Suspension polymerization of 2-hydroxyethyl methacrylate in the presence of polymeric diluents: A novel route to spherical highly porous beads for biomedical applications

1990 ◽  
Vol 24 (7) ◽  
pp. 913-927 ◽  
Author(s):  
J. Jayakrishnan ◽  
B. Chithambara Thanoo
Keyword(s):  
Biomedical Applications ◽  
Suspension Polymerization ◽  
Hydroxyethyl Methacrylate ◽  
Porous Beads ◽  
Highly Porous

scholarly journals Amphipathic Substrates Based on Crosslinker-Free Poly(ε-Caprolactone):Poly(2-Hydroxyethyl Methacrylate) Semi-Interpenetrated Networks Promote Serum Protein Adsorption

Polymers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1256
Author(s):  
Guillermo Vilariño-Feltrer ◽  
Alfredo Salgado-Gallegos ◽  
Joan de-la-Concepción-Ausina ◽  
José Carlos Rodríguez-Hernández ◽  
Mohsen Shahrousvand ◽  
...  
Keyword(s):  
Serum Protein ◽  
Biomedical Applications ◽  
Simple Procedure ◽  
Solution Polymerization ◽  
Hydroxyethyl Methacrylate ◽  
Polymer Substrates ◽  
Step Procedure ◽  
Physically Crosslinked ◽  
Hydroxyl Hydrogen ◽  
Polymer Fraction

A simple procedure has been developed to synthesize uncrosslinked soluble poly(hydroxyethyl methacrylate) (PHEMA) gels, ready for use in a subsequent fabrication stage. The presence of 75 wt % methanol (MetOH) or dimethylformamide (DMF) impedes lateral hydroxyl–hydroxyl hydrogen bonds between PHEMA macromers to form during their solution polymerization at 60 °C, up to 24 h. These gels remain soluble when properly stored in closed containers under cold conditions and, when needed, yield by solvent evaporation spontaneous physically-crosslinked PHEMA adapted to the mould used. Moreover, this two-step procedure allows obtaining multicomponent systems where a stable and water-affine PHEMA network would be of interest. In particular, amphiphilic polycaprolactone (PCL):PHEMA semi-interpenetrated (sIPN) substrates have been developed, from quaternary metastable solutions in chloroform (CHCl3):MetOH 3:1 wt. and PCL ranging from 50 to 90 wt % in the polymer fraction (thus determining the composition of the solution). The coexistence of these countered molecules, uniformly distributed at the nanoscale, has proven to enhance the number and interactions of serum protein adsorbed from the acellular medium as compared to the homopolymers, the sIPN containing 80 wt % PCL showing an outstanding development. In accordance to the quaternary diagram presented, this protocol can be adapted for the development of polymer substrates, coatings or scaffolds for biomedical applications, not relying upon phase separation, such as the electrospun mats here proposed herein (12 wt % polymer solutions were used for this purpose, with PCL ranging from 50% to 100% in the polymer fraction).

Temperature-responsive hydrogels containing new LCST methacrylate macromonomers

e-Polymers ◽  
2007 ◽  
Vol 7 (1) ◽  
Author(s):  
Anna Korytkowska-Wałach ◽  
Anna Porwoł ◽  
Mirosław Gibas
Keyword(s):  
Phase Transition ◽  
Biomedical Applications ◽  
Tetraethylene Glycol ◽  
Temperature Sensitive ◽  
Hydroxyethyl Methacrylate ◽  
Temperature Responsive ◽  
Michael Type Addition ◽  
Responsive Hydrogels ◽  
Ether Ester ◽  
Gel Transition

AbstractA series of hydrogels were synthesized: homopolymers of new temperature-sensitive methacrylate macromonomers of ether-ester structure, derived from monomethacrylate of tetraethylene glycol via Michael-type addition - oligo(TTEGMMA), and copolymers of oligo(TTEGMMA) with N-isopropylacrylamide (NIPAAm) or 2-hydroxyethyl methacrylate (HEMA). Hydrogels based on oligo(TTEGMMA) demonstrate broad volume phase transition. Combination of oligo(TTEGMMA) with NIPAAm or HEMA yielded hydrogels having narrower phase transition and lower gel transition temperature (LGTT) up to 43 °C at the most, which is in the range of interest for most biomedical applications.

Reactive polymeric carriers obtained by suspension polymerization of hydroxyethyl methacrylate sulphonates

1983 ◽  
Vol 48 (11) ◽  
pp. 3065-3070 ◽  
Author(s):  
Milan J. Beneš ◽  
Jan Peška
Keyword(s):  
Suspension Polymerization ◽  
Hydroxyethyl Methacrylate ◽  
Polymeric Sorbents ◽  
Polymeric Carriers ◽  
Single Precursor

Reaction of monomeric 2-hydroxyethyl methacrylate with sulphochlorides, such as e.g. toluenesulphonyl chloride, gives rise to asymmetrical ethylene esters which can be polymerized to beads possessing alkylating properties. In this procedure, a single precursor can be used to prepare a large variety of polymeric sorbents, catalysts, and the like.

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