Differences in expression patterns of the tight junction proteins,claudin 1, 3, 4 and 5, in human ovarian surface epithelium as compared to epithelia in inclusion cysts and epithelial ovarian tumours

2005 ◽  
Vol 118 (8) ◽  
pp. 1884-1891 ◽  
Author(s):  
Yihong Zhu ◽  
Mats Brännström ◽  
P.-O. Janson ◽  
Karin Sundfeldt
2003 ◽  
pp. 223-226 ◽  
Author(s):  
Nikolas K. Haass ◽  
Pia Houdek ◽  
Ewa Wladykowski ◽  
Ingrid Moll ◽  
Johanna M. Brandner

2021 ◽  
Vol 11 (10) ◽  
pp. 4710
Author(s):  
Coralia Cotoraci ◽  
Alciona Sasu ◽  
Eftimie Miutescu ◽  
Dana Iovanescu ◽  
Sami Gharbia ◽  
...  

Chemotherapy and radiation are often accompanied by complications such as intestinal mucositis. The aim of this study was to assess by immunohistochemical assay the consequences of epirubicin-based therapy applied to onco-hematological patients, on the mucosal cells that undergo apoptosis and on the tight junction proteins, immediately before and after a short time of chemotherapy administration. We assessed the protein expression and distribution of the pro-apoptotic Bax, anti-apoptotic Bcl-2 and effector Caspase-3 as key proteins in apoptosis pathways and the changes in immunopositivity of Claudin-1 and ZO-1 tight junction proteins. Results show that the Bcl-2 family is involved in intestinal damage via Caspase-3 dependent apoptosis of epithelial cells. Additionally, the intestinal mucositis activates other injurious pathways through a dramatic drop in Claudin-1 and ZO-1 expressions, contributing for a while to a structural and functional integrity disruption of the intestinal epithelium.


2007 ◽  
Vol 127 (4) ◽  
pp. 457-462 ◽  
Author(s):  
Naoyuki Sakai ◽  
Hideki Chiba ◽  
Hiroki Fujita ◽  
Yushi Akashi ◽  
Makoto Osanai ◽  
...  

2018 ◽  
Vol 233 (2) ◽  
pp. 167-176 ◽  
Author(s):  
Xue-Ming Zhang ◽  
Yan Huang ◽  
Kuo Zhang ◽  
Ling-Han Qu ◽  
Xin Cong ◽  
...  

2005 ◽  
Vol 43 (05) ◽  
Author(s):  
Cs Páska ◽  
E Orbán ◽  
A Kiss ◽  
Zs Schaff ◽  
A Szijjártó ◽  
...  

2017 ◽  
Vol 95 (3) ◽  
pp. 1313 ◽  
Author(s):  
L. Zhang ◽  
L. F. Schütz ◽  
C. L. Robinson ◽  
M. L. Totty ◽  
L. J. Spicer

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