scholarly journals Chelerythrine Attenuates the Inflammation of Lipopolysaccharide-Induced Acute Lung Inflammation Through NF-κB Signaling Pathway Mediated by Nrf2

2018 ◽  
Vol 9 ◽  
Author(s):  
Lu Fan ◽  
Ye Fan ◽  
Li Liu ◽  
Weiwei Tao ◽  
Xin Shan ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Lung Inflammation ◽  
Acute Lung Inflammation

TLR4-MyD88 signaling pathway is responsible for acute lung inflammation induced by reclaimed water

2020 ◽  
Vol 396 ◽  
pp. 122586 ◽  
Author(s):  
Gang Liu ◽  
Yun Lu ◽  
Liangliang Shi ◽  
Yunru Ren ◽  
Jiayang Kong ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Lung Inflammation ◽  
Reclaimed Water ◽  
Acute Lung Inflammation ◽  
Myd88 Signaling

scholarly journals Activation of NF-κB signaling in rare earth neodymium oxide particle-induced acute lung injury

2015 ◽  
Vol 4 (6) ◽  
pp. 1587-1596 ◽  
Author(s):  
Suhua Wang ◽  
Yanrong Gao ◽  
Lihua Huang ◽  
Shanshan Zheng ◽  
Chunxia Wang ◽  
...  
Keyword(s):  
Rare Earth ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Signaling Pathway ◽  
Lung Inflammation ◽  
Oxide Particle ◽  
Neodymium Oxide ◽  
Activation Mechanism ◽  
Acute Lung Inflammation

The activation mechanism of the NF-κB signaling pathway in Nd2O3exposure-induced acute lung inflammation and pneumoconiosis.

scholarly journals Combined In Vitro and In Vivo Approaches to Propose a Putative Adverse Outcome Pathway for Acute Lung Inflammation Induced by Nanoparticles: A Study on Carbon Dots

Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 180
Author(s):  
Maud Weiss ◽  
Jiahui Fan ◽  
Mickaël Claudel ◽  
Luc Lebeau ◽  
Françoise Pons ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Lung Inflammation ◽  
Adverse Outcome ◽  
Cellular Responses ◽  
Target Cells ◽  
Inflammasome Activation ◽  
Adverse Outcome Pathway ◽  
Acute Lung Inflammation

With the growth of nanotechnologies, concerns raised regarding the potential adverse effects of nanoparticles (NPs), especially on the respiratory tract. Adverse outcome pathways (AOP) have become recently the subject of intensive studies in order to get a better understanding of the mechanisms of NP toxicity, and hence hopefully predict the health risks associated with NP exposure. Herein, we propose a putative AOP for the lung toxicity of NPs using emerging nanomaterials called carbon dots (CDs), and in vivo and in vitro experimental approaches. We first investigated the effect of a single administration of CDs on mouse airways. We showed that CDs induce an acute lung inflammation and identified airway macrophages as target cells of CDs. Then, we studied the cellular responses induced by CDs in an in vitro model of macrophages. We observed that CDs are internalized by these cells (molecular initial event) and induce a series of key events, including loss of lysosomal integrity and mitochondrial disruption (organelle responses), as well as oxidative stress, inflammasome activation, inflammatory cytokine upregulation and macrophage death (cellular responses). All these effects triggering lung inflammation as tissular response may lead to acute lung injury.

scholarly journals Blockade of Secondary Lymphoid Tissue Chemokine ExacerbatesPropionibacterium acnes-Induced Acute Lung Inflammation

2001 ◽  
Vol 166 (3) ◽  
pp. 2071-2079 ◽  
Author(s):  
Meiji Itakura ◽  
Atsuko Tokuda ◽  
Hiroshi Kimura ◽  
Shigenori Nagai ◽  
Hiroyuki Yoneyama ◽  
...  
Keyword(s):  
Lymphoid Tissue ◽  
Lung Inflammation ◽  
Acute Lung Inflammation ◽  
Secondary Lymphoid Tissue

scholarly journals Pulmonary Endothelial Protein Kinase C-Delta (PKCδ) Regulates Neutrophil Migration in Acute Lung Inflammation

2014 ◽  
Vol 184 (1) ◽  
pp. 200-213 ◽  
Author(s):  
Mark J. Mondrinos ◽  
Ting Zhang ◽  
Shuang Sun ◽  
Paul A. Kennedy ◽  
Devon J. King ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Lung Inflammation ◽  
Neutrophil Migration ◽  
Acute Lung Inflammation ◽  
Protein Kinase C Delta ◽  
Kinase C

scholarly journals Early Detection of Susceptibility to Acute Lung Inflammation by Molecular Imaging in Mice Exposed to Cigarette Smoke

2011 ◽  
Vol 10 (5) ◽  
pp. 7290.2011.00010 ◽  
Author(s):  
Sandra Pérez-Rial ◽  
Laura del Puerto-Nevado ◽  
Nicolás González-Mangado ◽  
Germán Peces-Barba
Keyword(s):  
Molecular Imaging ◽  
Early Detection ◽  
Cigarette Smoke ◽  
Lung Inflammation ◽  
Acute Lung Inflammation

scholarly journals Induction of acute lung inflammation in mice with hemorrhagic shock and resuscitation: role of HMGB1

2014 ◽  
Vol 11 (1) ◽  
Author(s):  
Raymond LC Kao ◽  
Xuemei Xu ◽  
Anargyros Xenocostas ◽  
Neil Parry ◽  
Tina Mele ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Lung Inflammation ◽  
Acute Lung Inflammation
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