scholarly journals Lung inflammation caused by long-term exposure to titanium dioxide in mice involving in NF-κB signaling pathway

2017 ◽  
Vol 105 (11) ◽  
pp. 3224-3224
Keyword(s):  
Titanium Dioxide ◽  
Signaling Pathway ◽  
Lung Inflammation

Liver Inflammation and Fibrosis Induced by Long-Term Exposure to Nano Titanium Dioxide (TiO2) Nanoparticles in Mice and Its Molecular Mechanism

2020 ◽  
Vol 16 (5) ◽  
pp. 616-625
Author(s):  
Fashui Hong ◽  
Jianhui Ji ◽  
Xiao Ze ◽  
Yingjun Zhou ◽  
Yuguan Ze
Keyword(s):  
Titanium Dioxide ◽  
Liver Fibrosis ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Hepatic Fibrosis ◽  
Wnt Signaling Pathway ◽  
Underlying Mechanism ◽  
The Body ◽  
Fibrotic Liver

Titanium dioxide (TiO2) and nano-sized titanium dioxide (nano-TiO2), which are used in food production, may be harmful to the body. Long-term exposure to nano-TiO2 can lead to hepatic injury; however, the effect of nano-TiO2 on liver fibrosis and the underlying mechanism remain unclear. The TGF-β/Smad/MAPK/Wnt signaling pathway is important for tissue fibrosis. In this study, mice were fed nano-TiO2 (2.5, 5, and 10 mg/kg body weight) for nine consecutive months to investigate its effect on liver fibrosis. Nano-TiO2 induced hepatic inflammatory cell infiltration and hepatic fibrosis and upregulated the expression of HIF-1α (+75-fold to +2.38-fold), Wnt3 (+12% to +135%), Wnt4 (1.33-fold to 6-fold), NF-κB (+3.13% to +34.38%), TGF-β1 (+1307-fold to +1.85-fold), TGF-β1R (+0.8-fold to 1.33-fold), Smad-2 (+0.58-fold to +1.58-fold), ILK (+0.43-fold to +1.19-fold), ECM (+1.82-fold to 2.36-fold), calpain 2 (+0.11-fold to +0.78-fold), α-SMA (+0.63-fold to +1.56-fold), c-Myc (+0.27-fold to +0.46-fold), and collagen I (+8% to +36%), and increased the phosphorylation level of p38MAPK (+66.67% to +153.33%) in inflammatory and fibrotic liver tissues, whereas it downregulated cyclin D (–6.25% to –43.75%) and decreased the phosphorylation levels of GSK-3β (–3.12% to –46.88%) and β-catenin (–19.57% to –45.65%). These results indicate that hepatic fibrosis induced by nano-TiO2 is mediated by the TGF-β/Smads/MAPK/Wnt signaling pathway. This study provides insight into the mechanism underlying hepatic toxicity induced by nano-TiO2 .

scholarly journals Photocatalytic Activity Enhancement of Low-pressure Cold-Sprayed TiO2 Coatings Induced by Long-term Water Vapor Exposure

2021 ◽  
Author(s):  
Seremak Wioletta ◽  
Baszczuk Agnieszka ◽  
Jasiorski Marek ◽  
Gibas Anna ◽  
Winnicki Marcin
Keyword(s):  
Titanium Dioxide ◽  
Photocatalytic Activity ◽  
Water Vapor ◽  
Sol Gel ◽  
Low Pressure ◽  
Oxygen Depletion ◽  
Amorphous Structure ◽  
Industrial Applications ◽  
Additional Parameter

AbstractThis work shows that the titanium dioxide coatings obtained by low-pressure cold gas spraying with the use of the sol–gel amorphous TiO2 powder are characterized by photocatalytic activity despite their partial amorphous content. Moreover, the research outcome suggests that the decomposition rate of organic pollutants is enhanced after long-term exposure to moisture. The condensation humidity test is not detrimental to the continuity and integrity of the coating, but the phase composition of coatings changes—with the exposure to water vapor, the portion of the amorphous phase crystallizes into brookite. The mechanism responsible for the conversion of amorphous TiO2 into brookite is attributed to the water-driven dissolution and reprecipitation of TiO6 octahedra. It has been shown that an additional parameter necessary for the stabilization of the brookite is the oxygen depletion of the amorphous structure of titanium dioxide. Considering the results presented in this paper and the advantages of a portable, low-pressure cold spray system for industrial applications, it is expected that TiO2 coatings produced from a sol–gel feedstock powder can be further developed and tested as efficient photocatalysts.

scholarly journals PO-103 The mechanism of long-term regular exercise intervention on liver injury in patients with NAFLD based on miR-146a regulation of TLR4/NF-KB signaling pathway

2018 ◽  
Vol 1 (4) ◽  
Author(s):  
Qi Peng ◽  
Jiaqin Chen ◽  
Wei Chen ◽  
Chang Feng Shao ◽  
Afang Yuan
Keyword(s):  
Liver Fibrosis ◽  
Liver Injury ◽  
Fatty Liver ◽  
Signaling Pathway ◽  
Exercise Intervention ◽  
Exercise Group ◽  
Control Group ◽  
Regular Exercise ◽  
Alcoholic Fatty Liver

Objective To investigate the effects of long-term regular exercise on hepatic function in patients with non-alcoholic fatty liver (NAFLD) using blood biochemistry and liver fibrosis markers, and to compare the differential expression of cytokines related to TLR4/NF-KB signaling pathway. A preliminary discussion was made on its regulation mechanism. Methods Forty patients with NAFLD diagnosed in the Hunan Normal University School of Medicine, according to the degree of steatosis and exercise intervention, the patients were divided into control group (NAFLD group) 20 cases and long-term regular exercise group 20 cases, and the same time in our hospital Twenty patients with physical examination were normal controls; general data of all subjects, ALT, AST, GGT, serum type III procollagen (PCIII), hyaluronan (HA), and type IV collagen (CIV) were examined; Fluorescent quantitative PCR was used to detect the differential expression of TLR4/NF-KB signaling pathway-related cytokines and miR-146a in the blood of each group of subjects, revealing the effects and possible mechanisms of long-term regular exercise on liver fibrosis. Results Compared with the normal group, the levels of serum ALT, AST, GGT, PCIII, HA, and CIV in the non-alcoholic fatty liver patients were significantly lower in the long-term regular exercise group than in the control group; blood TLR4, NF-KB, MY-D88 Compared with the control group, the gene expression level was significantly downregulated in the long-term regular exercise group.  Conclusions Long-term regular exercise can effectively reduce nonalcoholic inflammatory liver injury and has a clear anti-fibrotic effect. Its mechanism may be related to long-term regular exercise through regulating the TLR4/NF-KB signaling pathway related factors and the regulation of molecular miR-146a, reducing inflammation and preventing the formation of fibrosis.

scholarly journals Effects of Maternal Chromium Restriction on the Long-Term Programming in MAPK Signaling Pathway of Lipid Metabolism in Mice

Nutrients ◽  
2016 ◽  
Vol 8 (8) ◽  
pp. 488 ◽  
Author(s):  
Qian Zhang ◽  
Xiaofang Sun ◽  
Xinhua Xiao ◽  
Jia Zheng ◽  
Ming Li ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Signaling Pathway ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway
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