Synthesis, Self-Assembly, and Drug-Loading Capacity of Well-Defined Cyclodextrin-Centered Drug-Conjugated Amphiphilic A14B7Miktoarm Star Copolymers Based on Poly(ε-caprolactone) and Poly(ethylene glycol)

2010 ◽  
Vol 11 (4) ◽  
pp. 934-943 ◽  
Author(s):  
Peng-Fei Gou ◽  
Wei-Pu Zhu ◽  
Zhi-Quan Shen
Keyword(s):  
Ethylene Glycol ◽  
Self Assembly ◽  
Drug Loading ◽  
Loading Capacity ◽  
Poly Ethylene Glycol ◽  
Star Copolymers ◽  
Poly Ethylene

scholarly journals pH-Sensitive Mixed Micelles Assembled from PDEAEMA-PPEGMA and PCL-PPEGMA for Doxorubicin Delivery: Experimental and DPD Simulations Study

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 170 ◽  
Author(s):  
Chufen Yang ◽  
Wenyao Liu ◽  
Jiayu Xiao ◽  
Cong Yuan ◽  
Yaoxi Chen ◽  
...  
Keyword(s):  
Critical Micelle Concentration ◽  
Ethylene Glycol ◽  
Mixed Micelles ◽  
Drug Loading ◽  
Loading Capacity ◽  
Ph Responsive ◽  
Poly Ethylene Glycol ◽  
Zeta Potentials ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

To decrease critical micelle concentration (CMC), improve stability, and keep high drug-loading capacity, three pH-sensitive mixed micelles applied for anticancer drug controlled delivery were prepared by the mixture of polymers poly (N,N-diethylaminoethyl methacrylate)-b-poly(poly(ethylene glycol) methyl ether methacrylate) (PDEAEMA-PPEGMA) and polycaprolactone-b-poly (poly(ethylene glycol) methyl ether methacrylate) (PCL-PPEGMA), which were synthesized and confirmed by 1H NMR and gel permeation chromatographic (GPC). The critical micelle concentration (CMC) values of the prepared mixed micelles were low, and the micellar sizes and zeta potentials of the blank mixed micelles demonstrated good pH-responsive behavior. Combined experimental techniques with dissipative particle dynamics (DPD) simulation, the particle sizes, zeta potentials, drug loading content (LC), encapsulation efficiency (EE), aggregation morphologies, and doxorubicin (DOX) distribution of the mixed micelles were investigated, and the high DOX-loading capacity of the mixed micelles was found. Both in vitro DOX release profiles and DPD simulations of the DOX dynamics release process exhibited less leakage and good stability in neutral conditions and accelerated drug release behavior with a little initial burst in slightly acidic conditions. Cytotoxicity tests showed that the polymer PDEAEMA-PPEGMA and the blank mixed micelles had good biocompatibility, and DOX-loaded mixed micelles revealed certain cytotoxicity. These results suggest that the drug-loaded mixed micelles that consisted of the two polymers PDEAEMA-PPEGMA and PCL-PPEGMA can be new types of pH-responsive well-controlled release anticancer drug delivery mixed micelles.

'Pseudo-star' Copolymers Formed by a Combination of RAFT Polymerization and Isocyanate-Coupling

2011 ◽  
Vol 64 (8) ◽  
pp. 1047 ◽  
Author(s):  
John Moraes ◽  
Thomas Maschmeyer ◽  
Sébastien Perrier
Keyword(s):  
Ethylene Glycol ◽  
Self Assembly ◽  
Butyl Acrylate ◽  
Raft Polymerization ◽  
Poly Ethylene Glycol ◽  
Reaction Conditions ◽  
One Pot ◽  
Star Copolymers ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

We describe the formation of pseudo-star copolymers via incorporation of an isocyanate-bearing monomer, dimethyl meta-isopropenyl benzyl isocyanate (TMI) into a homopolymer of butyl acrylate (BA) using a one-pot, two-step synthesis. The resultant product maintains the functionality of the isocyanate moiety, which is used to attach poly(ethylene glycol) methyl ether onto the copolymeric chain under benign reaction conditions. The resultant pseudo-star copolymers were isolated and their self-assembly in the presence of water studied.

scholarly journals Tailoring Atomoxetine Release Rate from DLP 3D-Printed Tablets Using Artificial Neural Networks: Influence of Tablet Thickness and Drug Loading

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 111
Author(s):  
Gordana Stanojević ◽  
Djordje Medarević ◽  
Ivana Adamov ◽  
Nikola Pešić ◽  
Jovana Kovačević ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Release Rate ◽  
Drug Loading ◽  
Prolonged Release ◽  
Cylindrical Shape ◽  
Poly Ethylene Glycol ◽  
Scanning Calorimetry ◽  
3D Printed ◽  
Artificial Neural ◽  
Poly Ethylene

Various three-dimensional printing (3DP) technologies have been investigated so far in relation to their potential to produce customizable medicines and medical devices. The aim of this study was to examine the possibility of tailoring drug release rates from immediate to prolonged release by varying the tablet thickness and the drug loading, as well as to develop artificial neural network (ANN) predictive models for atomoxetine (ATH) release rate from DLP 3D-printed tablets. Photoreactive mixtures were comprised of poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) 400 in a constant ratio of 3:1, water, photoinitiator and ATH as a model drug whose content was varied from 5% to 20% (w/w). Designed 3D models of cylindrical shape tablets were of constant diameter, but different thickness. A series of tablets with doses ranging from 2.06 mg to 37.48 mg, exhibiting immediate- and modified-release profiles were successfully fabricated, confirming the potential of this technology in manufacturing dosage forms on demand, with the possibility to adjust the dose and release behavior by varying drug loading and dimensions of tablets. DSC (differential scanning calorimetry), XRPD (X-ray powder diffraction) and microscopic analysis showed that ATH remained in a crystalline form in tablets, while FTIR spectroscopy confirmed that no interactions occurred between ATH and polymers.

Synthesis and self-assembly behaviour of poly(Nα-Boc-l-tryptophan)-block-poly(ethylene glycol)-block-poly(Nα-Boc-l-tryptophan)

RSC Advances ◽  
2016 ◽  
Vol 6 (29) ◽  
pp. 24142-24153
Author(s):  
Andreea S. Voda ◽  
Kevin Magniez ◽  
Nisa V. Salim ◽  
Cynthia Wong ◽  
Qipeng Guo
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Potential Drug ◽  
Poly Ethylene Glycol ◽  
Drug Delivery Applications ◽  
Poly Ethylene ◽  
First Time

We report for the first time the use of Nα-Boc-l-tryptophan for the synthesis of amphiphilic BAB triblock copolymers for potential drug delivery applications.

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