Mapping of the cerebral vascular response to hypoxia and hypercapnia using quantitative perfusion MRI at 3 T

2007 ◽  
Vol 21 (5) ◽  
pp. 464-472 ◽  
Author(s):  
Ulrike Nöth ◽  
Futoshi Kotajima ◽  
Ralf Deichmann ◽  
Robert Turner ◽  
Douglas R. Corfield
Keyword(s):  
Perfusion Mri ◽  
Vascular Response ◽  
Quantitative Perfusion ◽  
Cerebral Vascular

scholarly journals Cerebral vascular response to hypercapnia: Determination with perfusion MRI at 1.5 and 3.0 Tesla using a pulsed arterial spin labeling technique

2006 ◽  
Vol 24 (6) ◽  
pp. 1229-1235 ◽  
Author(s):  
Ulrike Nöth ◽  
Guy E. Meadows ◽  
Futoshi Kotajima ◽  
Ralf Deichmann ◽  
Douglas R. Corfield ◽  
...  
Keyword(s):  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Perfusion Mri ◽  
Vascular Response ◽  
3.0 Tesla ◽  
Cerebral Vascular

Abstract 1681: Evaluation of Quantitative Myocardial Perfusion MRI and TIMI myocardial blush grade (Blush score)

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Hiroshi Nakajima ◽  
Shinya Okamoto ◽  
Hajime Sakuma ◽  
Tairo Kurita ◽  
Motonori Nagata ◽  
...  
Keyword(s):  
Coronary Angiography ◽  
Myocardial Perfusion ◽  
Area Under The Curve ◽  
Primary Angioplasty ◽  
Perfusion Mri ◽  
St Segment Elevation ◽  
Quantitative Perfusion ◽  
Timi Grade ◽  
Significant Difference ◽  
Myocardial Blush Grade

Background: The TIMI myocardial blush grade (MBG) has been shown to be a strong angiographic predictor of mortality in patients with TIMI 3 flow after primary angioplasty. This study was conducted to evaluate the relationship between regional myocardial perfusion quantified by cardiac magnetic resonance and angiographic reperfusion score defined by MBG. Methods: We studied 29 consecutive patients (25 men, age 63±13 years) with ST-segment elevation acute myocardial infarction (LAD lesion: 12, RCA lesion: 16, LCx lesion: 2) who underwent primary angioplasty within 6 hours from the onset and showed TIMI grade 3. MBG was determined on angiography at the end of angioplasty. All patients underwent rest myocardial perfusion MRI during initial hospitalization, and regional MBF (ml/min/g) was quantified by using a Patlak plot method. Myocardial perfusion (MP) ratio was calculated from quantitative perfusion MRI, as MBF in infarction area/MBF in normal area. The optimal cut-off value of MP ratio that can predict MBG 3 on coronary angiography was determined by using a receiver-operating characteristic (ROC) analysis. Results: In 29 patients with TIMI 3 flow after angioplasty, 4 patients had MBG 0–1, 7 had MBG 2 and 18 had MBG 3. The MP ratio in MBG 3 group calculated from quantitative perfusion MRI was significantly higher than the MP ratios in MBG 0 –1 group and MBG 2 group (0.96±0.18 vs. 0.48±0.25, P<0.001; 0.96±0.18 vs. 0.66±0.19, P=0.003, respectively). There was no significant difference between the MP ratios in MBG 0 –1 group and MBG 2 group. The ROC curve revealed that MP ratio of 0.74 is an optimal threshold to distinguish MBG 3 from MBG 0 –2, with a high area under the curve of 0.90. Conclusions: The result of this study demonstrates that MP ratio quantified from rest perfusion MRI correlated well with MBG on coronary angiography.

Effect of Nitric Oxide Synthase Inhibition on the Cerebral Vascular Response to Hypercapnia in Primates

Stroke ◽  
1995 ◽  
Vol 26 (4) ◽  
pp. 682-687 ◽  
Author(s):  
Robert W. McPherson ◽  
Jeffrey R. Kirsch ◽  
Ramsis F. Ghaly ◽  
Richard J. Traystman
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Vascular Response ◽  
Oxide Synthase ◽  
Cerebral Vascular

scholarly journals Early detection of antiangiogenic treatment responses in a mouse xenograft tumor model using quantitative perfusion MRI

2014 ◽  
Vol 3 (1) ◽  
pp. 47-60 ◽  
Author(s):  
Reshmi Rajendran ◽  
Wei Huang ◽  
Annie Mei Yee Tang ◽  
Jie Ming Liang ◽  
Stephanie Choo ◽  
...  
Keyword(s):  
Early Detection ◽  
Tumor Model ◽  
Perfusion Mri ◽  
Xenograft Tumor ◽  
Antiangiogenic Treatment ◽  
Mouse Xenograft ◽  
Quantitative Perfusion ◽  
Xenograft Tumor Model ◽  
Treatment Responses

Effect of acetylcholine on cerebral circulation

1976 ◽  
Vol 45 (4) ◽  
pp. 423-431 ◽  
Author(s):  
Masayuki Matsuda ◽  
John Stirling Meyer ◽  
Vinod D. Deshmukh ◽  
Yukio Tagashira
Keyword(s):  
Intravenous Infusion ◽  
Cerebral Metabolism ◽  
Vascular Response ◽  
Venous Outflow ◽  
Content Type ◽  
Cerebral Metabolic Rate ◽  
Arousal Effect ◽  
Cerebral Vascular Resistance ◽  
Fine Print ◽  
Cerebral Vascular

✓ Effects of intravertebral, intracarotid, and intravenous infusion of acetylcholine on cerebral blood flow (CBF) and metabolism were studied in 17 baboons anesthetized with pentobarbital. We measured CBF by the bilateral jugular venous outflow technique using two electromagnetic flowmeters. Effect of acetylcholine infusion on cerebral vascular response to hypercapnia was also assessed. Intravertebral infusion of acetylcholine (0.01 mg/kg/min) increased CBF by 27% and cerebral metabolic rate for oxygen by 19% and decreased cerebral vascular resistance by 25%. On intracarotid injection of acetylcholine, only an 8% increase in CBF was observed, and intravenous infusion produced no change in the parameters observed. Acetylcholine administered by any of the three routes did not enhance the CBF response to hypercapnia. Increase in CBF on intravertebral administration of acetylcholine is associated with an arousal effect and an increase in cerebral metabolism.

CEREBRAL VASCULAR RESPONSE TO HYPEROXIA IN HEAD INJURED PATIENTS

1999 ◽  
Vol 27 (Supplement) ◽  
pp. A60
Author(s):  
Claudia S Robertson ◽  
Alex B Valadka ◽  
Ari G Chacko ◽  
Yasafumi Mizutani
Keyword(s):  
Vascular Response ◽  
Head Injured ◽  
Injured Patients ◽  
Cerebral Vascular

Characterization of regional differences in cerebral vascular response to breath holding using BOLD fMRI

2020 ◽  
Author(s):  
Chun‐Ming Chen ◽  
Hui‐Chieh Yang ◽  
Hsin‐Hua Hsieh ◽  
Tsai‐Ying Liao ◽  
Yen‐Chih Huang ◽  
...  
Keyword(s):  
Regional Differences ◽  
Breath Holding ◽  
Vascular Response ◽  
Bold Fmri ◽  
Cerebral Vascular

scholarly journals Cerebral vascular response to moderate blood loss: modification by hypertension.

Stroke ◽  
1983 ◽  
Vol 14 (5) ◽  
pp. 765-768 ◽  
Author(s):  
F P Holladay ◽  
J R Bean ◽  
B Young ◽  
E P Todd ◽  
M W Roy
Keyword(s):  
Blood Loss ◽  
Vascular Response ◽  
Cerebral Vascular
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