting their mitochondrial function, which is decreased in regular abdominal adhesion tissue. In addition, TMIGD1 enhances peritoneal mesothelial cell adhesion to promote healing.

A Trial of Reducing Adhesion Formation in a Uterine Horn Model

1998 ◽  
Vol 45 (1) ◽  
pp. 58-61 ◽  
Author(s):  
Birol Vural ◽  
Ramazan Mercan ◽  
Aydın Çorakçı ◽  
Semih Özeren ◽  
Nadi Keskin ◽  
...  
Keyword(s):  
Adhesion Formation ◽  
Uterine Horn

scholarly journals The comparison of methylene blue and vitamin E in prevention of abdominal postoperative adhesion formation in rat uterine horn models: Biochemical and histopathologic evaluation

2011 ◽  
Vol 26 (1) ◽  
pp. 51-57 ◽  
Author(s):  
Hamit Yildiz ◽  
Ali Said Durmus ◽  
Halil Simsek ◽  
Ihsan Yaman
Keyword(s):  
Vitamin E ◽  
Saline Solution ◽  
Adhesion Formation ◽  
Uterine Horn ◽  
Postoperative Adhesion ◽  
Mononuclear Cell Infiltration ◽  
The Third ◽  
Methylen Blue ◽  
Histopathologic Evaluation ◽  
Adhesion Model

Purpose: To compare the effects of vitamin E and 1% methylen blue solutions on prevention of experimentally induced adhesions in rats. Methods: Thirty seven female Spraque Dawley rats were randomized into four groups. First group was kept as sham operated group. An adhesion model was constituted on the left uterine horn of the other groups. The lesion areas of rats from the second, the third and the fourth groups were coated with 2 ml 0.9 % saline solution (C group), 10 mg vitamin E (VE group) and 1% methylen blue solutions (MB group), respectively. Results: Histopathologically, adhesion scores, mononuclear cell infiltration, oedema and fibrosis were more prominent in the MB group compared with C and VE groups. There were no significant differences between the groups in tissue glutathione peroxidase (GPx), catalase (CAT) activities and glutation (GSH) level, these parameters were slightly increased in group with VE supplementation though. The administration of VE and MB significantly decreased NO (P<0.01) levels when compared to the C group. The level of malondialdehyde (MDA) in the VE group was significantly lower (P<0.05) than those of the Sh and C groups. Conclusion: Intraperitoneal methylen blue solutions treatments were more effective according to vitamin E in preventing the formation of intra-abdominal adhesion in a rat uterine horn model.

Adhesion formation after uterine horn resection in rabbit model: comparative study of laparoscopic procedure vs. laparotomy

2002 ◽  
Vol 11 (6) ◽  
pp. 365-369 ◽  
Author(s):  
Iuri Donati Telles de Sousa ◽  
Francisco José Candido dos Reis ◽  
Sérgio Brito Garcia ◽  
Antonio Alberto Nogueira
Keyword(s):  
Comparative Study ◽  
Adhesion Formation ◽  
Rabbit Model ◽  
Uterine Horn ◽  
Laparoscopic Procedure
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