Polyethyleneimine-poly(ethylene glycol)-star-copolymers as efficient and biodegradable vectors for mammalian cell transfection

2013 ◽  
Vol 102 (7) ◽  
pp. 2137-2146 ◽  
Author(s):  
Katharina Ladewig ◽  
Zhi Ping Xu ◽  
Peter Gray ◽  
G. Q. Max Lu
Keyword(s):  
Ethylene Glycol ◽  
Mammalian Cell ◽  
Cell Transfection ◽  
Poly Ethylene Glycol ◽  
Star Copolymers ◽  
Poly Ethylene

scholarly journals Functionalized Poly(ethylene glycol)-Based Bioassay Surface Chemistry That Facilitates Bio-Immobilization and Inhibits Nonspecific Protein, Bacterial, and Mammalian Cell Adhesion

2007 ◽  
Vol 19 (18) ◽  
pp. 4405-4414 ◽  
Author(s):  
Gregory M. Harbers ◽  
Kazunori Emoto ◽  
Charles Greef ◽  
Steven W. Metzger ◽  
Heather N. Woodward ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Ethylene Glycol ◽  
Surface Chemistry ◽  
Mammalian Cell ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Tuning the Density of Poly(ethylene glycol) Chains to Control Mammalian Cell and Bacterial Attachment

Polymers ◽  
2017 ◽  
Vol 9 (12) ◽  
pp. 343 ◽  
Author(s):  
Ahmed Al-Ani ◽  
Hitesh Pingle ◽  
Nicholas P Reynolds ◽  
Peng-Yuan Wang ◽  
Peter Kingshott
Keyword(s):  
Ethylene Glycol ◽  
Mammalian Cell ◽  
Bacterial Attachment ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Synthesis and pyrolysis of ABC type miktoarm star copolymers with polystyrene, poly(lactic acid) and poly(ethylene glycol) arms

2012 ◽  
Vol 48 (10) ◽  
pp. 1755-1767 ◽  
Author(s):  
Suriye Ozlem ◽  
Birol Iskin ◽  
Gorkem Yilmaz ◽  
Manolya Kukut ◽  
Jale Hacaloglu ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Ethylene Glycol ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Star Copolymers ◽  
Miktoarm Star ◽  
Poly Ethylene

RAFT Polymerization of Dual Responsive Hyperbranched-Star Copolymers of Methacrylic Acid and Poly(Ethylene Glycol)

2017 ◽  
Vol 890 ◽  
pp. 78-81 ◽  
Author(s):  
Eduardo C. Atayde Jr. ◽  
Monica M. Berenguel ◽  
Susan D. Arco
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Methacrylic Acid ◽  
Morphological Changes ◽  
Spectroscopic Techniques ◽  
Block Copolymerization ◽  
Poly Ethylene Glycol ◽  
Dual Responsive ◽  
Star Copolymers ◽  
Poly Ethylene

Smart polymers are materials that respond to external stimuli via reversible morphological changes, making them potential systems for drug delivery applications. In this study, dual-responsive star copolymers with a hyperbranched core composed of ethylene glycol dimethacrylate (EGDMA) - methacrylic acid (MAA) and poly(ethylene glycol) methyl ether methacrylate (PEGMA) arms were synthesized via two-step Reversible Addition-fragmentation Chain Transfer (RAFT) block copolymerization. The synthesis involved the formation of the hyperbranched MAA core followed by arm extension with PEGMA. The formation of the hyperbranched core and subsequent copolymerization with PEGMA were verified by FT-IR and 1H-NMR spectroscopic techniques. The distinct EGDMA peak was found at 4.3 ppm while the peak attributed to PEGMA was found at around 3.5 ppm. Furthermore, the synthesized block copolymers were both temperature and pH-responsive with LCST value at 57°C and morphological transition at pH 5.6. The synthesized smart polymer was also biocompatible based on Trypan blue cytotoxicity assay. The inherent dual responsive behavior and biocompatibility of the copolymer render it a good candidate for drug delivery systems.

Synthesis of Amphiphilic Miktoarm Star Copolymers of Poly(n-hexyl isocyanate) and Poly(ethylene glycol) through Reaction with the Active Methylene Group

2008 ◽  
Vol 41 (19) ◽  
pp. 7029-7032 ◽  
Author(s):  
M. Shahinur Rahman ◽  
Mohammad Changez ◽  
Jin-Wook Yoo ◽  
Chi H. Lee ◽  
Shashadhar Samal ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Star Copolymers ◽  
Miktoarm Star ◽  
Poly Ethylene ◽  
Active Methylene ◽  
Methylene Group
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