Reactive polymeric carriers obtained by suspension polymerization of hydroxyethyl methacrylate sulphonates

1983 ◽  
Vol 48 (11) ◽  
pp. 3065-3070 ◽  
Author(s):  
Milan J. Beneš ◽  
Jan Peška
Keyword(s):  
Suspension Polymerization ◽  
Hydroxyethyl Methacrylate ◽  
Polymeric Sorbents ◽  
Polymeric Carriers ◽  
Single Precursor

Reaction of monomeric 2-hydroxyethyl methacrylate with sulphochlorides, such as e.g. toluenesulphonyl chloride, gives rise to asymmetrical ethylene esters which can be polymerized to beads possessing alkylating properties. In this procedure, a single precursor can be used to prepare a large variety of polymeric sorbents, catalysts, and the like.

New sulfur-containing polymeric sorbents based on 2,2′-thiobisethanol dimethacrylate

2019 ◽  
Vol 91 (3) ◽  
pp. 409-420 ◽  
Author(s):  
Sylwia Ronka
Keyword(s):  
Metal Ions ◽  
Methylene Chloride ◽  
Suspension Polymerization ◽  
Polymer Chains ◽  
Synthesis Conditions ◽  
Polymeric Sorbents ◽  
Sorption Ability ◽  
Donor Acceptor ◽  
Precious Metal Ions ◽  
Selection Of

Abstract The first step in obtaining of a specific polymer sorbent containing sulfur atoms was the synthesis of a functional monomer – 2,2′-thiobisethanol dimethacrylate (TEDM). Synthesis consists of the reaction of 2,2′-thiobisethanol with methacryloyl chloride in the presence of triethylamine in methylene chloride. The new poly(dimethacrylate)s materials containing sulfur atoms were synthesized in radical suspension polymerization. Homopolymerization of 2,2′-thiobisethanol dimethacrylate and its copolymerization with ethylene glycol dimethacrylate or pentaerythritol tetraacrylate were carried out. The selection of synthesis conditions determines the parameters of the polymer structure and its properties. The presence of sulfur atoms in polymer chains resulted in specific donor-acceptor interactions, which can intensify sorption ability towards metal ions belonging to the group of soft acids. Therefore, the sorption properties of the obtained materials have been determined based on the recovery of precious metal ions, such as gold(III) and silver(I).

A New Embolization Agent: Embolization of the Kidneys with Ethylene Glycol Dimethacrylate-Hydroxyethyl Methacrylate Copolymer Microbeads

2001 ◽  
Vol 16 (5) ◽  
pp. 367-377 ◽  
Author(s):  
Cumhur çeken ◽  
Hakan Ayhan ◽  
Erhan PişKin ◽  
Sadik Bilgin
Keyword(s):  
Ethylene Glycol ◽  
Contrast Agent ◽  
Suspension Polymerization ◽  
Ethylene Glycol Dimethacrylate ◽  
Second Step ◽  
Hydroxyethyl Methacrylate ◽  
Swelling Ratio ◽  
Glycol Dimethacrylate ◽  
Pathological Changes ◽  
Methacrylate Copolymer

Ethylene glycol dimethacrylate (EGDMA)-hydroxyethyl methacrylate (HEMA) copolymer microbeads (125-150,jm in diameter) were produced by suspension polymerization. The percent of HEMA incorporated and the swelling ratio of the non-porous microbeads produced were 12% and 22.7%, respectively. Microbeads, sterilized with ethylene oxide, were used in the embolization of the kidneys of three adult mongrel dogs by angiography. The effectiveness of the embolization was examined by angiographs after each step. In the first step of the embolization, the microbeads reached the pre-capillaries and blood flow was successfully blocked, which was confirmed by accumulation of the contrast agent within the kidneys. In angiograms after another injection, as the second step, again there were neither contrast agent movement toward the kidneys nor distribution through the paranchyme. The embolized kidneys were subjected to histopathologic examinations where pathological changes were observed.

Preparation of the Polylactide Copolymer by Surface Grafting with Microspheres

2010 ◽  
Vol 428-429 ◽  
pp. 90-93
Author(s):  
Yu Shun Jin ◽  
Fei Xiao ◽  
Wen Li Guo ◽  
Shu Xin Li
Keyword(s):  
Thermogravimetric Analysis ◽  
Polylactic Acid ◽  
Suspension Polymerization ◽  
Random Copolymer ◽  
Surface Grafting ◽  
Hydroxyethyl Methacrylate ◽  
Structures And Properties ◽  
New Type ◽  
Ft Ir ◽  
Copolymer Poly

The microsphere copolymer [poly(St-co-HEMA)] of monodispersed styrene and 2-hydroxyethyl methacrylate(HEMA) was synthesized by suspension polymerization. New type of hydrophobic microsphere was synthesized by surface grafting polylactic acid using the hydroxyl-terminated of poly (St-co-HEMA) as initiator. The microspheres’ structures and properties were characterized by FT-IR, SEM and thermogravimetric analysis. The results have demonstrated that the copolymer [poly(St-co-HEMA)] is a random copolymer. The volume of the polylactide which was grafted with the microspheres can be controlled by changing the amount of microspheres and hydroxyl in microspheres.

Synthesis and Photoproperties of a Substituted Zinc(II) Phthalocyanine-N-(2-hydroxypropyl)methacrylamide Copolymer Conjugate

1993 ◽  
Vol 58 (10) ◽  
pp. 2321-2336 ◽  
Author(s):  
Zhong-wei Gu ◽  
John D. Spikes ◽  
Pavla Kopečková ◽  
Jindřich Kopeček
Keyword(s):  
Organic Solvents ◽  
Water Soluble ◽  
Lower Probability ◽  
Hpma Copolymer ◽  
Polymeric Derivative ◽  
Oxygen Generation ◽  
Hpma Copolymers ◽  
Hydroxypropyl Methacrylamide ◽  
Polymeric Carriers ◽  
Thiol Proteinases

In cancer photodynamic therapy (PDT), improved efficiency of photosensitizer delivery to tumors may be obtained by binding them to targetable water soluble polymeric carriers. However, attachment of photosensitizers to Macromolecular carriers may alter their spectral and photosensitizing properties. In this study, a new monosubstituted phthalocyanine derivative, N-glycyl zinc(II) 4,9,16,23-tetraaminophthalocyanine (G-TAPC-Zn) was synthesized by the reaction of zinc(II) 4,9,16,23-tetraaminophthalocyanine (TAPC-Zn) with N-tert-butoxycarbonyl-glycine N'-hydroxybenzotriazole ester followed by deprotection of the tert-butoxycarbonyl (BOC) group. G-TAPC-Zn contains an aliphatic amino group suitable for attachment to water soluble polymeric carriers. By aminolysis of a polymeric precursor, an N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer containing oligopeptide (GFLG) side-chains terminated in p-nitrophenyl ester groups, with G-TAPC-Zn a polymeric derivative of the latter (P-GFLGG-TAPC-Zn) was synthesized. Spectral data indicated that in aqueous solutions P-GFLGG-TAPC-Zn formed aggregates. The degree of aggregation decreased with increasing concentration of detergents or organic solvents in buffer solutions. Consequently, the release of the drug from carrier catalyzed by thiol proteinases, papain or cathepsin B, took place only in the presence of detergents or organic solvents, i.e., under conditions with a lower probability of aggregate formation. Binding of G-TAPC-Zn to HPMA copolymers decreased the quantum yield of singlet oxygen generation from 0.24 to 0.063 and significantly increased its resistance to photobleaching.

Sign in / Sign up

Export Citation Format

Share Document