Characterization of regional differences in cerebral vascular response to breath holding using BOLD fMRI

2020 ◽  
Author(s):  
Chun‐Ming Chen ◽  
Hui‐Chieh Yang ◽  
Hsin‐Hua Hsieh ◽  
Tsai‐Ying Liao ◽  
Yen‐Chih Huang ◽  
...  
Keyword(s):  
Regional Differences ◽  
Breath Holding ◽  
Vascular Response ◽  
Bold Fmri ◽  
Cerebral Vascular

scholarly journals Regional Differences in Cerebral Vascular Response to Paco2 Changes in Humans Measured by Positron Emission Tomography

2000 ◽  
Vol 20 (8) ◽  
pp. 1264-1270 ◽  
Author(s):  
Hiroshi Ito ◽  
Ikuo Yokoyama ◽  
Hidehiro Iida ◽  
Toshibumi Kinoshita ◽  
Jun Hatazawa ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Regional Differences ◽  
Emission Tomography ◽  
Brain Anatomy ◽  
Vascular Response ◽  
Large Capacity ◽  
Perfusion Reserve ◽  
Positron Emission ◽  
Cerebral Vasodilation ◽  
Cerebral Vascular

Hypercapnia and hypocapnia produce cerebral vasodilation and vasoconstriction, respectively. However, regional differences in the vascular response to changes in Paco2 in the human brain are not pronounced. In the current study, these regional differences were evaluated. In each of the 11 healthy subjects, cerebral blood flow (CBF) was measured using 15O-water and positron emission tomography at rest and during hypercapnia and hypocapnia. All CBF images were globally normalized for CBF and transformed into the standard brain anatomy. t values between rest and hypercapnia or hypocapnia conditions were calculated on a pixel-by-pixel basis. In the pons, cerebellum, thalamus, and putamen, significant relative hyperperfusion during hypercapnia was observed, indicating a large capacity for vasodilatation. In the pons and putamen, a significant relative hypoperfusion during hypocapnia, that is, a large capacity for vasoconstriction, was also observed, indicating marked vascular responsiveness. In the temporal, temporo-occipital, and occipital cortices, significant relative hypoperfusion during hypercapnia and significant relative hypoperfusion during hypocapnia were observed, indicating that cerebral vascular tone at rest might incline toward vasodilatation. Such regional heterogeneity of the cerebral vascular response should be considered in the assessment of cerebral perfusion reserve by hypercapnia and in the correction of CBF measurements for variations in subjects' resting Paco2.

scholarly journals CHARACTERIZATION OF REGIONAL DIFFERENCES IN PATHOLOGICAL LV REMODELING: INSIGHTS FROM 3D ECHOCARDIOGRAPHIC ANALYSIS

2015 ◽  
Vol 65 (10) ◽  
pp. A1327
Author(s):  
Yong Hyun Park ◽  
Mark Handschumacher ◽  
Xin Zeng ◽  
Timothy Tan ◽  
Romain Capoulade ◽  
...  
Keyword(s):  
Regional Differences ◽  
Lv Remodeling

scholarly journals Calibration of BOLD fMRI using breath holding reduces group variance during a cognitive task

2006 ◽  
Vol 28 (1) ◽  
pp. 59-68 ◽  
Author(s):  
Moriah E. Thomason ◽  
Lara C. Foland ◽  
Gary H. Glover
Keyword(s):  
Cognitive Task ◽  
Breath Holding ◽  
Bold Fmri

Effect of Nitric Oxide Synthase Inhibition on the Cerebral Vascular Response to Hypercapnia in Primates

Stroke ◽  
1995 ◽  
Vol 26 (4) ◽  
pp. 682-687 ◽  
Author(s):  
Robert W. McPherson ◽  
Jeffrey R. Kirsch ◽  
Ramsis F. Ghaly ◽  
Richard J. Traystman
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Vascular Response ◽  
Oxide Synthase ◽  
Cerebral Vascular

scholarly journals Vascular Reactivity Maps in Patients with Gliomas Using Breath-Holding BOLD fMRI

2015 ◽  
Vol 26 (2) ◽  
pp. 232-239 ◽  
Author(s):  
Amir Iranmahboob ◽  
Kyung K. Peck ◽  
Nicole P. Brennan ◽  
Sasan Karimi ◽  
Ryan Fisicaro ◽  
...  
Keyword(s):  
Vascular Reactivity ◽  
Breath Holding ◽  
Bold Fmri

Mapping of the cerebral vascular response to hypoxia and hypercapnia using quantitative perfusion MRI at 3 T

2007 ◽  
Vol 21 (5) ◽  
pp. 464-472 ◽  
Author(s):  
Ulrike Nöth ◽  
Futoshi Kotajima ◽  
Ralf Deichmann ◽  
Robert Turner ◽  
Douglas R. Corfield
Keyword(s):  
Perfusion Mri ◽  
Vascular Response ◽  
Quantitative Perfusion ◽  
Cerebral Vascular

Effect of acetylcholine on cerebral circulation

1976 ◽  
Vol 45 (4) ◽  
pp. 423-431 ◽  
Author(s):  
Masayuki Matsuda ◽  
John Stirling Meyer ◽  
Vinod D. Deshmukh ◽  
Yukio Tagashira
Keyword(s):  
Intravenous Infusion ◽  
Cerebral Metabolism ◽  
Vascular Response ◽  
Venous Outflow ◽  
Content Type ◽  
Cerebral Metabolic Rate ◽  
Arousal Effect ◽  
Cerebral Vascular Resistance ◽  
Fine Print ◽  
Cerebral Vascular

✓ Effects of intravertebral, intracarotid, and intravenous infusion of acetylcholine on cerebral blood flow (CBF) and metabolism were studied in 17 baboons anesthetized with pentobarbital. We measured CBF by the bilateral jugular venous outflow technique using two electromagnetic flowmeters. Effect of acetylcholine infusion on cerebral vascular response to hypercapnia was also assessed. Intravertebral infusion of acetylcholine (0.01 mg/kg/min) increased CBF by 27% and cerebral metabolic rate for oxygen by 19% and decreased cerebral vascular resistance by 25%. On intracarotid injection of acetylcholine, only an 8% increase in CBF was observed, and intravenous infusion produced no change in the parameters observed. Acetylcholine administered by any of the three routes did not enhance the CBF response to hypercapnia. Increase in CBF on intravertebral administration of acetylcholine is associated with an arousal effect and an increase in cerebral metabolism.

CEREBRAL VASCULAR RESPONSE TO HYPEROXIA IN HEAD INJURED PATIENTS

1999 ◽  
Vol 27 (Supplement) ◽  
pp. A60
Author(s):  
Claudia S Robertson ◽  
Alex B Valadka ◽  
Ari G Chacko ◽  
Yasafumi Mizutani
Keyword(s):  
Vascular Response ◽  
Head Injured ◽  
Injured Patients ◽  
Cerebral Vascular

scholarly journals Cerebral vascular response to moderate blood loss: modification by hypertension.

Stroke ◽  
1983 ◽  
Vol 14 (5) ◽  
pp. 765-768 ◽  
Author(s):  
F P Holladay ◽  
J R Bean ◽  
B Young ◽  
E P Todd ◽  
M W Roy
Keyword(s):  
Blood Loss ◽  
Vascular Response ◽  
Cerebral Vascular
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