Early bone response to machined, sandblasting acid etching (SLA) and novel surface-functionalization (SLAffinity) titanium implants: characterization, biomechanical analysis and histological evaluation in pigs

2015 ◽  
Vol 104 (2) ◽  
pp. 397-405 ◽  
Author(s):  
Hsi-Jen Chiang ◽  
Heng-Jui Hsu ◽  
Pei-Wen Peng ◽  
Ching-Zong Wu ◽  
Keng-Liang Ou ◽  
...  
Keyword(s):  
Surface Functionalization ◽  
Titanium Implants ◽  
Biomechanical Analysis ◽  
Histological Evaluation ◽  
Acid Etching ◽  
Bone Response

scholarly journals Histomorphometric Evaluation of Peri-Implant Bone Response to Intravenous Administration of Zoledronate (Zometa®) in an Osteoporotic Rat Model

Materials ◽  
2020 ◽  
Vol 13 (22) ◽  
pp. 5248
Author(s):  
Amani M. Basudan ◽  
Marwa Y. Shaheen ◽  
Abdurahman A. Niazy ◽  
Jeroen J. J. P. van den Beucken ◽  
John A. Jansen ◽  
...  
Keyword(s):  
Femoral Condyle ◽  
Titanium Implants ◽  
Histological Evaluation ◽  
Bone Area ◽  
Treatment Regimens ◽  
Implant Placement ◽  
Bone Response ◽  
Female Wistar Rats ◽  
The Right ◽  
Post Implantation

We evaluated the response to peri-implant bone placed in the femoral condyle of osteoporotic rats, following intravenous zoledronate (ZOL) treatment in three settings: pre-implantation (ZOL-Pre), post-implantation (ZOL-Post), and pre- + post-implantation (ZOL-Pre+Post). Twenty-four female Wistar rats were ovariectomized (OVX). After 12 weeks, the rats received titanium implants in the right femoral condyle. ZOL (0.04 mg/kg, weekly) was administered to six rats 4 weeks pre-implantation and was stopped at implant placement. To another six rats, ZOL was given post-implantation and continued for 6 weeks. Additional six rats received ZOL treatment pre- and post-implantation. Control animals received weekly saline intravenous injections. At 6 weeks post-implantation, samples were retrieved for histological evaluation of the percentage of bone area (%BA) and of the percentage of bone-to-implant contact (%BIC). BA% for ZOL-Pre (29.6% ± 9.0%) and ZOL-Post (27.9% ± 5.6%) rats were significantly increased compared to that of the controls (17.3% ± 3.9%, p < 0.05). In contrast, ZOL-Pre+Post rats (20.4% ± 5.0%) showed similar BA% compared to Saline controls (p = 0.731). BIC% revealed a significant increase for ZOL-Post (65.8% ± 16.9%) and ZOL-Pre+Post (68.3% ± 10.0%) rats compared with that of Saline controls (43.3% ± 9.6%, p < 0.05), while ZOL-Pre rats (55.6% ± 19%) showed a BIC% comparable to that of Saline controls (p = 0.408). Our results suggest that receiving intravenous ZOL treatment before or after implant placement enhances peri-implant bone responses in terms of bone area. However, the effect of different ZOL treatment regimens on BIC% was found to be inconclusive.

Long-Term (9–12 Years) Outcomes of Titanium Implants With an Oxidized Surface: A Retrospective Investigation on 209 Implants

2015 ◽  
Vol 41 (4) ◽  
pp. 437-443 ◽  
Author(s):  
Marco Mozzati ◽  
Giorgia Gallesio ◽  
Massimo Del Fabbro
Keyword(s):  
Survival Rate ◽  
Bone Remodeling ◽  
Titanium Implants ◽  
Pocket Depth ◽  
Long Term Study ◽  
Bone Response ◽  
Single Tooth ◽  
Clinical Records

The aim of this paper is to retrospectively assess the long-term clinical and radiological results in a group of patients treated with Brånemark TiUnite implants supporting mostly single-tooth and partial restorations. The clinical records of 90 consecutive patients (mean age 55.9 years; range 21–82 years), treated with 209 Brånemark System MkIII or MkIV TiUnite implants (72 maxillary/137 mandibular; 26 anterior intercanine/183 posterior sites), were analyzed. Indication types were single tooth (n = 21 implants), partial (n = 180) and full arches (n = 8). A delayed loading protocol was applied in 128 implants, while 81 were immediately loaded. Cumulative survival rate and marginal bone remodeling were evaluated. Marginal bone level was evaluated by an independent radiologist from periapical radiographs taken at implant insertion and at long-term follow up. Plaque, probing pocket depth and peri-implant mucosa conditions were also assessed. The results showed the mean follow-up duration was 11.0 years (range 9.6–12.4 years): 181 implants (90.5%) reached at least 10 years follow-up, 100 implants 11 years, and 17 implants 12 years. Overall, 6 implants failed in 4 patients (5 during the first year and 1 after 2 years) resulting in a 97.1% survival rate after 12 years. Mean bone levels at implant insertion and at the last follow up were −0.90 ± 1.16 mm (mean ± SD; n = 169) and −1.49 ± 0.95 mm (n = 195), respectively. Mean marginal bone remodeling from implant insertion to the last follow-up was −0.60 ± 1.17 mm (n = 168). At the last available follow-up, mean pocket depth was 1.65 ± 0.84 mm. Peri-implant mucosa was normal for the majority (97%) of implants. In conclusion, this retrospective long-term study showed excellent survival rate of TiUnite implants as well as favorable marginal bone response and soft tissue conditions.

scholarly journals Influence of the Thermal Treatment to Address a Better Osseointegration of Ti6Al4V Dental Implants: Histological and Histomorphometrical Study in a Rabbit Model

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Antonio Scarano ◽  
Ezio Crocetta ◽  
Alessandro Quaranta ◽  
Felice Lorusso
Keyword(s):  
Thermal Treatment ◽  
Dental Implants ◽  
Bone Healing ◽  
Rabbit Model ◽  
Titanium Implants ◽  
Control Group ◽  
Left Femur ◽  
Bone Response ◽  
First Choice ◽  
Significant Difference

Background. Pure titanium continues to be the first choice for dental implants and represents the gold standard for their biocompatibility and physical and mechanical characteristics, while the titanium alloy (Ti6Al4V) has good mechanical properties. The surface structure of the titanium oxide layer formation on the surface influences and improves the bone response around dental implants. Purpose. The purpose of this study is to evaluate the influence of a thermal treatment of Ti6Al4V implant surfaces and the bone healing response in a rabbit model. Methods. Altogether sixteen implants with same design were inserted into the distal femoral metaphysis. A screw (13 mm long, 4 mm in diameter) was inserted in an implant bed. Each rabbit received two implants, one in the left femur and one in the right femur. The samples were histologically and histomorphometrically evaluated at 8 weeks. Results. A statistically significant difference (p = 0.000034) was present histologically in the percentages of bone-implant contact (BIC) between the test group (BIC = 69.25±4.49%.) and control group (BIC = 56.25 ± 4.8%) by one-way analysis of variance (ANOVA). Significance was set at p ≤ 0.05. Conclusions. The outcome of the present study indicates a novel approach to improving bone healing around titanium implants.

scholarly journals Surface Functionalization of Orthopedic Titanium Implants with Bone Sialoprotein

PLoS ONE ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. e0153978 ◽  
Author(s):  
Andreas Baranowski ◽  
Anja Klein ◽  
Ulrike Ritz ◽  
Angelika Ackermann ◽  
Joris Anthonissen ◽  
...  
Keyword(s):  
Surface Functionalization ◽  
Bone Sialoprotein ◽  
Titanium Implants

Bone Response to Submerged, Unloaded Implants Inserted in Poor Bone Sites: A Histological and Histomorphometrical Study of 8 Titanium Implants Retrieved From Man

2005 ◽  
Vol 31 (5) ◽  
pp. 225-233 ◽  
Author(s):  
Giovanna Iezzi ◽  
Marco Degidi ◽  
Antonio Scarano ◽  
Vittoria Perrotti ◽  
Adriano Piattelli
Keyword(s):  
Titanium Implants ◽  
Bone Response

scholarly journals Histological evaluation of bone response to bioactive ceramics as graft material in rats

2005 ◽  
Vol 55 (5-6) ◽  
pp. 461-470 ◽  
Author(s):  
Krsljak Elena ◽  
Danilovic Vesna ◽  
Teodorovic Nevenka
Keyword(s):  
Histological Evaluation ◽  
Graft Material ◽  
Bioactive Ceramics ◽  
Bone Response

scholarly journals Experimental Biointegration of a Titanium Implant in Delayed Mandibular Reconstruction

2020 ◽  
Vol 10 (1) ◽  
pp. 6 ◽  
Author(s):  
Alexander Dolgolev ◽  
Igor Reshetov ◽  
Dmitry Svyatoslavov ◽  
Mikhail Sinelnikov ◽  
Konstantin Kudrin ◽  
...  
Keyword(s):  
Bone Matrix ◽  
Titanium Implant ◽  
Titanium Implants ◽  
Mandibular Reconstruction ◽  
Histological Evaluation ◽  
Plastic Plate ◽  
Extensive Resection ◽  
Bone Integration ◽  
Variable Integration

Background: Mandibular reconstruction, after extensive resection of the mandible for the treatment of oral cancer, is a well-known procedure, however, relatively little is known about bone integration into the titanium implant after reconstruction with a temporary plastic implant. The main goal of this experimental study was to study the process of osseous integration into the titanium implant in an in vivo experiment following prior mandibular reconstruction with a temporary plastic implant. Materials and Methods: Four ewes initially underwent a partial one-sided resection of the mandible, with the formation of an approximately 3 × 1 cm defect. All of the subjects received reconstruction with an implantation of a plastic plate (3 cm). The plastic plate was removed and replaced by a titanium implant at 1, 3, 6, and 12 months, accordingly. Both plastic and titanium implants were made via 3D-printing technology and personalized modeling. A total of 6 months after titanium implantation, a histological evaluation of biointegration was performed. Results: All surgeries were uncomplicated. The integration of osseous tissue into the titanium implant was seen in all cases. Histologically, each case showed variable integration of dense fibrotic tissue with fibroblasts and non-mature bone tissue with a definitive layer of bone matrix with many osteoblasts on the periphery. The prior implantation of the plastic plate did not interfere with bone integration into the titanium implant. Conclusion: Preliminary results demonstrated that a temporary plastic implant for mandibular reconstruction does not interfere with the consequent osseous biointegration of a permanent titanium implant. This shows that temporary reconstruction is a safe solution when delayed mandibular reconstruction is required due to disease severity.

Bone Response to New Modified Titanium Surface Implants in Nonhuman Primates (Papio ursinus) and Humans: Histological Evaluation

2008 ◽  
Vol 34 (1) ◽  
pp. 17-24 ◽  
Author(s):  
Carlo Mangano ◽  
Vittoria Perrotti ◽  
Giovanna Iezzi ◽  
Antonio Scarano ◽  
Francesco Mangano ◽  
...  
Keyword(s):  
Nonhuman Primates ◽  
Titanium Surface ◽  
Histological Evaluation ◽  
Papio Ursinus ◽  
Bone Response

Experimental Study of Bone Response to a New Surface Treatment of Endosseous Titanium Implants

2001 ◽  
Vol 10 (2) ◽  
pp. 126-131 ◽  
Author(s):  
Antonio Sanz R ◽  
Alejandro Oyarzún ◽  
Daniel Farias ◽  
Ivan Diaz
Keyword(s):  
Experimental Study ◽  
Surface Treatment ◽  
Titanium Implants ◽  
Bone Response
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