Lack of miR‐1246 in small extracellular vesicle blunts tumorigenesis of laryngeal carcinoma cells by regulating Cyclin G2

IUBMB Life ◽  
2020 ◽  
Vol 72 (7) ◽  
pp. 1491-1503 ◽  
Author(s):  
Qiang Huang ◽  
Chi‐Yao Hsueh ◽  
Yang Guo ◽  
Xiu‐Fa Wu ◽  
Jiao‐Yu Li ◽  
...  
Keyword(s):  
Laryngeal Carcinoma ◽  
Extracellular Vesicle ◽  
Carcinoma Cells ◽  
Cyclin G2

scholarly journals Genotoxic Effects of Green Tea Extract on Human Laryngeal Carcinoma Cells In Vitro

2011 ◽  
Vol 62 (2) ◽  
pp. 139-146 ◽  
Author(s):  
Ksenija Durgo ◽  
Sandra Kostić ◽  
Katarina Gradiški ◽  
Draženka Komes ◽  
Maja Osmak ◽  
...  
Keyword(s):  
Cell Line ◽  
Green Tea ◽  
Laryngeal Carcinoma ◽  
Resistant Cell ◽  
Resistant Cell Line ◽  
Green Tea Extract ◽  
Carcinoma Cells ◽  
Tea Extract ◽  
Human Laryngeal Carcinoma

Genotoxic Effects of Green Tea Extract on Human Laryngeal Carcinoma Cells In VitroGreen tea (Camellia sinensis) contains several bioactive compounds which protect the cell and prevent tumour development. Phytochemicals in green tea extract (mostly flavonoids) scavenge free radicals, but also induce pro-oxidative reactions in the cell. In this study, we evaluated the potential cytotoxic and prooxidative effects of green tea extract and its two main flavonoid constituents epigallocatechin gallate (EGCG) and epicatechin gallate (ECG) on human laryngeal carcinoma cell line (HEp2) and its cross-resistant cell line CK2. The aim was to see if the extract and its two flavonoids could increase the sensitivity of the cisplatin-resistant cell line CK2 in comparison to the parental cell line. The results show that EGCG and green tea extract increased the DNA damage in the CK2 cell line during short exposure. The cytotoxicity of EGCG and ECG increased with the time of incubation. Green tea extract induced lipid peroxidation in the CK2 cell line. The pro-oxidant effect of green tea was determined at concentrations higher than those found in traditionally prepared green tea infusions.

FTIR spectroscopy reveals lipid droplets in drug resistant laryngeal carcinoma cells through detection of increased ester vibrational bands intensity

The Analyst ◽  
2014 ◽  
Vol 139 (13) ◽  
pp. 3407-3415 ◽  
Author(s):  
Sanjica Rak ◽  
Tihana De Zan ◽  
Jasminka Stefulj ◽  
Marin Kosović ◽  
Ozren Gamulin ◽  
...  
Keyword(s):  
Cholesteryl Ester ◽  
Ftir Spectroscopy ◽  
Laryngeal Carcinoma ◽  
Lipid Droplets ◽  
Multidrug Resistant ◽  
Carcinoma Cells ◽  
Drug Resistant ◽  
Lipid Droplet Formation ◽  
Cholesteryl Ester Content ◽  
Vibrational Bands

Specific differences in FTIR spectra of HEp-2 cells and their multidrug resistant 7T subline were observed and the increased cholesteryl ester content and enhanced lipid droplet formation in 7T cells were verified.

scholarly journals CIP2A, an oncoprotein, is associated with cell proliferation, invasion and migration in laryngeal carcinoma cells

2017 ◽  
Vol 38 (2) ◽  
pp. 1005-1012 ◽  
Author(s):  
Xu-Dong Chen ◽  
Shi-Xiong Tang ◽  
Jian-Hua Zhang ◽  
Li-Tao Zhang ◽  
Yao-Wen Wang
Keyword(s):  
Cell Proliferation ◽  
Laryngeal Carcinoma ◽  
Carcinoma Cells ◽  
Invasion And Migration ◽  
And Migration
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